SELECT SLE CANDIDATE GENES IN AFRICAN AMERICANS

选择非裔美国人中的 SLE 候选基因

• 批准号: 8359792
• 负责人: KENNETH M KAUFMAN
• 金额: $ 21.72万
• 依托单位: OKLAHOMA MEDICAL RESEARCH FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359792
• 关键词: African; African American; American; Asians; Autoimmunity; Bioinformatics; Candidate Disease Gene; Chromosomes, Human, Pair 16; DNA; Ethnic group; Etiology; European; FCGR2A gene; Female; Funding; Genes; Genetic; Genotype; Goals; Grant; Hispanics; ITGAM gene; Individual; Lupus; Maps; Molecular; National Center for Research Resources; PTPN22 gene; Patients; Play; Population; Predisposition; Principal Investigator; Race; Research; Research Infrastructure; Resources; Role; STAT4 gene; Source; Systemic Lupus Erythematosus; TYK2; United States National Institutes of Health; cost; cost effective; genome wide association study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The etiology of Systemic lupus erythematosus involves both environmental and genetic components. A number of genes have been associated with susceptibility to lupus including FCGR2A, PTPN22, STAT4, TYK2 and IRF5. Recently, two whole genome association studies have been completed on European-American female lupus patients. Not only was previous associations confirmed, but a number of new associations were identified (ITGAM, KIAA1542, PXK and BLK). However, it remains unclear if the same, different or additional genes play a role in other ethnic groups, that usually have a more sever form of lupus, such as those of African, Hispanic or Asian descent. In order to more fully understand the similarities and differences between ethnic groups we have performed whole genome association studies on both African-American and European-American populations. To accomplish these studies efficiently, in a more cost effective manner and with a reduction in the bioinformatic burden, we utilized a DNA pooling approach. A gene located on chromosome 16 was identified that showed association in both the European-American and African-American studies. Individual genotyping has confirmed these results. The goal of this study is to further replicate and fine-map the association observed in these racial groups and also identify a potential function that leads to lupus susceptibility.

这个子项目是利用这些资源的众多研究子项目之一