Short-Term Training to Increase the Diversity Pipeline in Heart/Lung/Blood Resear

短期培训以增加心/肺/血液研究的多样性管道

• 批准号: 8154947
• 负责人: MARLYS Hearst WITTE
• 金额: $ 23.69万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8154947
• 关键词: Area; Arizona; Attitude; Basic Science; Biocompatible Materials; Bioinformatics; Biology; Biomedical Engineering; Biomedical Research; Blood; Brain; Cardiovascular system; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Communication; Communities; Complex; Computer Simulation; Curiosities; Databases; Development; Development Plans; Disadvantaged; Educational Curriculum; Educational workshop; Effectiveness; Equilibrium; Esapent; Evaluation; Faculty; Fostering; Future; Genomics; Goals; Health; Health Professional; Heart; Heart Diseases; Hematological Disease; Hematopoietic Neoplasms; Hypertrophy; Image; In Situ; In Vitro; Individual; Institutes; Institution; Interdisciplinary Study; International; Knowledge; Laboratories; Leadership; Link; Lung; Malignant Neoplasms; Medical; Medical Research; Medical Students; Medicine; Mentors; Modeling; Molecular Medicine; Monitor; Multimedia; Nature; Neurosciences; Participant; Physicians; Physiology; Population; Productivity; Prosthesis; Proteomics; Ramp; Reaction; Recruitment Activity; Registries; Research; Research Infrastructure; Research Methodology; Research Personnel; Science; Scientist; Specialized Center; Students; Thinking; Time; Training; Training Programs; Translating; Translation Process; Translations; Underrepresented Minority; United States National Institutes of Health; Universities; Visit; base; bench to bedside; career; college; design; experience; high school; in vivo; innovation; interest; lymphology; peer; professor; programs; role model; skills; virtual

DESCRIPTION (provided by applicant): The University of Arizona (UA) College of Medicine Diverse Student Medical Research Program (DSMRP) will introduce, train, and nurture inquiring medical and undergraduate students [including under-represented minorities (URM)] in health-related basic/clinical biomedical research (emphasizing cardiovascular, pulmonary, blood); and encourage subsequent intensive/extensive research experiences to retain and strengthen the diverse student researcher pipeline. We will build on the infrastructure, high level of student and faculty mentor participation, esprit-de-corps, and outstanding trainee productivity of our current medical student and disadvantaged high school student programs to bridge the discontinuous diversity pipeline of entering and exiting students as they advance in training and strive for professional/academic careers. Full-time summer-vacation laboratory/clinical investigations will be integrated into an innovative Curriculum on Medical Ignorance (CMI) concentrated in a Summer Institute (SIMI) and sustained through year-round trainee-related enrichment activities. These include topical workshops, clinical correlations, advanced extracurricular research in a Research Honors Distinction Track, Introduction to Molecular Medicine laboratory practicum, a new progressive "Translating Translation" face-to-face/online curriculum interweaving the known and unknown from bench to bedside to community, research methodology/communications/leadership/responsible conduct seminars, visiting professors, and career advising. CMI fosters attitudes and questioning skills to recognize and deal with the vast shifting world of medical ignorance ["what we know we don't know (research), don't know we don't know(discovery), and think we know but don't (error)"]. A unique Virtual Clinical Research Center with Questionarium forms a centerpiece for training and national/international networking. Organized around expanding UA Specialized Centers of Excellence and departments and overseen by Program Director, Basic-Clinical Science Advisors, and faculty-elected Medical Student Research Committee, research encompasses cross-cutting themes and in vivo, in vitro, in situ, in silico, and modeling approaches to the cardiovascular (CV) system and its disorders (cardiac contractility, hypertrophy, development; genomics/proteomics, imaging, biomaterials, prosthetics; endothelial biology, microcirculatory physiology, lymphology, bioengineering); and interdigitating research in cancer, neurosciences, bioinformatics, and other topics of interest to students. Based on our ~30-year track record and access to diverse/disadvantaged populations reflected in 729 medical students and 474 high school students trained to date, we anticipate that DSMRP will cultivate many diverse scientific physician contributors to the research enterprise and a growing cadre of medical scientist leaders to energize the scanty diversity pipeline of healthcare professionals and translational researchers. Detailed S/T and L/T formative/summative program and participant evaluation including database registry, individual development plans, and career portfolios, will document effectiveness and promote networking. PUBLIC HEALTH RELEVANCE: This proposal will develop and implement a model program to recruit, train and mentor a large number of diverse/disadvantaged (including URM) undergraduates and medical students in biomedical research predominantly targeting heart, lung, blood disorders. We will develop a career pipeline to promote retention and career progression, thereby contributing to the NIH Roadmap goals of creating the diverse clinical research teams of the future and advancing translation of medical discoveries from bench to bedside to community.

描述（由申请人提供）：亚利桑那大学医学院多元化学生医学研究计划（DSMRP）将在与健康相关的基础/临床生物医学研究（强调心血管，肺，血液）方面引进，培训和培养具有探究精神的医学和本科学生[包括代表性不足的少数民族（URM）]；并鼓励后续的密集/广泛的研究经验，以保留和加强多样化的学生研究人员管道。我们将以基础设施、高水平的学生和教师导师参与、团队精神以及当前医学院学生和弱势高中学生项目的优秀实习生生产力为基础，在学生在培训和职业/学术生涯中取得进步和努力的过程中，弥合新生和退出学生不间断的多样性管道。全日制暑期实验室/临床调查将整合到一个创新的医学无知课程（CMI）中，集中在一个暑期研究所（SIMI），并通过全年与学员相关的丰富活动持续下去。其中包括专题研讨会，临床相关性，高级课外研究的研究荣誉区分轨道，介绍分子医学实验室实习，一个新的进步的“翻译翻译”面对面/在线课程交织已知和未知的从实验室到床边到社区，研究方法/沟通/领导/负责任的行为研讨会，访问教授和职业咨询。CMI培养态度和提问技巧，以认识和应对不断变化的医学无知世界[“我们知道我们不知道的（研究），不知道我们不知道的（发现），认为我们知道但不知道的（错误）”]。一个独特的虚拟临床研究中心与问卷调查形成了培训和国家/国际网络的核心。围绕扩大UA专业卓越中心和部门，由项目主任，基础临床科学顾问和教师选举的医学生研究委员会监督，研究包括跨领域主题和体内，体外，原位，计算机和心血管（CV）系统及其疾病（心脏收缩，肥大，发育，基因组学/蛋白质组学，成像，生物材料，义肢）的建模方法。内皮生物学、微循环生理学、淋巴学、生物工程)；并在癌症、神经科学、生物信息学和其他学生感兴趣的主题方面进行交叉研究。根据我们近30年的跟踪记录和对729名医学生和474名高中学生的不同/弱势群体的访问，我们预计DSMRP将培养许多不同的科学医生，为研究事业做出贡献，并培养越来越多的医学科学家领导干部，以激励医疗保健专业人员和转化研究人员稀少的多样性管道。详细的S/T和L/T形成性/总结性计划和参与者评估，包括数据库注册、个人发展计划和职业组合，将记录有效性并促进网络。