Cellular and Molecular Biology at Michigan

描述（由申请人提供）：密歇根大学的细胞和分子生物学（CMB）项目是拉克姆研究生院的一个独立的博士学位授予项目，已有30多年的历史。本课程的目的是培养学生在细胞和分子生物科学方面具有广阔的视野。它是密歇根大学生物医学科学领域最受欢迎的研究生项目之一，在过去的5年中，78名新生进入该项目，另有44名获得博士学位。整个大学的CMB项目利用了医学院、牙科学院、工程学院和文学科学与艺术学院23个部门的教师、课程和研究设施。这种专业知识和机会的多样性使学生在选修课程和强大的研究训练环境方面有最广泛的选择。与此同时，该项目的学生通过灵活的必修课和选修课、强大的学生研讨会、学生组织的短期课程、年度研讨会和海报会议、研究论坛、社会活动和项目服务，分享共同的培训经验。CMB活动为该计划提供了凝聚力，并为大学的学术环境做出了贡献，这些活动受到高度重视，参与人数众多。CMB的108名教职员工的实验室研究项目涵盖了广泛的学科，包括：遗传学，基因组学，基因调控；细胞生物学、生物化学、生理与结构；微生物发病机理;免疫学;发育生物学、神经生物学、衰老学；疾病的分子机制和遗传学。CMB项目是该大学唯一一个针对如此多样化的问题和观点提供培训的实体，鼓励跨学科方法进行基础和转化生物医学研究。CMB项目的持续增长反映了人们对其跨学科方法的兴趣日益增加，并突出了其在大学生物医学科学项目背景下的独特作用。这项提案要求支助20名受训人员，目的是在两年内每年支助10名学生。目前的目标是保持CMB项目的活力，同时保留CMB所知的高质量和个性化培训。相关性：CMB项目的学生进行的研究直接解决了基础科学和临床科学的问题，这些问题对广泛的公共卫生问题具有重要意义，包括癌症、慢性疾病（如糖尿病、类风湿性关节炎）、传染病（如艾滋病、分枝杆菌）和神经退行性疾病（如帕金森病、阿尔茨海默病）。此外，培训将细胞和分子方法应用于各种科学学科的学生，继续增加学术和应用研究领域的杰出科学家人数，他们的工作促进了对人类健康重要的广泛领域的知识。

DESCRIPTION (provided by applicant): The Cellular and Molecular Biology (CMB) Program at the University of Michigan has been a free-standing Ph.D. degree-granting program of the Rackham School of Graduate Studies for over thirty years. The aim of this program is to train students with a broad perspective in cellular and molecular biosciences. It is one of the most popular graduate programs in biomedical sciences at Michigan, and during the past 5 years, 78 new students entered the Program and 44 others received Ph.D. degrees. The University-wide CMB Program draws on faculty, courses and research facilities from 23 departments in the Schools of Medicine, Dentistry, Engineering and the College of Literature Sciences and the Arts. This diversity of expertise and opportunity allows students the broadest possible choice in terms of both elective coursework and strong research training environments. At the same time, students in the Program share a core of common training experiences through a flexible program of required and elective coursework, a strong student seminar program, student-organized short courses, an annual symposium and poster session, a research forum, social events and service to the Program. CMB events provide cohesiveness for the Program and contribute to the intellectual environment of the University as highly regarded and well-attended scientific activities. Research programs in the laboratories of the 108 faculty members in CMB cover a wide range of disciplines, including: genetics, genomics, gene regulation; cell biology, biochemistry, physiology and structure; microbial pathogenesis; immunology; developmental biology, neurobiology, aging; molecular mechanisms and genetics of disease. The CMB Program is the only entity at the University that provides training in such diverse problems and perspectives, encouraging interdisciplinary approaches to both basic and translational biomedical research. The continuing growth of the CMB Program reflects increasing interest in its interdisciplinary approach, and highlights its unique role in the context of the Program in Biomedical Sciences at the University. This proposal requests support for 20 trainees, with the aim of supporting 10 students per year for two years. The current goal is to maintain the vitality of the CMB Program while retaining the high quality and individualized training for which CMB is known. Relevance: The research performed by students in the CMB Program directly addresses problems in both fundamental and clinical sciences that have important implications for a broad array of public health problems, including cancer, chronic (e.g. diabetes, rheumatoid arthritis), infectious (e.g. AIDS, mycobacterial) and neurodegenerative (e.g. Parkinson's, Alzheimer's) diseases. Further, training students who apply cellular and molecular approaches to a wide variety of scientific disciplines continues to add to the population of outstanding scientists in academic and applied research whose work advances knowledge in a wide range of areas important for human health.