Translational Research

转化研究

• 批准号: 8084107
• 负责人: Agnieszka Witkiewicz
• 金额: $ 14.91万
• 依托单位: THOMAS JEFFERSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-03 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8084107
• 关键词: Archives; Biology; Cells; Cellular biology; Clinical; Clinical Data; Databases; Experimental Animal Model; Genetic; Histocompatibility Testing; Hormones; Human; Institutes; Lasers; Malignant Neoplasms; Malignant neoplasm of gastrointestinal tract; Microdissection; Mission; Molecular Analysis; Molecular Biology; Paraffin; Pathologic; Pathology; Preparation; Principal Investigator; Radiation; Research Personnel; Resource Sharing; Resources; Signal Transduction; Slide; Specimen; Staining method; Stains; System; Technology; Tissue Banking; Tissue Banks; Tissue Microarray; Tissues; Translational Research; Tumor Tissue; benefit sharing; cancer Biomedical Informatics Grid; cancer cell; malignant endocrine gland neoplasm; neoplastic; programs; tissue processing

TRANSLATIONAL RESEARCH SHARED RESOURCE Since the inception of the Translational Research Shared Resource (formerly the "Pathology Core") its mission has been to provide tissue processing, slide preparation, histochemical staining and immunohistochemical staining for human neoplastic tissue and experimental animal model tissue being utilized by KCC researchers. This shared resource has also provided procurement, banking and distribution of human neoplastic tissue in order to facilitate translational research. The recently instituted caBIG clinical data base provides pathologic and clinical information corresponding to the tissue specimens present in the resource tumor/tissue bank. In addition, the Translational Research Shared Resource provides tissue microarrays using standard and CEMA technology with paraffin archive material from the resource tumor/tissue bank. Laser microdissection of distinct cell and tissue types for molecular analysis can be performed on the resource's Laser Microdissection system. For all of the capabilities offered by the Translational Research Shared Resource, staff is available to provide technical support and pathology expertise to KCC investigators. In 2006 twenty nine principal investigators from various programs of KCC including Cancer Cell Biology & Signaling, Molecular Biology & Genetics, Immunological Mechanisms in Cancer, Endocrine Mechanisms & Hormone Action in Cancer, Radiation Research & Translational Biology and Gastrointestinal Cancer benefited from this shared resource.

翻译研究共享资源 自转化研究共享资源（前身为“病理学核心”）成立以来，其使命一直是为KCC研究人员使用的人类肿瘤组织和实验动物模型组织提供组织处理、载玻片制备、组织化学染色和免疫组化染色。这一共享资源还提供了人类肿瘤组织的采购、储存和分配，以促进转化研究。最近建立的CABIG临床 数据库提供对应于存在于源肿瘤/组织库中的组织样本的病理和临床信息。此外，转化研究共享资源提供了组织微阵列使用标准和CEMA技术与石蜡档案材料从资源肿瘤/组织库。激光显微切割不同的细胞和组织类型的分子分析可以在资源的激光显微切割系统上进行。提供的所有功能 转化研究共享资源，工作人员可为KCC研究人员提供技术支持和病理学专业知识。2006年，来自KCC各种项目的29名主要研究人员，包括癌症细胞生物学和信号传导，分子生物学和遗传学，癌症免疫机制，癌症内分泌机制和激素作用，辐射研究和转化生物学以及胃肠道癌症受益于这一共享资源。