Pilot Project Program (PPP)

摘要 我们的第一阶段(P-I)/第二阶段(P-II)工作使我们能够通过以下方式定义神经精神疾病的研究 以系统多模式成像的镜头为主题聚焦区域。我们认为我们可以在以下方面具有竞争力 根据我们目前的轨迹，国家层面的中心拨款超过了P-III。在P-I/P-II期间，我们开发了一个 强大的最先进的基础设施和强大的研究基础，由成熟的教员和成功毕业的初级PI组成，其中一些人现在作为我们P-II和阶段的一部分担任核心董事和导师 3(P-III)Cobre方案(详见各核心部分)。虽然当地获得的R01赠款数量 调查人员满足中心拨款的最低考虑要求，我们仍需增加 来自新墨西哥州MRN/UNM和其他研究机构的R01的数量，以便在全国范围内具有竞争力。这个 拟议的试点项目计划(PPP)旨在最大限度地提高我们实现这一目标的能力。购买力平价将为 三类教员：(1)现有的P-II初级绩效指标和试点项目绩效指标，他们有现有的试点项目，并需要在他们的P-II项目之外提供进一步的支持；(2)具有强有力建议的初级教员 将在P-III期间作为新的研究人员得到支持；以及(3)希望将神经成像作为其临床前或临床研究计划的新组成部分以扩大研究范围的资深教职员工。我们 将为我们的PPP分配总计250,000美元/年，其中包括NIGMS要求的125,000美元/年 以及每年12.5万美元的机构匹配基金。这笔资金将用于支持最多5个项目 5万美元/项目/年。为了提高生产率，每个项目将一次资助一年，如果符合文件标准并经过指导委员会(SC)的评估，则有可能进行竞争续签。 PPP将为每一位成功的PPP调查员建立关于使用核心的培训方案，并将 实施一个让人想起我们的P-II辅导计划的辅导计划，为所有3类受资助的教员提供辅导。PPP支持的调查人员的选择和对我们PPP的监督 将由P-II内部教师发展委员会的成员和 一名管理成员和三名核心用户。 2.

ABSTRACT Our Phase 1 (P-I)/Phase 2 (P-II) effort has enabled us to define the study of neuropsychiatric illness through the lens of systematic multimodal imaging as the thematic area of focus. We feel that we can be competitive at the national level for a center grant beyond the P-III given our current trajectory. During P-I/P-II we developed a strong state-of-the-art infrastructure and a strong research base composed of established faculty and successfully graduated junior PIs, some of whom now serve as core directors and mentors as part of our P-II and Phase 3 (P-III) COBRE programs (detailed in the various cores). Although the number of R01 grants won by local investigators meets the minimum requirement for consideration for a center grant, we still need to increase the number of R01s from MRN/UNM and other research institutions in NM in order to be competitive nationally. The proposed Pilot Project Program (PPP) is designed to maximize our ability to achieve this goal. The PPP will fund three categories of faculty members: (1) current P-II junior PIs and pilot project PIs who have existing pilot projects and need further support beyond their P-II projects; (2) junior faculty members with strong proposals who will be supported as new investigators during P-III; and (3) senior faculty members who wish to include neuroimaging as a new component of their pre-clinical or clinical research program to expand the scope of research. We will allocate a total of up to $250,000/year for our PPP, consisting of $125,000/year requested from the NIGMS and $125,000/year in institutional match funds. This funding will be used to support up to 5 projects at $50,000/project/year. To encourage productivity, each project will be funded for 1 year at a time, with the possibility for competitive renewal if meeting documented criteria and after evaluation by the steering committee (SC). The PPP will establish a training program for each successful PPP investigator on the use of the cores and will implement a mentoring program reminiscent of our P-II mentoring program, to provide mentorship to all 3 categories of funded faculty members. The selection of PPP-supported investigators and the oversight of our PPP will be carried out by the SC consisting of members of our P-II internal faculty development committee along with an administrative member and three core users. 2