Liver Pathobiology and Gene Therapy Research Core Center

爱因斯坦肝脏研究中心（LRC）的目的是提供强有力的领导和方向， 促进创造性的基础和转化肝脏相关研究，维持最先进的合作 基础设施，并提供工具和方法，以促进新的研究发现和翻译 研究发现改善治疗和预防肝脏疾病。该中心支持一组 建立了积极开展与肝脏病理生物学相关的高质量研究的研究人员， 我们的三个研究重点：1）肝再生，细胞生长控制和肝脏的再增殖， 移植细胞; 2）肝脏转运和运输的病理生物学; 3）肝脏代谢， 炎症和脂肪性肝炎。通过将优秀的基础科学家引入疾病相关研究， 与对肝功能障碍机制感兴趣的肝病学家一起，我们相信， 基础细胞生物学、病理生理学、诊断、治疗和预防肝病的方法将 出现。我们的基本理念一直是，并将继续是，寻求专业知识和相互帮助 在我们寻求对肝脏结构-功能和疾病的新理解的过程中，核心 设施是：A）动物模型，干细胞和细胞治疗; B）分子生物学和下一代 技术; C）成像和细胞结构; D）基因工程和基因治疗;以及 行政核心。该中心增加了一个临床部分，提供了一个平台， 从基础研究发现到人类肝病研究和治疗的转化进展。的 中心由主要研究者（艾伦W博士）指导。Wolkoff）和副主任（大卫A. Shafritz），由执行委员会管理，并由外部科学顾问提供咨询和审查 以马克思肝脏研究中心对医学院和医院中心的重要性 通过对现有设施的大规模翻新、设备的更新、捐赠基金 和招聘新的教师与院长艾伦斯皮格尔提供的资源，和蒙蒂菲奥雷首席执行官博士。 史蒂文·萨菲尔。

The purposes of the Einstein Liver Research Center (LRC) are to provide strong leadership and direction, catalyze creative basic and translational liver-related research, sustain a collaborative state-of-the-art infrastructure and provide tools and approaches to facilitate the discovery and translation of novel research findings into improvements in treatment and prevention of liver disorders. The Center supports a group of established investigators actively conducting quality research that relate to liver pathobiology and fit into one of our three research foci: 1) Liver Regeneration, Cell Growth Control and Repopulation of the Liver by Transplanted Cells; 2) Pathobiology of Hepatic Transport and Trafficking; 3) Hepatic Metabolism, Inflammation, and Steatohepatitis. By bringing excellent basic scientists into disease-related research, together with hepatologlsts interested in mechanisms of hepatic dysfunction, we believe that imaginative approaches to basic cell biology, pathophysiology, diagnosis, treatment and prevention of liver disease will emerge. Our basic philosophy has been and continues to be, to seek out expertise and help from each other in an open ended fashion in our quest for new understanding of liver structure-function and disease. Core facilities are: A) Animal Models, Stem Cells and Cell Therapy; B) Molecular Biology and Next Generation Technologies; C) Imaging and Cell Structure; D) Genetic Engineering and Gene Therapy; and an Administrative Core. A Clinical Component has been added to the Center provide a platform to bridge new basic research findings to translational advances in the study and treatment of human liver diseases. The Center is directed by the Principal Investigator (Dr. Allan W. Wolkoff) and Associate Director (Dr. David A. Shafritz), governed by an Executive Committee and advised and reviewed by an external Scientific Advisory Committee. The importance of the Liver Research Center to the College of Medicine and hospital center has been reconfirmed by extensive renovation of existing facilities, updating of equipment, an endowment fund and recruitment of new faculty with resources provided by Dean Allen Spiegel, and Montefiore CEO Dr. Steven Safyer.