Central Nervous System HIV Translational Research Training Program

描述(申请人提供)：我们对HIV-1和中枢神经系统(CNS)机会性感染的神经发病机制的基本方面的了解仍然有限，事实上，在当前联合抗逆转录病毒治疗(CART)的时代，与HIV-1和免疫抑制相关的神经系统疾病的表现和可能的发病机制仍在继续演变。因此，以动态的、多学科的和国际的视角对神经艾滋病毒领域进行进一步的专门研究具有重要意义。该培训计划的目标是为内科科学家提供一个密切指导的计划，以便在与HIV感染的发病机制和治疗以及神经系统相关机会性感染相关的翻译研究中发展职业生涯。本申请寻求对UCSF/SFGH CNS HIV研究奖学金培训计划的支持，这是一个正式的临床和翻译研究培训计划，由UCSF 19名艾滋病毒/艾滋病研究方面的资深研究人员和外部咨询委员会的4名校外成员组成的计划学院提供支持。我们的多学科培训计划包括免疫学、病毒学、临床试验、疾病进展、急性艾滋病毒、公共卫生、艾滋病毒与老龄化、神经成像和国际研究方面的机会。我们为期三年的培训计划提供了基于实验室的经验和假设驱动的临床和流行病学调查的机会。博士后培训将提供给具有医学博士学位和以前的专业培训的临床培训的科学家。除了实验室或临床研究，学员还将参加一系列定期安排的课程、研讨会、期刊俱乐部、会议和一系列关于负责任的研究行为的研讨会。通过精心选择的教学和教育计划，以及通过正式的指导过程密切监控学员的进展，学员将获得设计和执行严格的调查项目、分析数据和发布结果的技能。受训人员将在导师以及CTSI和CFAR支助的赠款编写讲习班和课程的指导下准备校外资金申请，目标是在研究金结束时获得独立的职业发展奖。该计划旨在培训一小部分(每年一名新研究员)内科科学家候选人，他们高度有动力获得临床和翻译神经艾滋病研究专业领域的专业知识。加州大学旧金山分校拥有丰富的资源，包括研究参与者、杰出的当地合作者和教育机会，为神经艾滋病培训提供了一个模范环境，促进了职业生涯早期研究人员建立坚实和有远见的研究计划。相关性：我们对艾滋病毒-1和中枢神经系统机会性感染的神经发病机制的基本方面的了解仍然有限，因此，以动态、多学科、国际和合作的视角在神经艾滋病毒领域进行进一步的专门研究具有重要意义。本申请寻求对UCSF/SFGH CNS HIV研究奖学金培训计划的支持，该计划是一个正式的临床和翻译研究培训计划，旨在培训HIV神经并发症领域的未来领导者。对于全世界3000多万艾滋病毒感染者来说，进一步提高对艾滋病毒相关神经疾病的了解、治疗以及理想的预防措施的潜力是至关重要的。

DESCRIPTION (provided by applicant): Our understanding of fundamental aspects of the neuropathogenesis of HIV-1 and central nervous system (CNS) opportunistic Infections continues to be limited, and indeed in the current era of combination antiretroviral therapy (cART), the manifestations and likely pathogenesis of HIV-1- and Immunosuppression- related neurological diseases continue to evolve. Thus, further dedicated investigation in the field of neuro- HIV, with a dynamic, multidisciplinary, and international perspective Is of major importance. The objective of this Training Program Is to provide a closely mentored program for physician scientists to develop careers in translational research relevant to the pathogenesis and treatment of HIV infection and associated opportunistic infections in the nervous system. This application seeks support for the UCSF/SFGH CNS HIV Research Fellowship Training Program, a formal clinical and translational research training program supported by a program faculty of 19 established investigators in HIV/AIDS research at UCSF and four extramural members of an external advisory committee. Our multidisciplinary training program includes opportunities in immunology, virology, clinical trials, disease progression, acute HIV, public health, HIV and aging, neuroimaging, and international research. Our three-year training program offers opportunities for both laboratory-based experiences and hypothesis-driven clinical and epidemiologic investigation. Postdoctoral training will be offered to clinically trained scientists with M.D. degrees and prior specialty training. In addition to laboratory or clinical research, trainees will participate in a series of regularly scheduled courses, seminars, journal clubs, conferences, and a seminar series on the responsible conduct of research. Through a carefully selected didactic and educational program, and close monitoring of trainee progress with a formalized mentoring process, trainees will gain the skills to design and execute rigorous investigative projects, analyze their data, and publish their results. Trainees will be guided both by mentors and CTSI and CFAR supported grant-writing workshops and courses in the preparation of extra-mural funding applications, with the goal of obtaining independent career- development awards by the conclusion of the fellowship. The program is designed to train a small number (one new fellow per year) of physician-scientist candidates who are highly motivated to gain expertise in the specialized area of clinical and translational neuro-AIDS research. With abundant resources in the form of study participants, outstanding local collaborators, and educational opportunities, UCSF/SFGH provides an exemplary environment for training in neuro-AIDS, facilitating the establishment of solid and visionary research programs by early-career stage investigators. RELEVANCE: Our understanding of fundamental aspects of the neuropathogenesis of HIV-1 and CNS opportunistic infections continues to be limited, thus, further dedicated investigation in the field of neuro-HIV, with a dynamic, multidisciplinary, international and collaborative perspective, is of major importance. This application seeks support for the UCSF/SFGH CNS HIV Research Fellowship Training Program, a formal clinical and translational research training program for training of future leaders in the field of neurological complications of HIV. The potential of further advancement in the understanding, treatment, and ideally protection against HIV-related neurological disorders is critical for the over 30 million people worldwide living with HIV infection.