Central Nervous System HIV Translational Research Training Program

中枢神经系统艾滋病毒转化研究培训计划

• 批准号: 8520397
• 负责人: RICHARD W. PRICE
• 金额: $ 18.5万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8520397
• 关键词: HIV; Neuraxis; Research Training; Training Programs; Translational Research

DESCRIPTION (provided by applicant): Our understanding of fundamental aspects of the neuropathogenesis of HIV-1 and central nervous system (CNS) opportunistic Infections continues to be limited, and indeed in the current era of combination antiretroviral therapy (cART), the manifestations and likely pathogenesis of HIV-1- and Immunosuppression- related neurological diseases continue to evolve. Thus, further dedicated investigation in the field of neuro- HIV, with a dynamic, multidisciplinary, and international perspective Is of major importance. The objective of this Training Program Is to provide a closely mentored program for physician scientists to develop careers in translational research relevant to the pathogenesis and treatment of HIV infection and associated opportunistic infections in the nervous system. This application seeks support for the UCSF/SFGH CNS HIV Research Fellowship Training Program, a formal clinical and translational research training program supported by a program faculty of 19 established investigators in HIV/AIDS research at UCSF and four extramural members of an external advisory committee. Our multidisciplinary training program includes opportunities in immunology, virology, clinical trials, disease progression, acute HIV, public health, HIV and aging, neuroimaging, and international research. Our three-year training program offers opportunities for both laboratory-based experiences and hypothesis-driven clinical and epidemiologic investigation. Postdoctoral training will be offered to clinically trained scientists with M.D. degrees and prior specialty training. In addition to laboratory or clinical research, trainees will participate in a series of regularly scheduled courses, seminars, journal clubs, conferences, and a seminar series on the responsible conduct of research. Through a carefully selected didactic and educational program, and close monitoring of trainee progress with a formalized mentoring process, trainees will gain the skills to design and execute rigorous investigative projects, analyze their data, and publish their results. Trainees will be guided both by mentors and CTSI and CFAR supported grant-writing workshops and courses in the preparation of extra-mural funding applications, with the goal of obtaining independent career- development awards by the conclusion of the fellowship. The program is designed to train a small number (one new fellow per year) of physician-scientist candidates who are highly motivated to gain expertise in the specialized area of clinical and translational neuro-AIDS research. With abundant resources in the form of study participants, outstanding local collaborators, and educational opportunities, UCSF/SFGH provides an exemplary environment for training in neuro-AIDS, facilitating the establishment of solid and visionary research programs by early-career stage investigators. RELEVANCE: Our understanding of fundamental aspects of the neuropathogenesis of HIV-1 and CNS opportunistic infections continues to be limited, thus, further dedicated investigation in the field of neuro-HIV, with a dynamic, multidisciplinary, international and collaborative perspective, is of major importance. This application seeks support for the UCSF/SFGH CNS HIV Research Fellowship Training Program, a formal clinical and translational research training program for training of future leaders in the field of neurological complications of HIV. The potential of further advancement in the understanding, treatment, and ideally protection against HIV-related neurological disorders is critical for the over 30 million people worldwide living with HIV infection.

描述（由申请人提供）：我们对HIV-1和中枢神经系统（CNS）机会性感染的神经发病机制的基本方面的理解仍然有限，事实上，在当前联合抗逆转录病毒治疗（cART）的时代，HIV-1和免疫抑制相关的神经系统疾病的表现和可能的发病机制继续发展。因此，以动态的、多学科的、国际化的视角，进一步致力于神经HIV领域的研究是非常重要的。该培训计划的目标是为内科科学家提供一个密切指导的计划，以发展与艾滋病毒感染和相关神经系统机会性感染的发病机制和治疗相关的转化研究事业。此申请为UCSF/SFGH CNS HIV研究奖学金培训项目寻求支持，这是一个正式的临床和转化研究培训项目，由UCSF的19名HIV/AIDS研究人员和4名外部咨询委员会的外部成员组成的项目教师提供支持。我们的多学科培训项目包括免疫学、病毒学、临床试验、疾病进展、急性艾滋病毒、公共卫生、艾滋病毒与衰老、神经影像学和国际研究。我们为期三年的培训计划为实验室经验和假设驱动的临床和流行病学调查提供了机会。博士后培训将提供给临床训练有素的具有医学博士学位和先前专业培训的科学家。除了实验室或临床研究外，受训者还将参加一系列定期安排的课程、研讨会、期刊俱乐部、会议和一系列关于负责任的研究行为的研讨会。通过精心挑选的教学和教育计划，并通过正式的指导过程密切监测学员的进展，学员将获得设计和执行严格的调查项目、分析数据和发布结果的技能。受训者将在导师、科技创新中心和基金资助计划支持的赠款写作讲习班和课程的指导下，准备校外资金申请，目标是在研究金结束时获得独立的职业发展奖项。该项目旨在培养少数（每年一名新研究员）的医师科学家候选人，他们在临床和转化神经艾滋病研究的专业领域获得了高度的动力。UCSF/SFGH拥有丰富的研究参与者资源，优秀的当地合作者和教育机会，为神经艾滋病培训提供了一个典范的环境，促进了早期职业研究者建立坚实而有远见的研究项目。相关性：我们对HIV-1和中枢神经系统机会性感染的神经发病机制的基本方面的理解仍然有限，因此，在神经- hiv领域进一步的专门研究，具有动态的、多学科的、国际的和合作的观点，是非常重要的。此申请寻求对UCSF/SFGH CNS HIV研究奖学金培训计划的支持，这是一项正式的临床和转化研究培训计划，旨在培训HIV神经系统并发症领域的未来领导者。在了解、治疗和理想保护艾滋病相关神经系统疾病方面取得进一步进展的潜力对全世界3000多万艾滋病毒感染者至关重要。