Liver Pathobiology and Gene Therapy Research Core Center

概述（由申请人提供）：爱因斯坦肝脏研究中心（LRC）的目的是提供强有力的领导和指导，催化创造性的基础和转化肝脏相关研究，维持最先进的协作基础设施，并提供工具和方法，以促进新研究成果的发现和转化，改善肝脏疾病的治疗和预防。该中心支持一组成熟的研究人员积极开展与肝脏病理生物学相关的高质量研究，并符合我们的三个研究重点之一：1)肝脏再生，细胞生长控制和移植细胞的肝脏再生；2)肝脏转运和贩运的病理生物学；3)肝脏代谢、炎症和脂肪性肝炎。通过将优秀的基础科学家引入疾病相关研究，以及对肝功能障碍机制感兴趣的肝病学家，我们相信将出现基础细胞生物学，病理生理学，肝病诊断，治疗和预防的富有想象力的方法。我们的基本理念一直是，并将继续是，在我们对肝脏结构，功能和疾病的新理解的探索中，以开放式的方式寻求彼此的专业知识和帮助。核心设施有：A)动物模型、干细胞和细胞治疗；B)分子生物学与新一代技术；C)成像与细胞结构；D)基因工程与基因治疗；以及行政核心。中心新增了一个临床组成部分，为新的基础研究成果与人类肝脏疾病研究和治疗的转化进展提供了一个平台。该中心由首席研究员（Allan W. Wolkoff博士）和副主任（David A. Shafritz博士）领导，由执行委员会管理，并由外部科学咨询委员会提供建议和审查。肝脏研究中心对医学院和医院中心的重要性已经通过对现有设施的广泛翻新，设备的更新，捐赠基金和新教师的招聘得到了再次确认，这些资源由院长Allen Spiegel和Montefiore首席执行官Steven Safyer博士提供。

DESCRIPTION, OVERALL (provided by applicant): The purposes of the Einstein Liver Research Center (LRC) are to provide strong leadership and direction, catalyze creative basic and translational liver-related research, sustain a collaborative state-of-the-art infrastructure ad provide tools and approaches to facilitate the discovery and translation of novel research findings into improvements in treatment and prevention of liver disorders. The Center supports a group of established investigators actively conducting quality research that relate to liver pathobiology and fit into one of our three research foci: 1) Liver Regeneration, Cell Growth Control and Repopulation of the Liver by Transplanted Cells; 2) Pathobiology of Hepatic Transport and Trafficking; 3) Hepatic Metabolism, Inflammation, and Steatohepatitis. By bringing excellent basic scientists into disease-related research, together with hepatologlsts interested in mechanisms of hepatic dysfunction, we believe that imaginative approaches to basic cell biology, pathophysiology, diagnosis, treatment and prevention of liver disease will emerge. Our basic philosophy has been and continues to be, to seek out expertise and help from each other in an open ended fashion in our quest for new understanding of liver structure-function and disease. Core facilities are: A) Animal Models, Stem Cells and Cell Therapy; B) Molecular Biology and Next Generation Technologies; C) Imaging and Cell Structure; D) Genetic Engineering and Gene Therapy; and an Administrative Core. A Clinical Component has been added to the Center provide a platform to bridge new basic research findings to translational advances in the study and treatment of human liver diseases. The Center is directed by the Principal Investigator (Dr. Allan W. Wolkoff) and Associate Director (Dr. David A. Shafritz), governed by an Executive Committee and advised and reviewed by an external Scientific Advisory Committee. The importance of the Liver Research Center to the College of Medicine and hospital center has been reconfirmed by extensive renovation of existing facilities, updating of equipment, an endowment fund and recruitment of new faculty with resources provided by Dean Allen Spiegel, and Montefiore CEO Dr. Steven Safyer.