Central Nervous System HIV Translational Research Training Program

中枢神经系统艾滋病毒转化研究培训计划

• 批准号: 8012332
• 负责人: RICHARD W. PRICE
• 金额: $ 13.2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8012332
• 关键词: HIV; Neuraxis; Research Training; Training Programs; Translational Research

DESCRIPTION (provided by applicant): Our understanding of fundamental aspects of the neuropathogenesis of HIV-1 and central nervous system (CNS) opportunistic Infections continues to be limited, and indeed in the current era of combination antiretroviral therapy (cART), the manifestations and likely pathogenesis of HIV-1- and Immunosuppression- related neurological diseases continue to evolve. Thus, further dedicated investigation in the field of neuro- HIV, with a dynamic, multidisciplinary, and international perspective Is of major importance. The objective of this Training Program Is to provide a closely mentored program for physician scientists to develop careers in translational research relevant to the pathogenesis and treatment of HIV infection and associated opportunistic infections in the nervous system. This application seeks support for the UCSF/SFGH CNS HIV Research Fellowship Training Program, a formal clinical and translational research training program supported by a program faculty of 19 established investigators in HIV/AIDS research at UCSF and four extramural members of an external advisory committee. Our multidisciplinary training program includes opportunities in immunology, virology, clinical trials, disease progression, acute HIV, public health, HIV and aging, neuroimaging, and international research. Our three-year training program offers opportunities for both laboratory-based experiences and hypothesis-driven clinical and epidemiologic investigation. Postdoctoral training will be offered to clinically trained scientists with M.D. degrees and prior specialty training. In addition to laboratory or clinical research, trainees will participate in a series of regularly scheduled courses, seminars, journal clubs, conferences, and a seminar series on the responsible conduct of research. Through a carefully selected didactic and educational program, and close monitoring of trainee progress with a formalized mentoring process, trainees will gain the skills to design and execute rigorous investigative projects, analyze their data, and publish their results. Trainees will be guided both by mentors and CTSI and CFAR supported grant-writing workshops and courses in the preparation of extra-mural funding applications, with the goal of obtaining independent career- development awards by the conclusion of the fellowship. The program is designed to train a small number (one new fellow per year) of physician-scientist candidates who are highly motivated to gain expertise in the specialized area of clinical and translational neuro-AIDS research. With abundant resources in the form of study participants, outstanding local collaborators, and educational opportunities, UCSF/SFGH provides an exemplary environment for training in neuro-AIDS, facilitating the establishment of solid and visionary research programs by early-career stage investigators. RELEVANCE: Our understanding of fundamental aspects of the neuropathogenesis of HIV-1 and CNS opportunistic infections continues to be limited, thus, further dedicated investigation in the field of neuro-HIV, with a dynamic, multidisciplinary, international and collaborative perspective, is of major importance. This application seeks support for the UCSF/SFGH CNS HIV Research Fellowship Training Program, a formal clinical and translational research training program for training of future leaders in the field of neurological complications of HIV. The potential of further advancement in the understanding, treatment, and ideally protection against HIV-related neurological disorders is critical for the over 30 million people worldwide living with HIV infection.

描述（由申请人提供）：我们对HIV-1和中枢神经系统（CNS）的基本方面的理解，机会性感染仍然受到限制，实际上，在当前的抗逆转录病毒疗法（CART）时代，HIV-1--1---1--和免疫抑制作用的神经疾病的表现和可能的病原体继续进行。因此，具有动态，多学科和国际观点的神经艾滋病毒领域的进一步专门研究至关重要。该培训计划的目的是为医师科学家提供一项密切指导的计划，以发展与艾滋病毒感染和治疗艾滋病毒感染以及神经系统中相关机会性感染有关的转化研究的职业。 该申请寻求支持UCSF/SFGH CNS HIV研究奖学金培训计划，这是一项正式的临床和转化研究培训计划，由19名在UCSF的艾滋病毒/艾滋病研究的著名研究人员和外部咨询委员会的四名外校成员提供支持。我们的多学科培训计划包括免疫学，病毒学，临床试验，疾病进展，急性艾滋病毒，公共卫生，艾滋病毒和衰老，神经影像学和国际研究的机会。我们为期三年的培训计划为基于实验室的经验以及假设驱动的临床和流行病学研究提供了机会。博士后培训将向接受医学博士学位和先前专业培训的临床培训的科学家提供。除实验室或临床研究外，学员还将参加一系列定期安排的课程，研讨会，期刊俱乐部，会议和有关负责任的研究的研讨会系列。通过精心选择的教学和教育计划，并通过正式的指导过程对学员进步进行密切监控，受训人员将获得设计和执行严格的调查项目，分析数据并发布结果的技能。学员将受到导师的指导，CTSI和CFAR和CFAR支持赠款写作研讨会和课程，以准备外交筹资申请，目的是通过奖学金结束获得独立的职业发展奖项。该计划旨在培训少量（每年一个新的研究员）的医师科学家候选人，他们有积极地在临床和转化神经辅导研究专业领域获得专业知识。 UCSF/SFGH以研究参与者，杰出的本地合作者和教育机会的形式大量资源提供了一个典范的环境，以培训神经辅助工具，从而促进了早期培训者阶段调查人员的建立稳固和有远见的研究计划。相关性：我们对HIV-1和CNS机会主义感染神经发生的基本方面的理解继续受到限制，因此，在神经HIV领域的进一步专门研究，具有动态，多学科，国际和协作观点，这一点非常重要。该应用程序寻求支持UCSF/SFGH CNS HIV研究奖学金培训计划，这是一项正式的临床和转化研究培训计划，用于培训HIV神经系统并发症领域的未来领导者。进一步发展在理解，治疗以及对与HIV相关的神经系统疾病的理想保护方面的潜力对于全球超过3000万人感染了HIV感染至关重要。