Duke Training Grant in Digestive Diseases and Nutrition

描述(由申请人提供)：这是一个T32项目的竞争性续签申请，该项目自1965年以来一直支持杜克大学GI分部的研究培训。该计划的目标仍然是培养拥有博士学位(MD、PhD或MD/PhD)的优秀个人，以开展与胃肠道、胰腺和肝脏疾病的基本机制、治疗和结果相关的独立研究。自2006年最后一次更新资金以来，该项目已从4名医学研究人员(2名男性/2名女性)毕业，他们现在都是杜克大学胃肠科教员的正式成员。每一家都已经从NIH和/或基金会获得了进一步的研究职业发展资金。另外3名MD学员(包括一名亚裔美国女性)将很快完成T32培训支持。所有这些人都将留在杜克继续训练，三人中的两人最近获得了研究拨款，以支持他们继续职业发展。另外两名医学博士(包括一名女性)将于2010年7月进入T32项目。另外两名MD实习生，包括一名非裔美国女性，已被选为2011年7月入学。在此次更新期间，培训计划被重新组织为3个轨道，以更清楚地描述我们三个卓越研究领域的培训计划和师资：基础科学(轨道I)、临床研究(轨道II)和结果研究(轨道III)。它为技术、概念、原则和态度方面的强化培训提供了一个独特的机会，这将使我们的受训人员能够从事胃肠道/肝病的基本机制、治疗和结果的研究。经过我们项目培训的医生和博士将做好最佳准备，在旨在以下目标的转化研究中发挥关键作用：1)使用最先进的分子方法阐明疾病机制；2)对胃肠道/肝脏疾病的诊断和自然病史获得新的临床见解；3)开发胃肠道和肝脏疾病的新治疗方法；以及4)完善临床医生实践和健康提供系统，以优化胃肠道和肝脏疾病的新知识/治疗方法的积极影响。我们项目最近的记录证明，它成功地实现了这些结石，这些结石是推进胃肠道/肝病预防、治疗和治愈的先决条件。 公共卫生相关性：继续为这项研究培训计划提供资金非常重要，因为该计划为医生和博士科学家提供了最先进的研究技能，以及胃肠道(GI)和肝脏的正常生理和疾病状态知识，这对推进GI/肝脏疾病的预防、治疗和最终治愈至关重要。

DESCRIPTION (provided by applicant): This is the competing renewal application for a T32 program that has been supporting research training in the Duke GI Division since 1965. The goal of the program remains to train outstanding individuals with doctoral degrees (MD, PhD, or MD/PhD) to conduct independent investigation relevant to the basic mechanisms, treatment, and outcomes of gastrointestinal, pancreatic, and liver diseases. Since funding was last renewed in 2006, the program has graduated 4 MD researchers (2 men/2 women), all of whom are now full members of the Duke GI Division faculty. Each has already secured further research career development funding from NIH and/or foundations. Another 3 MD trainees (including an Asian American woman) will soon be completing T32 training support. All of these will also remain at Duke to continue training, and two of the three recently won research grants to support their continued career development. Another two MDs (including a woman) will enter the T32 program in July 2010. Two other MD trainees, including an African American woman, have been selected for enrollment in July 2011. During this renewal, the training program has been re-organized into 3 Tracks to more clearly delineate the training programs and faculty in our three areas of research excellence: basic science (Track I), clinical research (Track II) and outcomes research (Track III). It provides a unique opportunity for intensive training in techniques, concepts, principles, and attitudes which will permit our trainees to pursue a career in research into the basic mechanisms, treatments, and outcomes of GI/liver diseases. Physicians and Ph.D.s trained by our program will be optimally prepared to play key roles in translational research aimed at: 1) elucidating disease mechanisms using state of the art molecular approaches; 2) gaining new clinical insights into the diagnosis and natural history of GI/liver diseases; 3) development of new treatment approaches for GI and liver disorders; and 4) refining clinician practice and health delivery systems to optimize the positive impacts of new knowledge/treatments of GI and liver diseases. Our program's recent track record attests to its success at achieving these mile stones that are pre-requisites for advancing prevention, treatment, and cure of GI/liver diseases. PUBLIC HEALTH RELEVANCE: Continued funding for this research training program is important because the program provides physicians and Ph.D. scientists with state-of-the-art research skills, as well as knowledge of the normal physiology and disease states of gastrointestinal (GI) tract and liver, that are vital for advancing the prevention, treatment, and eventual cure of GI/liver diseases.