Midcareer Investigator Award in Patient-Oriented Research (K24)

描述（由申请人提供）：目标。近期和长期目标是：1)成为肝病相关转化、临床和基础研究的领导者；2)培养下一代从事胃肠道和肝脏疾病研究的内科科学家。我致力于加强医学生、住院医师、研究员和初级教员在研究方面的教育培训，促进以患者为导向的研究的发展。研究项目。在这个申请中，我包括了两个以患者为导向的研究项目，它们来自我目前的HCV中心资助和使用Virahep-C队列的R01资助。这两个不同的、特征鲜明的队列被包括在内，以展示未来受训者可获得的各种研究。我们研究的中心目标是了解控制HCV感染恢复的免疫因素，无论是自发的还是治疗诱导的。这里提出的新研究的目的是回答在实施资助项目过程中出现的其他问题。

DESCRIPTION (provided by applicant): Goals. Immediate and long-term objectives are: 1) to be established as a leader in translational, clinical, and basic research related to liver disease; and 2) to train the next generation of physician-scientists working in gastrointestinal and liver disease. 1 am committed to enhancing the educational training of medical students, residents, fellows, and junior faculty members in research and facilitate the growth of patient-oriented research. Research Project. In this application, 1 have included two patient-oriented research projects that stem from my current HCV Center Grant and an R01 grant using the Virahep-C cohort. These two distinct, well-characterized cohorts are included to demonstrate the variety of research that would be available for future trainees. The central goal of our research is to understand the immune factors that govern recovery from HCV infection, either spontaneously or therapy-induced. The purpose of the new research proposed here is to answer additional questions that have arisen in the course of carrying out the funded projects. Development plan. To date, the majority of individuals I have mentored (11 of 12) have pursued academic careers. Support from this K24 will release me from clinical and administrative responsibilities and allow me to mentor of more trainees and explore the many collaborative opportunities within the outstanding scientific community at UCHSC. Research environment. The studies outlined in this proposal will be performed in Dr. Rosen's lab, 2,707 sq ft on the 10th floor of UCDs Research Complex 2. The laboratory contains biohazard laminar flow hoods, cell culture C02 incubators, inverted and upright microscopes, containment centrifuges, -70oC and liquid nitrogen freezers, and standard PCR equipment. The lab also houses a FACS Aria, Luminex system, and an AID automated ELISPOT reader. Adjacent space is available for molecular biology and protein expression work. A wide variety of shared equipment is available through the Gl Division and the Colorado Center for AIDs Research (CFAR), including flow cytometers and cell sorters (Flow Cytometry Core), high speed and ultracentrifuges, gamma and beta counters, cell harvesters, fluorescent microscope, FPLC, and automated ABI 377 sequencer. RELEVANCE: Approximately 200 million throughout the world have chronic HCV infection, and a large proportion of patients fail to respond to antiviral treatment. This K24 will enhance my ability to mentor junior investigators and will provide the groundwork for novel immunotherapeutic approaches of this common disease.