Liver Pathobiology and Gene Therapy Research Core Center

总体描述(由申请人提供)：爱因斯坦肝脏研究中心(LRC)的目的是提供强有力的领导和指导，促进创造性的基础和翻译肝脏相关研究，维持最先进的合作基础设施，并提供工具和方法，促进新研究成果的发现和转化，以改善肝病的治疗和预防。该中心支持一群资深研究人员积极开展与肝脏病理生物学相关的高质量研究，这些研究符合我们的三个研究重点之一：1)肝脏再生、细胞生长控制和移植细胞对肝脏的再繁殖；2)肝脏运输和运输的病理生物学；3)肝脏代谢、炎症和脂肪性肝炎。通过将优秀的基础科学家引入疾病相关研究，以及对肝功能障碍机制感兴趣的肝病专家，我们相信将出现基础细胞生物学、病理生理学、肝病诊断、治疗和预防的富有想象力的方法。我们的基本理念一直是，并将继续以开放的方式寻求专业知识和相互帮助，以寻求对肝脏结构-功能和疾病的新理解。核心设施包括：A)动物模型、干细胞和细胞治疗；B)分子生物学和下一代技术；C)成像和细胞结构；D)基因工程和基因治疗；以及行政核心。该中心增加了一个临床部分，提供了一个平台，将新的基础研究成果与人类肝病研究和治疗方面的翻译进展联系起来。该中心由首席调查员(Allan W.Wolkoff博士)和副主任(David A.Shafritz博士)领导，由执行委员会管理，并由外部科学咨询委员会提供建议和审查。肝脏研究中心对医学院和医院中心的重要性再次得到证实，因为它对现有设施进行了广泛的翻新，更新了设备，设立了捐赠基金，并利用院长艾伦·斯皮格尔和蒙特菲奥尔首席执行官史蒂文·萨菲尔博士提供的资源招聘了新的教员。

DESCRIPTION, OVERALL (provided by applicant): The purposes of the Einstein Liver Research Center (LRC) are to provide strong leadership and direction, catalyze creative basic and translational liver-related research, sustain a collaborative state-of-the-art infrastructure ad provide tools and approaches to facilitate the discovery and translation of novel research findings into improvements in treatment and prevention of liver disorders. The Center supports a group of established investigators actively conducting quality research that relate to liver pathobiology and fit into one of our three research foci: 1) Liver Regeneration, Cell Growth Control and Repopulation of the Liver by Transplanted Cells; 2) Pathobiology of Hepatic Transport and Trafficking; 3) Hepatic Metabolism, Inflammation, and Steatohepatitis. By bringing excellent basic scientists into disease-related research, together with hepatologlsts interested in mechanisms of hepatic dysfunction, we believe that imaginative approaches to basic cell biology, pathophysiology, diagnosis, treatment and prevention of liver disease will emerge. Our basic philosophy has been and continues to be, to seek out expertise and help from each other in an open ended fashion in our quest for new understanding of liver structure-function and disease. Core facilities are: A) Animal Models, Stem Cells and Cell Therapy; B) Molecular Biology and Next Generation Technologies; C) Imaging and Cell Structure; D) Genetic Engineering and Gene Therapy; and an Administrative Core. A Clinical Component has been added to the Center provide a platform to bridge new basic research findings to translational advances in the study and treatment of human liver diseases. The Center is directed by the Principal Investigator (Dr. Allan W. Wolkoff) and Associate Director (Dr. David A. Shafritz), governed by an Executive Committee and advised and reviewed by an external Scientific Advisory Committee. The importance of the Liver Research Center to the College of Medicine and hospital center has been reconfirmed by extensive renovation of existing facilities, updating of equipment, an endowment fund and recruitment of new faculty with resources provided by Dean Allen Spiegel, and Montefiore CEO Dr. Steven Safyer.