Auditory-articulatory representations for speech production

语音产生的听觉发音表征

• 批准号: 8008805
• 负责人: Bijan Pesaran
• 金额: $ 14.87万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-17 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8008805
• 关键词: Alveolar; Applications Grants; Area; Auditory; Augmentative and Alternative Communication; Behavior; Brain; Code; Collaborations; Communication; Communication impairment; Comprehension; Cues; Data; Electrodes; Electroencephalography; Epilepsy; Exhibits; Future; Goals; Human; Imagery; Inferior frontal gyrus; Intractable Epilepsy; Joints; Knowledge; Language; Maps; Measures; Medical center; Modeling; Monitor; Motor; Movement; Nervous system structure; Neurons; New York; Patients; Perception; Play; Procedures; Process; Production; Prosthesis; Research; Resolution; Role; Sensory; Signal Transduction; Source; Specific qualifier value; Speech; Speech Perception; Stimulus; Surface; System; Techniques; Testing; Universities; Visual; Voice; Work; arm; language processing; millisecond; motor control; motor disorder; neural patterning; neuromechanism; neuroregulation; novel; public health relevance; relating to nervous system; research study; response; speech processing; visual motor

DESCRIPTION (provided by applicant): The long-term goal of this research is to understand the neural representations that guide speech production and perception. While speech and language are central features of human behavior, the neural mechanisms of speech processes remain poorly understood. We will build on recent advances in the neural control of visually-guided reaching to develop analogous models for speech processing. Aim 1 will employ a pseudo- word repetition identification paradigm to test the hypothesis that speech production is encoded in neural activity using an auditory-articulatory representation. Aim 2 will employ a pseudo-word identification paradigm to test the hypothesis that speech perception is encoded using an auditory-articulatory representation. Aim 3 will attempt to replicate findings in Aims 1 and 2 employing a complementary set of pseudo-words. Neural activity will be directly recorded using intracranial electrodes in human patients with pharmacologically- intractable epilepsy. I predict that neural activity in specific cortical areas supporting speech and language will exhibit invariances for particular auditory-articulatory mappings. This will be evidence that speech is processed jointly in auditory space and articulatory space and could explain the specific role of auditory signals in speech production and articulatory signals in speech perception. PUBLIC HEALTH RELEVANCE: Augmentative and alternative communication systems give people with severe communication disorders the ability to communicate. Even after a severe loss of motor function, people can maintain the ability to express themselves with language if they have a communication channel. The long-term goal of this research is to give people with severe motor disorders the ability to speak and communicate by decoding the neural representations that support speech and language processing.

描述（由申请人提供）：这项研究的长期目标是了解指导语音产生和感知的神经表征。虽然语音和语言是人类行为的核心特征，但人们对语音过程的神经机制仍然知之甚少。我们将利用视觉引导神经控制方面的最新进展来开发类似的语音处理模型。目标 1 将采用伪词重复识别范式来测试以下假设：语音产生是使用听觉发音表示在神经活动中编码的。目标 2 将采用伪词识别范式来测试语音感知是使用听觉发音表示进行编码的假设。目标 3 将尝试使用一组互补的伪词来复制目标 1 和 2 中的发现。将使用颅内电极直接记录药物难治性癫痫患者的神经活动。我预测支持语音和语言的特定皮层区域的神经活动将表现出特定听觉-发音映射的不变性。这将证明语音是在听觉空间和发音空间中共同处理的，并且可以解释听觉信号在语音产生中和发音信号在语音感知中的具体作用。 公共卫生相关性：增强性和替代性通信系统为患有严重沟通障碍的人提供了沟通能力。即使运动功能严重丧失，如果有沟通渠道，人们也可以保持用语言表达自己的能力。这项研究的长期目标是通过解码支持语音和语言处理的神经表征，为患有严重运动障碍的人提供说话和交流的能力。