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Midcareer Investigator Award in Patient-Oriented Research (K24)

以患者为导向的研究中的职业生涯中期研究者奖 (K24)

基本信息

批准号：
8305732
负责人：
HUGO Ramon ROSEN
金额：
$ 19.14万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-18 至 2014-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8305732
关键词：
Acute Antiviral Agents Antiviral Therapy Avidity Basic Science Biohazardous Substance Cell Culture Techniques Cells Chronic Hepatitis C Clinical Clinical Research Colorado Commit Communities Complex Containment Development Plans Disease Environment Equipment Faculty Floor Flow Cytometry Funding Future Gamma counter Gastrointestinal Diseases Goals Grant Growth Hepatitis C Hepatitis C virus Housing Immune Immunotherapeutic agent Incubators Individual Infection Laboratories Liquid substance Liver diseases Medical Students Mentors Microscope Midcareer Investigator Award in Patient-Oriented Research Molecular Biology Nitrogen Outcome Patients Physicians Reader Recovery Research Research Personnel Research Project Grants Scientist Speed System T-Cell Receptor Training Translational Research Viral Work beta counter career cohort cross reactivity enzyme linked immunospot assay fast protein liquid chromatography fluorescence microscope member next generation novel patient oriented research protein expression square foot stem

项目摘要

Goals. Immediate and long-term objectives are: 1) to be established as a leader in translational, clinical, and basic research related to liver disease; and 2) to train the next generation of physician-scientists working in gastrointestinal and liver disease. 1 am committed to enhancing the educational training of medical students, residents, fellows, and junior faculty members in research and facilitate the growth of patient-oriented research. Research Project. In this application, 1 have included two patient-oriented research projects that stem from my current HCV Center Grant and an ROl grant using the Virahep-C cohort. These two distinct, well-characterized cohorts are included to demonstrate the variety of research that would be available for future trainees. The central goal of our research is to understand the immune factors that govern recovery from HCV infection, either spontaneously or therapy-induced. The purpose ofthe new research proposed here is to answer additional questions that have arisen in the course of carrying out the funded projects. Development plan. To date, the majority of individuals I have mentored (11 of 12) have pursued academic careers. Support from this K24 will release me from clinical and administrative responsibilities and allow me to mentor of more trainees and explore the many collaborative opportunities within the outstanding scientific community at UCHSC. Research environment. The studies outlined in this proposal will be performed in Dr. Rosen's lab, 2,707 sq ft on the 10th floor of UCDs Research Complex 2. The laboratory contains biohazard laminar flow hoods, cell culture C02 incubators, inverted and upright upright microscopes, containment centrifuges, -70 C and liquid nitrogen freezers, and standard PCR equipment. The lab also houses a FACS Aria, Luminex system, and an AID automated ELISPOT reader. Adjacent space is available for molecular biology and protein expression work. A wide variety of shared equipment is available through the Gl Division and the Colorado Center for AIDs Research (CFAR), including flow cytometers and cell sorters (Flow Cytometry Core), high speed and ultracentrifuges, gamma and beta counters, cell harvesters, fluorescent microscope, FPLC, and automated ABI 377 sequencer.

的目标。近期和长期目标是：1)成为转化、临床和医学领域的领导者