Duke Center for Systems Biology

杜克系统生物学中心

• 批准号: 8053052
• 负责人: Philip N Benfey
• 金额: $ 73.22万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8053052
• 关键词: Address; Arabidopsis; Biological; Biology; Cell Cycle; Cell Cycle Regulation; Cells; Cellular Structures; Characteristics; Collaborations; Complex; Development; Educational process of instructing; Embryonic Development; Exposure to; Faculty; Fellowship Program; Fostering; Graduate Education; Imagery; Life; Mammalian Cell; Mathematics; Measures; Methods; Modeling; Molecular; Nonlinear Dynamics; Organism; Physics; Plant Roots; Population; Process; Property; Regulator Genes; Relative (related person); Research; Research Personnel; Research Support; Scientist; Sea Urchins; Structure; Students; System; Systems Biology; Techniques; Variant; Yeast Model System; Yeasts; computer science; design; genetic manipulation; human disease; interdisciplinary approach; programs; statistics; symposium; theories; tool

The Duke Center for Systems Biology (DCSB) will support research collaborations aimed at discovering, modeling, and explaining the dynamical properties of biological networks. Using high throughput techniques, biologists can now determine nearly complete lists of many of the molecular components of cells, measure relative concentrations of these components, and determine which components interact with each other. A major challenge, however, is to understand how this complex network of interactions produces the orchestrated processes characteristic of living cells and higher organisms. DCSB will approach this challenge through interdisciplinary projects involving a wide array of experimental techniques, analysis tools, and modeling methods. Each project will be a collaboration between biologists and theorists with expertise in a relevant subfield of mathematics, computer science, statistics, or physics. DCSB projects will address three broad themes: (1) cell cycle control; (2) development and differentiation; and (3) population variation. In the first two, the emphasis will be on the dynamics determined by gene regulatory networks; in the third, on evolutionary dynamics of network structure. Six initial projects have been identified for support, covering networks involved in various model systems: the yeast cell cycle, mammalian cell cycle entry, Arabidopsis root development, sea urchin embryonic development, population variation in yeast, and population variation in sea urchin. Analysis and modeling efforts will draw from expertise in Bayesian statistics, nonlinear dynamics, computational topology and geometry, and visualization. DCSB will bring together outstanding researchers as collaborators and guest scientists through sabbatical and fellowship programs and through an annual symposium on a current systems biology theme. DCSB faculty will integrate systems biology themes into several existing graduate education programs that foster vertically integrated research teams and exposure to interdisciplinary approaches to biological problems. Faculty associated with DCSB will also teach several new undergraduate systems biology courses and administer a certificate program designed both for biology students and those students in mathematical/computational majors. The results will have substantial implications for treatment of human disease through manipulation of genetic regulatory systems, as well as for fundamental biology and theories of complex systems.

杜克系统生物学中心（DCSB）将支持旨在 发现，建模和解释生物网络的动力学特性。使用高 通过通量技术，生物学家现在可以确定许多分子的几乎完整的列表， 细胞的成分，测量这些成分的相对浓度，并确定 组件之间相互作用。然而，一个主要的挑战是了解这种复杂的 相互作用的网络产生活细胞和更高级细胞的协调过程。 有机体DCSB将通过涉及广泛的跨学科项目来应对这一挑战 一系列实验技术、分析工具和建模方法。每个项目都将是一个 生物学家和具有相关数学子领域专业知识的理论家之间的合作， 计算机科学统计学或物理学DCSB项目将涉及三大主题：（1）细胞 周期控制;（2）发育和分化;（3）种群变异。在前两项中， 重点将是由基因调控网络决定的动态;在第三， 网络结构的演化动力学已经确定了六个初步项目供支助， 涵盖各种模型系统中涉及的网络：酵母细胞周期，哺乳动物细胞周期进入， 拟南芥根的发育，海胆胚胎发育，酵母中的群体变异， 海胆的种群变化分析和建模工作将借鉴贝叶斯的专业知识 统计学、非线性动力学、计算拓扑学和几何学以及可视化。 DCSB将汇集优秀的研究人员作为合作者和客座科学家 通过休假和奖学金计划，并通过一个关于当前系统的年度研讨会， 生物学主题DCSB教师将系统生物学主题整合到现有的几个研究生 教育计划，培养垂直整合的研究团队和接触跨学科 解决生物问题的方法。与DCSB相关的教师还将教授几个新的 本科系统生物学课程，并管理证书课程，既为 生物学专业的学生和数学/计算专业的学生。结果会有 通过操纵基因调控来治疗人类疾病的实质性意义 系统，以及基础生物学和复杂系统理论。