Liver Pathobiology and Gene Therapy Research Core Center

肝脏病理学与基因治疗研究核心中心

• 批准号: 9319719
• 负责人: ALLAN W WOLKOFF
• 金额: $ 125.25万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9319719
• 关键词: Advisory Committees; American; Animal Model; Basic Science; Cause of Death; Cell Transplants; Cellular Structures; Cellular biology; Clinical; Clinical Research; Core Facility; Development; Diagnosis; Disease; Endowment; Equipment; Faculty; Fostering; Functional disorder; Funding; Genetic Engineering; Hepatic; Hospitals; Human; Image; Imagination; Inflammation; Leadership; Liver; Liver Regeneration; Liver diseases; Medicine; Molecular Biology; Philosophy; Prevention; Principal Investigator; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Scientist; Steatohepatitis; Stem cells; Structure; Technology; Therapeutic Studies; Translations; United States; Update; cell growth; college; gene therapy; insight; interdisciplinary approach; interest; liver metabolism; liver transplantation; next generation; novel; stem cell therapy; tool; trafficking

The purposes of the Einstein Liver Research Center (LRC) are to provide strong leadership and direction, catalyze creative basic and translational liver-related research, sustain a collaborative state-of-the-art infrastructure and provide tools and approaches to facilitate the discovery and translation of novel research findings into improvements in treatment and prevention of liver disorders. The Center supports a group of established investigators actively conducting quality research that relate to liver pathobiology and fit into one of our three research foci: 1) Liver Regeneration, Cell Growth Control and Repopulation of the Liver by Transplanted Cells; 2) Pathobiology of Hepatic Transport and Trafficking; 3) Hepatic Metabolism, Inflammation, and Steatohepatitis. By bringing excellent basic scientists into disease-related research, together with hepatologlsts interested in mechanisms of hepatic dysfunction, we believe that imaginative approaches to basic cell biology, pathophysiology, diagnosis, treatment and prevention of liver disease will emerge. Our basic philosophy has been and continues to be, to seek out expertise and help from each other in an open ended fashion in our quest for new understanding of liver structure-function and disease. Core facilities are: A) Animal Models, Stem Cells and Cell Therapy; B) Molecular Biology and Next Generation Technologies; C) Imaging and Cell Structure; D) Genetic Engineering and Gene Therapy; and an Administrative Core. A Clinical Component has been added to the Center provide a platform to bridge new basic research findings to translational advances in the study and treatment of human liver diseases. The Center is directed by the Principal Investigator (Dr. Allan W. Wolkoff) and Associate Director (Dr. David A. Shafritz), governed by an Executive Committee and advised and reviewed by an external Scientific Advisory Committee. The importance of the Liver Research Center to the College of Medicine and hospital center has been reconfirmed by extensive renovation of existing facilities, updating of equipment, an endowment fund and recruitment of new faculty with resources provided by Dean Allen Spiegel, and Montefiore CEO Dr. Steven Safyer.

爱因斯坦肝脏研究中心 (LRC) 的目的是提供强有力的领导和指导， 促进与肝脏相关的创造性基础和转化研究，维持最先进的合作 基础设施并提供工具和方法来促进新颖研究的发现和转化 改善肝脏疾病治疗和预防的发现。该中心支持一批 已建立的研究人员积极开展与肝脏病理学相关的高质量研究，并融入其中 我们的三个研究重点：1) 肝脏再生、细胞生长控制和肝脏再生 移植细胞； 2）肝脏运输和贩运的病理学； 3）肝脏代谢， 炎症和脂肪性肝炎。通过将优秀的基础科学家引入疾病相关研究， 与对肝功能障碍机制感兴趣的肝病专家一起，我们相信富有想象力的 肝病的基础细胞生物学、病理生理学、诊断、治疗和预防方法将 出现。我们的基本理念一直是并将继续是寻求专业知识并互相帮助 以开放式的方式寻求对肝脏结构功能和疾病的新理解。核 设施包括： A) 动物模型、干细胞和细胞疗法； B) 分子生物学和下一代 技术； C) 成像和细胞结构； D) 基因工程和基因治疗；和一个 行政核心。该中心增加了一个临床部分，提供了一个平台来桥接新的 从基础研究成果到人类肝脏疾病研究和治疗的转化进展。这 中心由首席研究员（Allan W. Wolkoff 博士）和副主任（David A. Wolkoff 博士）领导。 Shafritz），由执行委员会管理，并由外部科学顾问提供建议和审查 委员会。肝脏研究中心对医学院和医院中心的重要性 通过对现有设施进行大规模翻新、更新设备、设立捐赠基金等方式再次确认 并利用院长 Allen Spiegel 和 Montefiore 首席执行官 Dr. 提供的资源招聘新教师。 史蒂文·萨菲尔。