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Midcareer Investigator Award in Patient-Oriented Research (K24)

以患者为导向的研究中的职业中期研究者奖 (K24)

基本信息

批准号：
8497578
负责人：
HUGO Ramon ROSEN
金额：
$ 19.14万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-18 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8497578
关键词：
Acute Antiviral Agents Antiviral Therapy Avidity Basic Science Biohazardous Substance Cell Culture Techniques Cells Chronic Hepatitis C Clinical Clinical Research Colorado Commit Communities Complex Containment Development Plans Disease Environment Equipment Faculty Floor Flow Cytometry Funding Future Gamma counter Gastrointestinal Diseases Goals Grant Growth Hepatitis C Hepatitis C virus Housing Immune Immunotherapeutic agent Incubators Individual Infection Laboratories Liquid substance Liver diseases Medical Students Mentors Microscope Midcareer Investigator Award in Patient-Oriented Research Molecular Biology Nitrogen Outcome Patients Physicians Reader Recovery Research Research Personnel Research Project Grants Scientist Speed System T-Cell Receptor Training Translational Research Viral Work beta counter career cohort cross reactivity enzyme linked immunospot assay fast protein liquid chromatography fluorescence microscope member next generation novel patient oriented research protein expression square foot stem

项目摘要

Goals. Immediate and long-term objectives are: 1) to be established as a leader in translational, clinical, and basic research related to liver disease; and 2) to train the next generation of physician-scientists working in gastrointestinal and liver disease. 1 am committed to enhancing the educational training of medical students, residents, fellows, and junior faculty members in research and facilitate the growth of patient-oriented research. Research Project. In this application, 1 have included two patient-oriented research projects that stem from my current HCV Center Grant and an ROl grant using the Virahep-C cohort. These two distinct, well-characterized cohorts are included to demonstrate the variety of research that would be available for future trainees. The central goal of our research is to understand the immune factors that govern recovery from HCV infection, either spontaneously or therapy-induced. The purpose ofthe new research proposed here is to answer additional questions that have arisen in the course of carrying out the funded projects. Development plan. To date, the majority of individuals I have mentored (11 of 12) have pursued academic careers. Support from this K24 will release me from clinical and administrative responsibilities and allow me to mentor of more trainees and explore the many collaborative opportunities within the outstanding scientific community at UCHSC. Research environment. The studies outlined in this proposal will be performed in Dr. Rosen's lab, 2,707 sq ft on the 10th floor of UCDs Research Complex 2. The laboratory contains biohazard laminar flow hoods, cell culture C02 incubators, inverted and upright upright microscopes, containment centrifuges, -70 C and liquid nitrogen freezers, and standard PCR equipment. The lab also houses a FACS Aria, Luminex system, and an AID automated ELISPOT reader. Adjacent space is available for molecular biology and protein expression work. A wide variety of shared equipment is available through the Gl Division and the Colorado Center for AIDs Research (CFAR), including flow cytometers and cell sorters (Flow Cytometry Core), high speed and ultracentrifuges, gamma and beta counters, cell harvesters, fluorescent microscope, FPLC, and automated ABI 377 sequencer.

目标.近期和长期目标是：1）成为翻译，临床和与肝脏疾病相关的基础研究; 2）培养下一代从事肝脏疾病研究的医生-科学家。胃肠道和肝脏疾病。我致力于加强医学生的教育培训，研究中的住院医师、研究员和初级教职员工，并促进以患者为导向的研究的发展。研究项目。在这份申请中，我包括了两个以病人为导向的研究项目，这些项目源于我的目前的HCV中心资助和使用Virahep-C群组的ROl资助。这两种截然不同的，特征鲜明的纳入队列是为了展示未来学员可使用的各种研究。的我们研究的中心目标是了解控制HCV感染恢复的免疫因素，自发的或治疗诱导的。本文提出的新研究的目的是回答额外的在执行资助项目过程中出现的问题。发展规划到目前为止，我指导过的大多数人（12人中的11人）都在追求学术 careers.来自K24的支持将使我从临床和管理职责中解脱出来，指导更多的学员，并在优秀的科学领域内探索许多合作机会。在UCHSC。研究环境。本提案中概述的研究将在罗森博士的实验室进行， UCDs研究中心2号10楼。实验室包括生物危害层流罩，细胞培养 CO2培养箱、倒置和直立显微镜、密闭离心机、-70 ℃和液氮冷冻机和标准PCR设备。该实验室还设有一个FACS Aria，Luminex系统和一个自动化的AID ELISPOT读者。邻近的空间可用于分子生物学和蛋白质表达工作。各种各样通过GI部门和科罗拉多艾滋病研究中心（CFAR），包括流式细胞仪和细胞分选仪（流式细胞仪核心）、高速和超浓缩仪、γ和 β计数器、细胞收集器、荧光显微镜、FPLC和自动ABI 377测序仪。