Macromolecular Structure and Mechanism

高分子结构与机理

• 批准号: 8100456
• 负责人: NIKOLAUS GRIGORIEFF
• 金额: $ 26.51万
• 依托单位: BRANDEIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8100456
• 关键词: Molecular Structure

DESCRIPTION (provided by applicant): Summary This Training Program provides graduate students with advanced education in the principles and practice of macromolecular chemistry, mechanism, and structure. All aspects of the program - formal course curriculum, laboratory rotations, informal specialized area-interest seminars, and intensive research in laboratories operating on the edge of discovery - are aimed at the question: how do biological macromolecules work? How do proteins, membranes, nucleic acids, and high-order complexes of these huge molecules use physical-chemical and structural principles to act in the enormous variety of contexts that underlie biological function? The Training Program provides support for selected graduate students in two of the four life-science graduate Ph.D. programs at Brandeis: Biochemistry, and Biophysics & Structural Biology. The former of these is a more structured program that attracts students mainly with strong academic backgrounds in chemistry and biochemistry backgrounds, while the latter is a more flexible program designed for students who have strong quantitative backgrounds but who may have weaker prior training experience in biological chemistry. Our intention is to bring these two groups of students to the same end-point and to prepare them for careers in basic research. Currently, 28 students (which will rise to 33 students in September 08) are enrolled in these two Ph.D. programs; the Training Program includes 20 participating faculty (in four departments) working in the following areas: macromolecular structure determination by x-ray crystallography and NMR, mechanistic enzymology, membrane transport and ion channel mechanisms, single-molecule analysis, high-resolution mass spectroscopy and proteomics, computational biophysics. RELEVANCE: A general rationale for the value of this program is the conviction that human disease must ultimately be understood in terms of the chemistry and physics of biological macromolecules.

描述（由申请人提供）：摘要本培训计划为研究生提供高分子化学，机理和结构的原理和实践方面的高级教育。该计划的各个方面-正式课程，实验室轮换，非正式的专业领域兴趣研讨会，以及在发现边缘的实验室中进行的密集研究-都针对这个问题：生物大分子如何工作？蛋白质、细胞膜、核酸和这些大分子的高级复合物是如何利用物理化学和结构原理在构成生物功能基础的各种各样的环境中发挥作用的？培训计划为四个生命科学研究生博士学位中的两个的选定研究生提供支持。Brandeis的专业：生物化学，生物物理学和结构生物学。前者是一个更有条理的课程，主要吸引具有化学和生物化学背景的学生，而后者是一个更灵活的课程，专为具有较强定量背景但可能在生物化学方面有较弱培训经验的学生设计。我们的目的是把这两组学生带到同一个终点，并为他们在基础研究的职业生涯做好准备。目前，28名学生（2008年9月将增加到33名学生）就读于这两个博士学位。程序;该培训计划包括20名参与教师（在四个部门）在以下领域工作：通过X射线晶体学和NMR确定大分子结构，机械酶学，膜运输和离子通道机制，单分子分析，高分辨率质谱和蛋白质组学，计算生物物理学。相关性：这个项目的价值的一个基本原理是相信人类疾病最终必须从生物大分子的化学和物理学角度来理解。