Liver Pathobiology and Gene Theraphy Research Core Center

肝脏病理学与基因治疗研究核心中心

• 批准号: 7867965
• 负责人: DAVID A SHAFRITZ
• 金额: $ 124.5万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7867965
• 关键词: Liver; Pathobiology; Gene; Theraphy; Research

An interdisciplinary Liver Research Center was established at the Albert Einstein College of Medicine in 1974 with support from NIDDK. At present, 38 faculty investigators and 3 provisional investigators in 12 departments at the medical school, together with 12 Consultants/Collaborators and 5 Supporting Staff Faculty at AECOM, constitute the Liver Research Center. The major objective is to understand fundamental mechanisms of normal liver function, as well as alterations in these function resulting from diseases caused by metabolic, drug, inheritable and infectious (viral) agents. Specific areas under study include transport processes, membrane receptor biology, and structural-functional relationships; molecular biology, somatic gene transfer and gene therapy and mechanisms of hepatic carcinogenesis; hepatic cell transplantation and liver repopulation; liver cell metabolism, mechanisms of liver injury and organelle pathology. By bringing excellent basic scientists into disease related research, together with hepatologists interested in fundamental mechanisms of hepatic dysfunction, we believe that imaginative approaches to basic cell biology, pathophysiology, diagnosis, treatment and prevention of liver disease will emerge. The Center is the focus of an active research-oriented education program (research seminars, visiting scientists, pathobiology sessions and work-in-progress discussion groups), and has extensive collaborative studies with investigators in other institutions. Core facilities, including Molecular Biology and Genetics, Cell Culture and Genetic Engineering, Imaging and Cell Structure, Special Animals and Administrative, efficiently facilitate interdisciplinary research projects. Facilities include 38 well-equipped laboratories for major investigators, 5 core facilities, Animal Institute, and all institutional support services (library, engineering, computer center, etc.). The available clinical facilities include a 1100 bed general hospital (Bronx Municipal Hospital Center), Montefiore Hospital (729 beds) and the Jack D. Weiler Hospital of Albert Einstein College of Medicine (375 beds). A large and diverse patient population provides many individuals with viral, alcoholic and parasitic live disease, as well as various inheritable disorders of the liver. The Center is directed by the Principal Investigator (Dr. David A. Shafritz) and Associate Director (Dr. Allan W. Wolkoff), governed by an Executive Committee, advised and reviewed by a Scientific Advisory Committee and functions through several school-wide committees. The Center was officially chartered by the medical school in 1977 as a free standing, extra- and supra-departmental entity. The importance of the Liver Research Center to the College of Medicine has been reconfirmed by extensive renovation of existing facilities, updating of equipment, an endowment fund and recruitment of new faculty with resources provided by the previous Dean, Dominick P. Purpura, M.D. and the present Dean. Allen Spiegel, M.D.

在NIDDK的支持下，一个跨学科的肝脏研究中心于1974年在爱因斯坦医学院成立。目前，医学院12个院系的38名研究人员和3名临时研究人员与AECOM的12名顾问/合作者和5名辅助教职员工共同组成了肝脏研究中心。主要目标是了解正常肝功能的基本机制，以及由代谢、药物、遗传和感染（病毒）因子引起的疾病对这些功能的改变。具体研究领域包括运输过程、膜受体生物学和结构-功能关系；肝癌发生的分子生物学、体细胞基因转移、基因治疗及机制肝细胞移植与肝脏再生；肝细胞代谢、肝损伤机制及细胞器病理。通过将优秀的基础科学家引入疾病相关研究，以及对肝功能障碍基本机制感兴趣的肝病学家，我们相信，在基础细胞生物学、病理生理学、肝病的诊断、治疗和预防方面，将会出现富有想象力的方法。该中心是一个积极的研究型教育计划的重点（研究研讨会，访问科学家，病理生物学会议和正在进行的讨论小组），并与其他机构的研究人员进行了广泛的合作研究。核心设施，包括分子生物学和遗传学，细胞培养和基因工程，成像和细胞结构，特殊动物和管理，有效地促进跨学科研究项目。设施包括38个设备齐全的主要研究实验室，5个核心设施，动物研究所和所有机构支持服务（图书馆，工程，计算机中心等）。现有的临床设施包括拥有1100张床位的综合医院（布朗克斯市立医院中心）、蒙特菲奥里医院（729张床位）和阿尔伯特·爱因斯坦医学院的杰克·d·韦勒医院（375张床位）。庞大而多样的患者群体为许多人提供了病毒性、酒精性和寄生性活疾病，以及各种遗传性肝脏疾病。该中心由首席研究员（David a . Shafritz博士）和副主任（Allan W. Wolkoff博士）领导，由执行委员会管理，由科学咨询委员会建议和审查，并通过几个全校委员会运作。该中心于1977年正式获得医学院的特许，成为一个独立的、跨部门的实体。肝脏研究中心对医学院的重要性已经通过对现有设施的广泛翻新，设备的更新，捐赠基金和新教师的招聘得到了再次确认，这些资源由前任院长，医学博士多米尼克·p·Purpura和现任院长提供。Allen Spiegel，医学博士