Multiple spatial representations during visually-guided behavior

视觉引导行为期间的多种空间表征

• 批准号: 9237279
• 负责人: Bijan Pesaran
• 金额: $ 37.36万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9237279
• 关键词: Apraxias; Area; Ataxia; Behavior; Behavioral; Brain; Brain Injuries; Chronic; Cognition; Communication; Cues; Data; Disease; Dorsal; Electrodes; Eye Movements; Fire - disasters; Human; Implant; Inferior; Influentials; Injury; Lead; Lobule; Location; Logic; Maps; Measures; Modality; Modeling; Monkeys; Motor; Movement; Neurons; Optics; Parietal; Parietal Lobe; Patients; Perception; Process; Recruitment Activity; Rehabilitation therapy; Role; Saccades; Sensory; Series; Signal Transduction; Specificity; Stream; System; Testing; Vision; Visual; Visuospatial; age related; arm movement; cost; effective therapy; experimental study; gaze; neglect; neural circuit; neural prosthesis; neurodevelopment; nonhuman primate; public health relevance; relating to nervous system; response; social; spatial vision; visual motor; visual stimulus

DESCRIPTION (provided by applicant): Vision is critical for effective control of action. The dorsal stream projects to the posterior parietal cortex (PPC), and transforms visual input into corresponding responses to guide movements of different effectors. An influential model proposes that the dorsal stream is organized into dedicated visuomotor channels that are effector-specific and operate independently. Experiments for this proposal seek to rigorously test this model against alternatives in which channels guide movements of multiple effectors and can interact. We will first test whether coordinating visually-guided behaviors recruits effector-specific processes by recording neurons in the parietal reach system (Aim 1) and the parietal saccade system (Aim 2) during coordinated behavior. We will then test whether channels operate independently or interact by measuring the strength and functional significance of cross-areal coherence between the parietal reach and saccade systems (Aim 3). Despite the central role of coordination to visual behavior, how visual space for reaching and eye movements influence each other and whether cross-areal interactions within PPC underlie this influence is not known. Understanding the mechanisms of coordinated visual behavior will help us understand how visual behavior arises from interactions between different visual representations more generally. Damage to the PPC leads to optic ataxia, apraxia and neglect, is debilitating, and is suffered by many patients each year in the US with significant social costs Understanding how the brain constructs visual-spatial representations underlies the effective treatment of patients with posterior parietal damage.

描述（由申请人提供）：愿景对于有效控制行动至关重要。背侧流投射到后顶叶皮层，将视觉输入转化为相应的反应，引导不同效应器的运动。一个有影响力的模型提出，背流被组织成专用的视觉通道，是特定的效应器和独立运作。该建议的实验旨在严格测试该模型对替代品，其中通道引导多个效应器的运动，并可以相互作用。我们将首先测试是否协调视觉引导的行为招募效应器特定的过程中，通过记录在顶叶到达系统（目标1）和顶叶扫视系统（目标2）在协调的行为。然后，我们将测试通道是否独立运作或相互作用，通过测量顶叶到达和扫视系统之间的跨区域一致性的强度和功能意义（目标3）。尽管协调视觉行为的核心作用，如何达到视觉空间和眼球运动的相互影响，以及跨区域的相互作用是否在PPC这种影响的基础是未知的。理解协调视觉行为的机制将有助于我们更普遍地理解视觉行为是如何从不同视觉表征之间的相互作用中产生的。PPC的损伤导致视共济失调、失用症和忽视，使人衰弱，并且每年在美国有许多患者遭受显著的社会成本。了解大脑如何构建视觉空间表征是有效治疗后顶叶损伤患者的基础。