Liver Pathobiology and Gene Therapy Research Core Center

肝脏病理学与基因治疗研究核心中心

• 批准号: 8910684
• 负责人: ALLAN W WOLKOFF
• 金额: $ 31.31万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8910684
• 关键词: Liver; Pathobiology; Gene; Therapy; Research

DESCRIPTION, OVERALL (provided by applicant): The purposes of the Einstein Liver Research Center (LRC) are to provide strong leadership and direction, catalyze creative basic and translational liver-related research, sustain a collaborative state-of-the-art infrastructure ad provide tools and approaches to facilitate the discovery and translation of novel research findings into improvements in treatment and prevention of liver disorders. The Center supports a group of established investigators actively conducting quality research that relate to liver pathobiology and fit into one of our three research foci: 1) Liver Regeneration, Cell Growth Control and Repopulation of the Liver by Transplanted Cells; 2) Pathobiology of Hepatic Transport and Trafficking; 3) Hepatic Metabolism, Inflammation, and Steatohepatitis. By bringing excellent basic scientists into disease-related research, together with hepatologlsts interested in mechanisms of hepatic dysfunction, we believe that imaginative approaches to basic cell biology, pathophysiology, diagnosis, treatment and prevention of liver disease will emerge. Our basic philosophy has been and continues to be, to seek out expertise and help from each other in an open ended fashion in our quest for new understanding of liver structure-function and disease. Core facilities are: A) Animal Models, Stem Cells and Cell Therapy; B) Molecular Biology and Next Generation Technologies; C) Imaging and Cell Structure; D) Genetic Engineering and Gene Therapy; and an Administrative Core. A Clinical Component has been added to the Center provide a platform to bridge new basic research findings to translational advances in the study and treatment of human liver diseases. The Center is directed by the Principal Investigator (Dr. Allan W. Wolkoff) and Associate Director (Dr. David A. Shafritz), governed by an Executive Committee and advised and reviewed by an external Scientific Advisory Committee. The importance of the Liver Research Center to the College of Medicine and hospital center has been reconfirmed by extensive renovation of existing facilities, updating of equipment, an endowment fund and recruitment of new faculty with resources provided by Dean Allen Spiegel, and Montefiore CEO Dr. Steven Safyer.

总体描述（由申请人提供）：爱因斯坦肝脏研究中心（LRC）的目的是提供强有力的领导和指导，促进创造性的基础和转化肝脏相关研究，维持最先进的协作基础设施，并提供工具和方法，以促进发现和翻译新的研究成果，以改善肝脏疾病的治疗和预防。该中心支持一组成熟的研究人员积极开展与肝脏病理生物学相关的高质量研究，并适合我们的三个研究重点之一：1）肝再生，细胞生长控制和移植细胞的肝脏再增殖; 2）肝脏运输和运输的病理生物学; 3）肝脏代谢，炎症和脂肪性肝炎。通过将优秀的基础科学家引入疾病相关的研究，以及对肝功能障碍机制感兴趣的肝病学家，我们相信基础细胞生物学，病理生理学，诊断，治疗和预防肝病的富有想象力的方法将会出现。我们的基本理念一直是并将继续是，在我们寻求对肝脏结构-功能和疾病的新理解的过程中，以开放的方式寻求专业知识和相互帮助。核心设施包括：A）动物模型，干细胞和细胞治疗; B）分子生物学和下一代技术; C）成像和细胞结构; D）基因工程和基因治疗;和管理核心。该中心增加了一个临床部分，提供了一个平台，将新的基础研究发现与人类肝脏疾病研究和治疗的转化进展联系起来。该中心是由首席研究员（博士艾伦W。Wolkoff）和副主任（大卫A. Shafritz），由执行委员会管理，并由外部科学咨询委员会提供咨询和审查。肝脏研究中心对医学院和医院中心的重要性通过对现有设施的大规模改造、设备的更新、捐赠基金以及利用院长艾伦·斯皮格尔（Allen Spiegel）提供的资源招聘新教师而得到了再次证实。Montefiore首席执行官Steven Safyer博士。