Impact of ErbB2 and RB Pathways on DCIS Progression and Treatment

ErbB2 和 RB 通路对 DCIS 进展和治疗的影响

• 批准号: 8719057
• 负责人: Agnieszka Witkiewicz
• 金额: $ 31.73万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-16 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8719057
• 关键词: Accounting; Adjuvant; Adjuvant Therapy; Automobile Driving; Breast Carcinoma; Breast-Conserving Surgery; Carcinoma; Clinical; Clinical Data; Clinical Trials; Comedo; Consensus; Cytotoxic Chemotherapy; Data; Diagnosis; Disease; Disease Progression; Disease model; Estrogen receptor negative; Exhibits; Gene Amplification; In Situ Lesion; Incidence; Intervention; Knowledge; Left; Life; Loss of Heterozygosity; Mammary Neoplasms; Modeling; Molecular Profiling; Newly Diagnosed; Noninfiltrating Intraductal Carcinoma; Operative Surgical Procedures; Outcome; Pathway interactions; Patients; Phenotype; Population; Pre-Clinical Model; Prognostic Marker; Publishing; Radiation; Radiation therapy; Recurrence; Reporting; Role; Stratification; Testing; Therapeutic; Tumor Suppressor Genes; Woman; base; cohort; experience; high risk; improved; insight; malignant breast neoplasm; mammary epithelium; overexpression; pre-clinical; prognostic; response; screening; tumor

DESCRIPTION (provided by applicant): Currently ductal carcinoma in situ (DCIS) accounts for 20-30% of newly diagnosed breast cancers in screened populations. Because of the inability to stratify the DCIS populations at high risk for recurrence and disease progression, many women are currently over-treated and approximately 10-15% patients have disease recurrence despite surgical and adjuvant interventions. Preliminary and published data indicate that a large fraction of DCIS lesions exhibits alterations in the ErbB2 and RB-pathways. However there are no studies investigating effects of both pathways abnormalities in the same DCIS lesion. In this application we using functional studies, will: 1. Define role of RB pathway in progression of ErbB2 overexpressing DCIS and 2. Determine how RB and ErbB2 status impacts response to radiation therapy.

描述（由申请人提供）：目前，导管原位癌（DCIS）占筛查人群中新诊断乳腺癌的20-30%。由于无法对复发和疾病进展高风险的DCIS人群进行分层，目前许多女性过度治疗，尽管进行了手术和辅助干预，但约10-15%的患者仍有疾病复发。初步和已发表的数据表明，大部分DCIS病变表现出ErbB 2和RB通路的改变。然而，没有研究调查两种途径异常在同一DCIS病变中的影响。在这个应用中我们使用函数研究，将：1.明确RB通路在ErbB 2过表达DCIS进展中的作用; 2.确定RB和ErbB 2状态如何影响对放射治疗的反应。