Central Nervous System HIV Translational Research Training Program

中枢神经系统艾滋病毒转化研究培训计划

• 批准号: 8078847
• 负责人: RICHARD W. PRICE
• 金额: $ 13.2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8078847
• 关键词: HIV; Neuraxis; Research Training; Training Programs; Translational Research

DESCRIPTION (provided by applicant): Our understanding of fundamental aspects of the neuropathogenesis of HIV-1 and central nervous system (CNS) opportunistic Infections continues to be limited, and indeed in the current era of combination antiretroviral therapy (cART), the manifestations and likely pathogenesis of HIV-1- and Immunosuppression- related neurological diseases continue to evolve. Thus, further dedicated investigation in the field of neuro- HIV, with a dynamic, multidisciplinary, and international perspective Is of major importance. The objective of this Training Program Is to provide a closely mentored program for physician scientists to develop careers in translational research relevant to the pathogenesis and treatment of HIV infection and associated opportunistic infections in the nervous system. This application seeks support for the UCSF/SFGH CNS HIV Research Fellowship Training Program, a formal clinical and translational research training program supported by a program faculty of 19 established investigators in HIV/AIDS research at UCSF and four extramural members of an external advisory committee. Our multidisciplinary training program includes opportunities in immunology, virology, clinical trials, disease progression, acute HIV, public health, HIV and aging, neuroimaging, and international research. Our three-year training program offers opportunities for both laboratory-based experiences and hypothesis-driven clinical and epidemiologic investigation. Postdoctoral training will be offered to clinically trained scientists with M.D. degrees and prior specialty training. In addition to laboratory or clinical research, trainees will participate in a series of regularly scheduled courses, seminars, journal clubs, conferences, and a seminar series on the responsible conduct of research. Through a carefully selected didactic and educational program, and close monitoring of trainee progress with a formalized mentoring process, trainees will gain the skills to design and execute rigorous investigative projects, analyze their data, and publish their results. Trainees will be guided both by mentors and CTSI and CFAR supported grant-writing workshops and courses in the preparation of extra-mural funding applications, with the goal of obtaining independent career- development awards by the conclusion of the fellowship. The program is designed to train a small number (one new fellow per year) of physician-scientist candidates who are highly motivated to gain expertise in the specialized area of clinical and translational neuro-AIDS research. With abundant resources in the form of study participants, outstanding local collaborators, and educational opportunities, UCSF/SFGH provides an exemplary environment for training in neuro-AIDS, facilitating the establishment of solid and visionary research programs by early-career stage investigators. RELEVANCE: Our understanding of fundamental aspects of the neuropathogenesis of HIV-1 and CNS opportunistic infections continues to be limited, thus, further dedicated investigation in the field of neuro-HIV, with a dynamic, multidisciplinary, international and collaborative perspective, is of major importance. This application seeks support for the UCSF/SFGH CNS HIV Research Fellowship Training Program, a formal clinical and translational research training program for training of future leaders in the field of neurological complications of HIV. The potential of further advancement in the understanding, treatment, and ideally protection against HIV-related neurological disorders is critical for the over 30 million people worldwide living with HIV infection.

描述（由申请人提供）：我们对HIV-1和中枢神经系统（CNS）机会性感染的神经发病机制的基本方面的理解仍然有限，事实上，在当前的联合抗逆转录病毒治疗（cART）时代，HIV-1和免疫抑制相关神经系统疾病的表现和可能的发病机制继续发展。因此，在神经-艾滋病毒领域进行进一步的专门调查，具有动态，多学科和国际视角是非常重要的。该培训计划的目的是为医生科学家提供一个密切指导的计划，以发展与HIV感染和神经系统相关机会性感染的发病机制和治疗相关的转化研究事业。 本申请寻求对UCSF/SFGH CNS HIV研究奖学金培训计划的支持，该计划是一项正式的临床和转化研究培训计划，由UCSF的19名艾滋病毒/艾滋病研究人员和外部咨询委员会的4名校外成员组成的计划教师提供支持。我们的多学科培训计划包括免疫学，病毒学，临床试验，疾病进展，急性艾滋病毒，公共卫生，艾滋病毒和衰老，神经影像学和国际研究的机会。我们为期三年的培训计划为实验室经验和假设驱动的临床和流行病学调查提供了机会。博士后培训将提供给临床培训的科学家与医学博士。学位和先前的专业培训。除了实验室或临床研究，学员将参加一系列定期安排的课程，研讨会，期刊俱乐部，会议和研讨会系列负责任的研究行为。通过精心挑选的教学和教育计划，并通过正式的指导过程密切监测学员的进展，学员将获得设计和执行严格的调查项目，分析数据和发布结果的技能。受训者将由导师指导，并由技术和社会研究所和欧洲基金会支助的编写赠款的讲习班和课程指导，编写校外资助申请，目的是在研究金结束时获得独立的职业发展奖。该计划旨在培养一小部分（每年一名新研究员）医生科学家候选人，他们非常积极地获得临床和转化神经艾滋病研究专业领域的专业知识。以研究参与者，优秀的当地合作者和教育机会的形式丰富的资源，UCSF/SFGH提供了一个神经艾滋病培训的典范环境，促进了早期职业阶段调查人员建立坚实和有远见的研究计划。相关性：我们对HIV-1和CNS机会性感染的神经发病机制的基本方面的理解仍然是有限的，因此，在神经HIV领域的进一步专门调查，具有动态的，多学科的，国际和合作的角度，是非常重要的。该申请寻求对UCSF/SFGH CNS HIV研究奖学金培训计划的支持，该计划是一项正式的临床和转化研究培训计划，旨在培训HIV神经系统并发症领域的未来领导者。进一步促进对艾滋病毒相关神经系统疾病的理解、治疗和理想保护的潜力对全世界3000多万艾滋病毒感染者至关重要。