Pilot Project Program (PPP)

摘要 我们的1期（P-I）/2期（P-II）研究使我们能够通过以下方式定义神经精神疾病的研究： 系统多模态成像的透镜作为聚焦的主题区域。我们觉得我们可以在 考虑到我们目前的发展轨迹，国家一级的中心赠款超过了P-III。在P-I/P-II期间， 强大的最先进的基础设施和强大的研究基础，由成熟的教师和成功毕业的初级PI组成，其中一些人现在担任核心董事和导师，作为我们的P-II和阶段的一部分 3（P-III）COBRE程序（在各个核心中详细说明）。虽然R 01赠款的数量赢得了当地 研究人员满足考虑中心赠款的最低要求，我们仍然需要增加 来自MRN/UNM和NM其他研究机构的R 01数量，以便在全国具有竞争力。的 拟议的试点项目计划（PPP）旨在最大限度地提高我们实现这一目标的能力。PPP将提供资金 三类教员：（1）现有的P-II初级PI和试点项目PI，他们有现有的试点项目，需要进一步支持他们的P-II项目;（2）有强烈建议的初级教员， 将在P-III期间作为新的研究者提供支持;（3）希望将神经影像学作为其临床前或临床研究计划的新组成部分以扩大研究范围的高级教师。我们 每年将为我们的购买力平价拨款250，000美元，其中包括向NIGMS申请的125，000美元 以及每年12.5万美元的机构匹配基金。这笔资金将用于支持多达5个项目， 5万美元/项目/年。为了鼓励生产力，每个项目将一次获得1年的资助，如果符合书面标准并经过指导委员会（SC）的评估，则有可能进行竞争性更新。 PPP将为每位成功的PPP研究者制定关于使用核心的培训计划，并将 实施一项指导计划，让人想起我们的P-II指导计划，为所有3类受资助的教职员工提供指导。选择PPP支持的调查人员和监督我们的PPP 将由我们的P-II内部教师发展委员会成员组成的SC进行沿着， 一个管理成员和三个核心用户。 2

ABSTRACT Our Phase 1 (P-I)/Phase 2 (P-II) effort has enabled us to define the study of neuropsychiatric illness through the lens of systematic multimodal imaging as the thematic area of focus. We feel that we can be competitive at the national level for a center grant beyond the P-III given our current trajectory. During P-I/P-II we developed a strong state-of-the-art infrastructure and a strong research base composed of established faculty and successfully graduated junior PIs, some of whom now serve as core directors and mentors as part of our P-II and Phase 3 (P-III) COBRE programs (detailed in the various cores). Although the number of R01 grants won by local investigators meets the minimum requirement for consideration for a center grant, we still need to increase the number of R01s from MRN/UNM and other research institutions in NM in order to be competitive nationally. The proposed Pilot Project Program (PPP) is designed to maximize our ability to achieve this goal. The PPP will fund three categories of faculty members: (1) current P-II junior PIs and pilot project PIs who have existing pilot projects and need further support beyond their P-II projects; (2) junior faculty members with strong proposals who will be supported as new investigators during P-III; and (3) senior faculty members who wish to include neuroimaging as a new component of their pre-clinical or clinical research program to expand the scope of research. We will allocate a total of up to $250,000/year for our PPP, consisting of $125,000/year requested from the NIGMS and $125,000/year in institutional match funds. This funding will be used to support up to 5 projects at $50,000/project/year. To encourage productivity, each project will be funded for 1 year at a time, with the possibility for competitive renewal if meeting documented criteria and after evaluation by the steering committee (SC). The PPP will establish a training program for each successful PPP investigator on the use of the cores and will implement a mentoring program reminiscent of our P-II mentoring program, to provide mentorship to all 3 categories of funded faculty members. The selection of PPP-supported investigators and the oversight of our PPP will be carried out by the SC consisting of members of our P-II internal faculty development committee along with an administrative member and three core users. 2