Field Validation of a Personal Sensor for Ultrafine PM in Asthmatic Children

哮喘儿童超细颗粒物个人传感器的现场验证

• 批准号: 8177520
• 负责人: Patrick H Ryan
• 金额: $ 46.36万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8177520
• 关键词: Activities of Daily Living; Address; Air Pollution; Area; Asthma; Caliber; Caregivers; Characteristics; Child; Childhood; Childhood Asthma; Collaborations; Communities; Data; Detection; Engineering; Enrollment; Environment; Environmental Epidemiology; Epidemiologic Studies; Epidemiologist; Exposure to; Feedback; Funding; Gold; Health; Heart Diseases; Home environment; Human; Human Resources; Laboratories; Lung diseases; Measurement; Measures; Minority; Modeling; Modification; Monitor; Morbidity - disease rate; Nanotechnology; National Institute of Environmental Health Sciences; Occupational; Participant; Particulate; Particulate Matter; Performance; Physical activity; Population; Preparation; Process; Resolution; Respiratory physiology; Sampling; Scanning; School-Age Population; Schools; Side; Site; Son; Source; Symptoms; Testing; Time; Ultrafine; Urban Population; Validation; air monitoring; base; cohort; field study; inner city; innovation; instrument; nervous system disorder; particle; respiratory; satisfaction; sensor; spatiotemporal; trafficking; ultrafine particle; usability

DESCRIPTION (provided by applicant): Epidemiologic studies of the impact of traffic-related air pollution (TRAP) on human health are frequently limited by the use of surrogate, ambient, or modeled exposure. The need for personal monitoring is evident in susceptible subpopulations, particularly children, who spend significant time at schools and in vehicles, in addition to their homes. Further, children may have high levels of physical activity and be in close proximity to particulate sources that result in higher levels of exposure than those recorded at stationary sampling sites. In order to address current limitations in characterizing exposure, a personal and wearable sensor capable of measuring, with high spatiotemporal resolution, exposure to ultrafine particles (UFP) has been developed and validated in laboratory settings. Though the personal sensor was developed to be sufficiently small, rugged, and straightforward to allow its widespread use in epidemiologic studies, it has not been validated outside the laboratory or utilized in the field. Therefore, the objectives of this application are to validate this highly innovative sensor in the field and conduct a field test of the sensor in an ongoing epidemiologic study of TRAP exposure at schools and communities. This study will benefit from the collaboration of engineers and epidemiologists to produce a personal sensor for UFP capable of being utilized in epidemiologic studies. In order to achieve the study objectives, the developed sensor will be validated in the field against current, non- personal, gold-standard instruments. Following the validation of the sensor, a field test of the personal sensor will be conducted within the context of a currently ongoing epidemiologic study, the Cincinnati Anti-Idling Campaign (CAIC) study. Children enrolled in the CAIC attend one of four participating Cincinnati Public Schools with varying exposure to TRAP from nearby roads or school buses. In addition, CAIC participants are asthmatic and have completed an initial health assessment. Exposure to TRAP is currently assessed in the CAIC study through the use of school and community ambient air monitoring. Thus, the CAIC study is ideal to assess the benefit of personal monitoring and to determine the acceptability and usability of the developed sensor in a population of inner-city asthmatic children. The results of the field test will provide feedback in order to modify the sensor in preparation for wide-spread use in epidemiologic studies. PUBLIC HEALTH RELEVANCE: Epidemiologic studies of the impact of traffic-related air pollution (TRAP) on human health are frequently limited by the use of surrogate, ambient, or modeled exposure. In order to address current limitations in characterizing exposure, a personal and wearable sensor capable of measuring, with high spatiotemporal resolution, exposure to ultrafine particles (UFP) has been developed and validated in laboratory settings. The objectives of this application are to validate this highly innovative sensor in the field and conduct a field test of the sensor in an ongoing epidemiologic study of TRAP exposure at schools and communities.

描述（由申请人提供）：关于交通相关空气污染（TRAP）对人类健康的影响的流行病学研究通常受到替代，环境或建模暴露的限制。在易感亚群中，尤其是儿童，他们在学校和车辆上花费大量时光，对个人监测的需求也很明显。此外，儿童的体育锻炼水平可能很高，并且与颗粒源相比，与固定采样位点记录的颗粒源相近。为了解决当前表征暴露的局限性，具有高时空分辨率的个人且可穿戴的传感器，在实验室环境中已经开发并验证了对超细颗粒（UFP）的暴露。尽管开发了个人传感器足够小，坚固且直截了当，以允许其在流行病学研究中广泛使用，但尚未在实验室外验证或在现场使用。因此，本应用程序的目标是验证该领域中高度创新的传感器，并在正在进行的学校和社区陷阱暴露的流行病学研究中对传感器进行现场测试。这项研究将受益于工程师和流行病学家的合作，以生成一个能够在流行病学研究中使用的UFP的个人传感器。为了实现研究目标，开发的传感器将在现场验证当前的非个人，金标准仪器。在验证传感器之后，将在当前正在进行的流行病学研究的背景下进行个人传感器的现场测试，即辛辛那提抗idling运动（CAIC）研究。参加CAIC的儿童参加了四所参加的辛辛那提公立学校之一，而附近的道路或校车也有不同的陷阱。此外，CAIC参与者是哮喘的，并且已经完成了初步的健康评估。目前，通过使用学校和社区环境空气监测，在CAIC研究中评估了陷阱的暴露。因此，CAIC研究非常适合评估个人监测的好处，并确定在城市哮喘儿童中发达的传感器的可接受性和可用性。现场测试的结果将提供反馈，以修改传感器以准备在流行病学研究中广泛使用。 公共卫生相关性：关于交通相关空气污染（TRAP）对人类健康的影响的流行病学研究通常受到替代，环境或建模暴露的限制。为了解决当前表征暴露的局限性，具有高时空分辨率的个人且可穿戴的传感器，在实验室环境中已经开发并验证了对超细颗粒（UFP）的暴露。该应用程序的目的是验证该领域中高度创新的传感器，并在正在进行的学校和社区陷阱暴露的流行病学研究中对传感器进行现场测试。