Phase III COBRE: Multimodal Imaging of Neuropsychiatric Disorders (MIND)

III 期 COBRE：神经精神疾病 (MIND) 的多模态成像

• 批准号: 10372242
• 负责人: Andrew Robert Mayer
• 金额: $ 37.39万
• 依托单位: LOVELACE BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-18 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10372242
• 关键词: Algorithmic Analysis; Appointment; Area; Awareness; Biology; Biometry; Bipolar Depression; Bipolar Disorder; Brain; Brain Diseases; Brain imaging; Businesses; Centers of Research Excellence; Chemistry; Classification; Collaborations; Communities; Complex; Computers; Core Facility; Data; Data Analyses; Department of Energy; Development; Devices; Diffusion Magnetic Resonance Imaging; Dimensions; Disease; Electroencephalography; Engineering; Ensure; Environment; Equipment; Faculty; Functional Magnetic Resonance Imaging; Funding; Funding Agency; Genetic; Goals; Grant; Image; Image Analysis; Imaging technology; Individual; Infrastructure; Institution; Interdisciplinary Study; Leadership; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetoencephalography; Major Depressive Disorder; Mental Depression; Mental disorders; Mentors; Methods; Mind-Body Method; Mission; Multimodal Imaging; Neurobiology; Neurologic; Neurosciences; New Mexico; Paper; Patients; Peer Review; Phase; Pilot Projects; Positioning Attribute; Principal Investigator; Program Development; Psychiatry; Publications; Recording of previous events; Research; Research Domain Criteria; Research Personnel; Research Project Grants; Research Training; Resources; Role; Schizophrenia; Seeds; Site; Structure; System; Teacher Professional Development; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Universities; Vision; base; cohesion; computer science; computerized data processing; data acquisition; data management; deep learning; density; design; distinguished professor; improved; independent component analysis; meetings; multimodal data; multimodality; neuroimaging; neuroinformatics; neuromechanism; neuropsychiatric disorder; programs; tool

Project Summary/Abstract This Phase III (P-III) COBRE project will extend the cores that have been successfully leveraged in our Phase I (P-I) and Phase II (P-II) COBRE projects and sustain these unique resources in New Mexico through the im- plementation of a business plan. Over the past eight years we have built up infrastructure and created a cutting edge brain imaging center, our P-II project is just over half-way through and is even more successful than our P- I was at this point in time. The Mind Research Network (MRN) houses an Elekta Neuromag 306-channel MEG System, a high density EEG lab, a 3T Siemens Trio MRI scanner, and a mobile 1.5T Siemens Avanto MRI scanner. Additional resources include a centralized neuroinformatics system, a strong IT management plan, and state-of-the-art image analysis expertise and tools. This P-III COBRE center will continue our momentum and move the cores we have developed into a position of long term sustainability. We will continue with the technical cores established during the P-II project including multimodal data acquisition (MDA), algorithm and data analy- sis (ADA), and biostatistics and neuro-informatics (BNI). These cores have begun to serve MRN and the greater community, as well as other institutions including extensive collaborations with IDeA funded projects in New Mexico and other states. We believe this P-III COBRE is extremely well-positioned to establish and sustain New Mexico as one of the premier brain imaging sites. We include an extensive pilot project program (PPP) that is built on the successful pilot programs implemented as part of the earlier COBRE phases. This includes an ex- tensive educational, mentoring, and faculty development program to carefully mentor and position faculty who use the cores to maximize their potential to successfully compete for external funding, thus fulfilling the ultimate goals of the COBRE program. 2

项目总结/摘要 第三阶段（P-III）COBRE项目将扩展我们在第三阶段中成功利用的核心 I（P-I）和II（P-II）COBRE项目，并通过以下方式维持新墨西哥州的这些独特资源： 一个商业计划的实施。在过去的八年里，我们建立了基础设施， 边缘脑成像中心，我们的P-II项目刚刚过半，甚至比我们的P- 我当时就在这个时间点。大脑研究网络（MRN）拥有Elekta Neuromag 306通道MEG 系统、高密度EEG实验室、3 T Siemens Trio MRI扫描仪和移动的1.5T Siemens Avanto MRI 扫描仪其他资源包括集中的神经信息学系统，强大的IT管理计划， 最先进的图像分析专业知识和工具。这个P-III COBRE中心将继续我们的势头， 将我们已经开发的核心转移到长期可持续发展的位置。我们将继续技术 在P-II项目期间建立的核心，包括多模式数据采集（MDA）、算法和数据分析， sis（ADA）和生物统计学和神经信息学（BNI）。这些核心已经开始服务于MRN和更大的 社区，以及其他机构，包括与IDEA资助的新项目的广泛合作 墨西哥和其他国家。我们相信这P-III眼镜蛇是非常良好的定位，以建立和维持新的 墨西哥是最重要的脑部成像地点之一。我们包括广泛的试点项目计划（PPP）， 建立在作为COBRE早期阶段的一部分而实施的成功的试点项目的基础上。其中包括一名前 紧张的教育，指导和教师发展计划，认真指导和定位教师谁 利用核心最大限度地发挥其潜力，成功地竞争外部资金，从而实现最终目标， COBRE计划的目标。 2