Field Validation of a Personal Sensor for Ultrafine PM in Asthmatic Children

哮喘儿童超细颗粒物个人传感器的现场验证

• 批准号: 8177520
• 负责人: Patrick H Ryan
• 金额: $ 46.36万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-16 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8177520
• 关键词: Activities of Daily Living; Address; Air Pollution; Area; Asthma; Caliber; Caregivers; Characteristics; Child; Childhood; Childhood Asthma; Collaborations; Communities; Data; Detection; Engineering; Enrollment; Environment; Environmental Epidemiology; Epidemiologic Studies; Epidemiologist; Exposure to; Feedback; Funding; Gold; Health; Heart Diseases; Home environment; Human; Human Resources; Laboratories; Lung diseases; Measurement; Measures; Minority; Modeling; Modification; Monitor; Morbidity - disease rate; Nanotechnology; National Institute of Environmental Health Sciences; Occupational; Participant; Particulate; Particulate Matter; Performance; Physical activity; Population; Preparation; Process; Resolution; Respiratory physiology; Sampling; Scanning; School-Age Population; Schools; Side; Site; Son; Source; Symptoms; Testing; Time; Ultrafine; Urban Population; Validation; air monitoring; base; cohort; field study; inner city; innovation; instrument; nervous system disorder; particle; respiratory; satisfaction; sensor; spatiotemporal; trafficking; ultrafine particle; usability

DESCRIPTION (provided by applicant): Epidemiologic studies of the impact of traffic-related air pollution (TRAP) on human health are frequently limited by the use of surrogate, ambient, or modeled exposure. The need for personal monitoring is evident in susceptible subpopulations, particularly children, who spend significant time at schools and in vehicles, in addition to their homes. Further, children may have high levels of physical activity and be in close proximity to particulate sources that result in higher levels of exposure than those recorded at stationary sampling sites. In order to address current limitations in characterizing exposure, a personal and wearable sensor capable of measuring, with high spatiotemporal resolution, exposure to ultrafine particles (UFP) has been developed and validated in laboratory settings. Though the personal sensor was developed to be sufficiently small, rugged, and straightforward to allow its widespread use in epidemiologic studies, it has not been validated outside the laboratory or utilized in the field. Therefore, the objectives of this application are to validate this highly innovative sensor in the field and conduct a field test of the sensor in an ongoing epidemiologic study of TRAP exposure at schools and communities. This study will benefit from the collaboration of engineers and epidemiologists to produce a personal sensor for UFP capable of being utilized in epidemiologic studies. In order to achieve the study objectives, the developed sensor will be validated in the field against current, non- personal, gold-standard instruments. Following the validation of the sensor, a field test of the personal sensor will be conducted within the context of a currently ongoing epidemiologic study, the Cincinnati Anti-Idling Campaign (CAIC) study. Children enrolled in the CAIC attend one of four participating Cincinnati Public Schools with varying exposure to TRAP from nearby roads or school buses. In addition, CAIC participants are asthmatic and have completed an initial health assessment. Exposure to TRAP is currently assessed in the CAIC study through the use of school and community ambient air monitoring. Thus, the CAIC study is ideal to assess the benefit of personal monitoring and to determine the acceptability and usability of the developed sensor in a population of inner-city asthmatic children. The results of the field test will provide feedback in order to modify the sensor in preparation for wide-spread use in epidemiologic studies. PUBLIC HEALTH RELEVANCE: Epidemiologic studies of the impact of traffic-related air pollution (TRAP) on human health are frequently limited by the use of surrogate, ambient, or modeled exposure. In order to address current limitations in characterizing exposure, a personal and wearable sensor capable of measuring, with high spatiotemporal resolution, exposure to ultrafine particles (UFP) has been developed and validated in laboratory settings. The objectives of this application are to validate this highly innovative sensor in the field and conduct a field test of the sensor in an ongoing epidemiologic study of TRAP exposure at schools and communities.

描述（由申请人提供）：交通相关空气污染（TRAP）对人体健康影响的流行病学研究经常受到使用替代物、环境或模拟暴露的限制。对易感亚群，特别是儿童进行个人监测的必要性是显而易见的，因为他们除了在家中之外，还在学校和车辆中花费大量时间。此外，儿童可能有大量的体力活动，并且非常接近颗粒源，导致接触水平高于固定采样点记录的水平。为了解决目前在表征暴露方面的局限性，已经开发了一种能够以高时空分辨率测量超细颗粒（UFP）暴露的个人和可穿戴传感器，并在实验室环境中进行了验证。虽然个人传感器被开发成足够小、坚固和简单，以允许其在流行病学研究中广泛使用，但它尚未在实验室外进行验证或在现场使用。因此，本申请的目的是在现场验证这种高度创新的传感器，并在学校和社区正在进行的TRAP暴露流行病学研究中对传感器进行现场测试。这项研究将受益于工程师和流行病学家的合作，以生产能够用于流行病学研究的个人传感器。为了实现研究目标，开发的传感器将在现场与当前的非个人黄金标准仪器进行验证。传感器确认后，将在当前正在进行的流行病学研究（辛辛那提反怠速运动（CAIC）研究）的背景下对个人传感器进行现场测试。在CAIC注册的儿童就读于四所参与的辛辛那提公立学校之一，这些学校从附近的道路或校车上接触到不同的TRAP。此外，CAIC参与者患有哮喘，并已完成初步健康评估。CAIC研究目前通过使用学校和社区环境空气监测来评估TRAP的暴露情况。因此，CAIC研究是理想的，以评估个人监测的好处，并确定可接受性和可用性的开发传感器在人口的市中心哮喘儿童。现场测试的结果将提供反馈，以便修改传感器，为流行病学研究中的广泛使用做准备。 公共卫生关系：交通相关空气污染（TRAP）对人体健康影响的流行病学研究经常受到使用替代物、环境或模型暴露的限制。为了解决目前在表征暴露方面的局限性，已经开发了一种能够以高时空分辨率测量超细颗粒（UFP）暴露的个人和可穿戴传感器，并在实验室环境中进行了验证。本申请的目的是在现场验证这种高度创新的传感器，并在学校和社区正在进行的TRAP暴露流行病学研究中对传感器进行现场测试。