Pathology Network Shared Resource

病理网络共享资源

• 批准号: 9923579
• 负责人: Agnieszka Witkiewicz
• 金额: $ 27.52万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9923579
• 关键词: African American; Area; Basic Science; Biological Markers; Breast Carcinoma; Cancer Center Support Grant; Cells; Clinical; Clinical Protocols; Clinical Trials; Collection; Complement; Comprehensive Cancer Center; Consent; Correlative Study; DNA; Data; Data Analyses; Development; Disease; Disease Resistance; Disseminated Malignant Neoplasm; Elements; Freezing; Fresh Tissue; Funding; Future; Genomics Shared Resource; Goals; Grant; Grant Review; Health Service Area; Hematologic Neoplasms; Histology; Human; Image; Image Analysis; Immune; Immunohistochemistry; Immunology; Individual; Industry; Institutional Review Boards; Laboratories; Lead; Leadership; Legal; Malignant Neoplasms; Malignant neoplasm of lung; Metastatic/Recurrent; Methods; Mission; Modeling; Operative Surgical Procedures; Pathogenesis; Pathology; Patients; Peer Review; Play; Preparation; Prevention; Process; RNA; Recurrence; Reporting; Research; Research Design; Research Personnel; Resource Sharing; Resources; Role; Sampling; Savings; Scanning; Science; Services; Site; Slide; Smoker; Solid Neoplasm; Specimen; Spectral Karyotyping; Standardization; System; Technology; The Cancer Genome Atlas; Time; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissues; Translational Research; Tumor Tissue; Work; automated image analysis; biobank; biomarker discovery; biomedical data science; cancer therapy; cell type; cohort; cost; data warehouse; design; functional status; instrumentation; laser capture microdissection; liquid crystal polymer; malignant breast neoplasm; member; non-smoker; operation; precision medicine; sample collection; spatial relationship; symposium; therapy resistant; tool; tumor

The Pathology Network Shared Resource (PNSR) provides human specimens and laboratory services for basic and translational research to further the understanding of the pathogenesis of human cancers and facilitate discovery of biomarkers for new precision medicine approaches. The overall mission of the PNSR is to facilitate collection and access to bio-specimens for research conducted at Roswell Park Comprehensive Cancer Center. The PNSR provides five key service areas: Procurement, Pathology Core Services, Correlative Science Pathology Office, Bio-specimen Bank, and Image Analysis. In the reporting period (2013-2017), the PNSR served a total of 202 Roswell users, of which 131 (88%) were CCSG members. The Specific Aims of the PNSR are: 1) To consent, collect, and store high quality tumor bio specimens. The PNSR oversees the consenting and collection of tumor specimens under a highly standardized process with IRB approval. This includes both routine surgical collections as well as specialized collections of metastatic disease, fresh tissue, or longitudinal collections in accordance with specific clinical protocols; 2) To provide state-of-the-art tissue analyses platforms. The PNSR provides a robust suite of tissue analysis tools to enable the comprehensive analysis of tissues. Standard histology and immunohistochemistry services are complemented by laser capture microdissection and spectral karyotyping; 3) To provide expertise for study design, grant preparation, and clinical trials. Staff within the PNSR plays an active role in designing biomarker studies and rigorous methods for evaluating data that emerges from the analysis of tissues. These integrated features of the PNSR provide an important platform for grant submissions and facilitate development of correlative studies in the context of clinical trials. There are limited options for bio specimen acquisition with the level of quality and annotation that is provided by the PNSR. Acquiring fresh or frozen tissue from external tissue banks is costly, requires considerable legal work (e.g. MTAs), and reliability can be questionable, our costs for these activities in comparison to external sites provide more affordable service for CCSG members. Furthermore, the convenience of these resources is an added benefit to investigators in terms of saving them time and ease of discussion related to design and interpretation of data. Services within the PNSR are accessible to any researcher that has appropriate IRB approval for the proposed work. The PNSR plans to be at the forefront in all areas of operation to facilitate cutting-edge research that will lead to significant changes in the prevention and treatment of cancer. Specialized procurement is critical for this goal given the importance of understanding metastatic, recurrent, and therapy resistant disease.

病理学网络共享资源（PNSR）提供人类标本和实验室服务， 基础和转化研究，以进一步了解人类癌症的发病机制， 为新的精准医学方法发现生物标志物提供便利。PNSR的总体使命是 为在罗斯威尔公园综合医院进行的研究提供生物标本的收集和获取便利 癌症中心PNSR提供五个主要服务领域：采购、病理核心服务、相关 科学病理学办公室，生物标本库和图像分析。在本报告所述期间（2013-2017年）， PNSR共为202名Roswell用户提供服务，其中131名（88%）是CCSG成员。的具体目标 PNSR是：1）同意、收集和储存高质量肿瘤生物标本。PNSR负责监督 同意并在IRB批准的高度标准化流程下采集肿瘤标本。这 包括常规手术收集以及转移性疾病，新鲜组织， 或纵向收集; 2）提供最先进的组织 分析平台。PNSR提供了一套强大的组织分析工具， 组织分析。标准的组织学和免疫组织化学服务由激光辅助 捕获显微切割和光谱核型分析; 3）为研究设计，拨款准备， 和临床试验。PNSR内的工作人员在设计生物标志物研究和严格的 用于评估从组织分析中出现的数据的方法。PNSR的这些综合特征 提供一个重要的平台，供提交赠款，并促进相关研究的发展， 临床试验的背景。生物样本采集的选择有限， 由PNSR提供的注释。从外部组织库获取新鲜或冷冻组织是昂贵的， 需要大量的法律的工作（如MTA），可靠性可能存在疑问，我们在这些活动中的成本 与外部网站相比，为CCSG成员提供了更实惠服务。而且 这些资源的便利性对调查人员来说是一个额外的好处，可以节省他们的时间， 与数据设计和解释有关的讨论。PNSR内的服务可供任何 研究人员，有适当的IRB批准的拟议工作。PNSR计划在以下方面走在前列： * 在所有业务领域促进尖端研究，从而在预防艾滋病毒/艾滋病方面产生重大变化 和治疗癌症。专业化采购对于实现这一目标至关重要，因为 了解转移性、复发性和耐药性疾病。