Informatics Core

转化性研究，如黑色素瘤和皮肤计划(MSCP)孢子中提出的，有一系列需求，这些需求受益于软件解决方案，包括临床信息注释、数据仓库和疾病建模/分析工具。信息学核心(核心D)将以下列方式为MSCP孢子的项目和核心提供服务： 项目1.信息学核心将负责研究信息服务(RIS)的数据提取和临床注释，以支持E1609患者队列，并确保将这些数据整合到研究数据仓库(RDW)中，供生物统计核心(核心C)使用。 项目2.信息学核心将使用我们的临床表型工具，帮助研究与项目2队列中的治疗相关的毒性的管理。该项目还需要使用Core D的临床试验管理应用程序(CTMA)和RIS提供的我们的临床注释专业知识。值得注意的是，CTMA将服务于所有项目的临床研究管理系统(CRMS)需求。 项目3.核心D将提供对项目3的临床注释数据的访问，并将这些数据提供给孢子团队以及生物统计核心。这项研究将从我们的电子病历(EMR)系统中收集电子数据，并使用我们的队列发现工具(GIGNAL)进行分析。这个项目产生的研究数据也将被纳入我们的RDW。 项目4.CORE D将(通过GIGNAL)开发算法，以识别可能符合该项目纳入条件的转移性黑色素瘤患者，并协调从RIS收集临床注释。 核心A(行政)。信息学核心将确保必要的试验数据被记录、存储、备份，并可供项目绩效指标审查和向内部和外部咨询委员会以及国家癌症研究所提交年度报告。此外，信息学核心将负责MSCP孢子内的所有网络存储和数据共享以及孢子内的协作，并将支持核心A管理的发展研究和职业发展项目。

Translational research such as that proposed in the Melanoma and Skin Program (MSCP) SPORE has a spectrum of needs that benefit from software solutions, including clinical information annotation, data warehousing and disease modeling/analysis tools. The informatics Core (Core D) will serve the Projects and Cores of the MSCP SPORE in the following ways: Project 1. CoThe Informatics Core will be responsible for the data extraction and clinical annotations by the Research Information Service (RIS) to support the E1609 patient cohort and ensure the integration of these data into the Research Data Warehouse (RDW) for use by Biostatistics Core (Core C). Project 2. The Informatics Core will assist in studying the management of the toxicities associated with the treatment in the Project 2 cohorts using our clinical phenotyping tool. This project also requires use the Core D's Clinical Trials Management Application (CTMA) and our clinical annotation expertise provided by the RIS. Of note, CTMA will serve all of the Projects' Clinical Research Management System (CRMS) needs. Project 3. Core D will provide access to the clinical annotation data for Project 3 and make these data available to the SPORE team as well as the Biostatistics Core. The study will collect data electronically from our Electronic Medical Record (EMR) systems and analyze it with our cohort discovery tool (GIANT). The research data generated from this project will also be incorporated into our RDW. Project 4. Core D will develop algorithms (via GIANT) to identify patients with in transit melanoma that may be eligible for inclusion in this project and coordinate the collection of clinical annotations from RIS. Core A (Administrative). The Informatics Core will ensure requisite trial data are recorded, stored, backed up, and available for review and annual reporting by the Project PIs to the Internal and External Advisory Boards and the National Cancer Institute. In addition, the Informatics Core will be responsible for all network storage and data sharing within the MSCP SPORE and for Intra-SPORE collaborations and will support the Developmental Research and Career Development Projects managed in Core A.