National Mesothelioma Virtual Bank for Translational Research

国家间皮瘤转化研究虚拟银行

• 批准号: 7684024
• 负责人: MICHAEL JOHN BECICH
• 金额: $ 100万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7684024
• 关键词: National; Mesothelioma; Virtual; Bank; Translational

DESCRIPTION (provided by applicant): The National Mesothelioma Virtual Bank (NMVB) for Translational Research has created and maintains a national virtual patient registry and research resource bank. To date the NMVB has made available over 400 unique cases to share with the research community. NMVB now proposes to expand their innovative resources through a cooperative working group that broadly shares their mesothelioma research tools. The NMVB database is used for clinical and outcomes data collection related to each research resource (serum, plasma, tissue, pleural effusions, tissue microarrays, whole slide images, proteomic/genomic data and other resources - see specific aim 1). Each NMVB partner will be responsible for the data entry and updates into the registry for each of their research resources on a web based database developed in Pittsburgh which has its foundation in tools from the NCI Cancer Biomedical Informatics Grid (caBIG) effort. The registry has been established and managed by the University of Pittsburgh team in collaboration with New York University, the University of Pennsylvania and the Meso Foundation via a CDC NIOSH cooperative agreement. We intend to significantly expand the network to include the National Functional Genomics Center and the Cooperative Human Tissue Network, as well as other organizations who are interested in sharing their research resources. In addition to actively publicizing the availability of this resource to prospective users in the research community, the Meso Foundation will collaborate with the NMVB to develop a virtual patient registry (see specific aim 2) that will allow researchers to access the patients affected by mesothelioma for clinical and translational research studies. Meso Foundation is well positioned to do this and can capitalize on its deep linkages to the patient advocacy community to create a dialogue with this deeply vested population. Marketing, outreach and evaluation of the NMVB's impact on translational research will be accomplished by partnering with the Meso Foundation (see specific aim 3). In summary, we intend to continue to expand our network to at least 1200 cases for translational research as well as develop a unique patient registry for recruiting those afflicted with mesothelioma. This expansion of the NMVB will provide unique and innovative tools to aid in the prevention, early detection and treatment of this uniformly fatal disease.

描述(由申请人提供)：国家间皮瘤转化性研究虚拟银行(NMVB)已经创建并维护了一个国家虚拟患者登记和研究资源库。到目前为止，NMVB已经提供了400多个独特的案例与研究社区分享。NMVB现在建议通过一个广泛共享他们的间皮瘤研究工具的合作工作组来扩大他们的创新资源。NMVB数据库用于收集与每个研究资源(血清、血浆、组织、胸腔积液、组织微阵列、整个幻灯片图像、蛋白质组/基因组数据和其他资源--见具体目标1)有关的临床和结果数据。每个NMVB合作伙伴将负责将他们在匹兹堡开发的基于网络的数据库上的每个研究资源的数据输入和更新到注册表中，该数据库的基础是NCI癌症生物医学信息网格(CaBIG)的工具。该登记册由匹兹堡大学小组与纽约大学、宾夕法尼亚大学和MESO基金会合作，通过CDC NIOSH合作协议建立和管理。我们打算大幅扩大网络，将国家功能基因组学中心和合作人体组织网络以及其他有兴趣分享其研究资源的组织包括在内。除了积极向研究界的潜在用户宣传这一资源的可用性外，MESO基金会还将与NMVB合作开发一个虚拟患者登记簿(见特定目标2)，使研究人员能够接触到受间皮瘤影响的患者，进行临床和转化性研究。梅索基金会处于有利地位，可以做到这一点，并可以利用其与患者倡导社区的深层联系，与这些根深蒂固的既得利益群体建立对话。营销、推广和评估NMVB对翻译研究的影响将通过与MESO基金会合作完成(见具体目标3)。总而言之，我们打算继续扩大我们的网络，以进行至少1200例翻译研究，并开发一个独特的患者登记系统，以招募间皮瘤患者。NMVB的这一扩展将提供独特和创新的工具，帮助预防、及早发现和治疗这种统一致命的疾病。