Multiple spatial representations during visually-guided behavior

视觉引导行为期间的多种空间表征

• 批准号: 8615247
• 负责人: Bijan Pesaran
• 金额: $ 37.15万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8615247
• 关键词: Area; Ataxia; Behavior; Behavioral; Brain; Brain Injuries; Cognition; Communication; Cues; Data; Development; Disease; Dorsal; Electrodes; Eye; Eye Movements; Fire - disasters; Human; Implant; Inferior; Influentials; Injury; Lead; Lobule; Location; Logic; Maps; Measures; Modality; Modeling; Monkeys; Motor; Movement; Neurons; Optics; Parietal; Parietal Lobe; Patients; Perception; Process; Recruitment Activity; Rehabilitation therapy; Role; Saccades; Sensory; Series; Signal Transduction; Specificity; Stream; System; Testing; Vision; Visual; Visuospatial; age related; arm; cost; effective therapy; gaze; neglect; neural circuit; neural prosthesis; nonhuman primate; public health relevance; relating to nervous system; research study; response; social; spatial vision; visual motor; visual stimulus

Project Abstract Vision is critical for effective control of action. The dorsal stream projects to the posterior parietal cortex (PPC), and transforms visual input into corresponding responses to guide movements of different effectors. An influential model proposes that the dorsal stream is organized into dedicated visuomotor channels that are effector-specific and operate independently. Experiments for this proposal seek to rigorously test this model against alternatives in which channels guide movements of multiple effectors and can interact. We will first test whether coordinating visually-guided behaviors recruits effector-specific processes by recording neurons in the parietal reach system (Aim 1) and the parietal saccade system (Aim 2) during coordinated behavior. We will then test whether channels operate independently or interact by measuring the strength and functional significance of cross-areal coherence between the parietal reach and saccade systems (Aim 3). Despite the central role of coordination to visual behavior, how visual space for reaching and eye movements influence each other and whether cross-areal interactions within PPC underlie this influence is not known. Understanding the mechanisms of coordinated visual behavior will help us understand how visual behavior arises from interactions between different visual representations more generally. Damage to the PPC leads to optic ataxia, apraxia and neglect, is debilitating, and is suffered by many patients each year in the US with significant social costs. Understanding how the brain constructs visual-spatial representations underlies the effective treatment of patients with posterior parietal damage.

项目摘要 愿景对于有效控制行动至关重要。背侧流投射到后顶叶皮质（PPC）， 并将视觉输入转换成相应的响应以引导不同效应器的运动。一个 有影响力的模型提出，背流被组织成专用的视觉通道， 效应子特异性和独立操作。针对这一提议的实验试图严格检验这一模型 与通道引导多个效应器的运动并且可以相互作用的替代方案不同。我们将首先测试 协调视觉引导行为是否通过记录大脑中的神经元来招募效应器特异性过程， 顶叶到达系统（目标1）和顶叶扫视系统（目标2）在协调行为。我们将 然后通过测量通道的强度和功能， 顶叶触及和扫视系统之间的跨区域一致性的意义（目的3）。尽管 协调对视觉行为的中心作用，视觉空间如何达到和眼动影响 目前尚不清楚PPC内部的跨区域相互作用是否是这种影响的基础。 理解协调视觉行为的机制将有助于我们理解视觉行为是如何 更一般地，由不同视觉表示之间的交互产生。PPC的损坏导致 视神经共济失调、失用症和忽视症是使人衰弱的，并且在美国每年有许多患者患有这种疾病， 巨大的社会成本。理解大脑如何构建视觉空间表征是 有效治疗后顶骨损伤患者。