Moffitt Postdoctoral Training Program in Molecular & Genetic Epidemiology

描述（由申请人提供）：我们建议在H开发，实施和评估一个新的教育和职业发展计划。李莫菲特癌症中心和研究所在坦帕，佛罗里达。该计划将提供一个专门的课程，以准备未来的学术研究人员在观察分子和遗传流行病学中整合最新技术和全方位的结果（从风险到生存）。每年将招募两名具有流行病学，生物统计学，医学或相关学科高级学位的博士后研究员，在癌症预防和控制这一专业领域进行为期2-3年的培训计划，该领域仍然缺乏合格的研究人员。研究员将参加多学科的培训经验，其中包括分子流行病学，临床肿瘤学，癌症生物学的核心课程，加上应用方法的特别研讨会。为这次培训开发的研讨会将包括对涉及高通量先进技术和方法的应用的调查，如蛋白质组学、全基因组关联研究、纳米技术、基因表达谱和数学肿瘤学，这些技术和方法正在引领筛查、风险评估、生物监测和基于个体的诊断和治疗，即个性化医疗的发展。除了分子流行病学的专业课程外，还将为每个学员制定一个量身定制的计划，该计划将在至少两名来自不同学科的既定研究人员的指导下，将正式课程工作和分子，基础和临床研究的实践经验相结合。除了大量的大型，精心设计的分子和遗传流行病学研究，在莫菲特培训的一个独特的资产是生活方式，临床和结果数据和生物标本的可用性收集了成千上万的筛选和癌症患者作为莫菲特的全面癌症护理研究计划的一部分。这些资源为学员提供了在个性化癌症护理研究中应用研究设计和技术进步的机会。每个研究员将被要求在分子或遗传流行病学领域定义一个研究课题，并编写和捍卫一个真实的或模拟的研究资助或职业发展奖申请。由专门的教师和内部和外部咨询委员会对该计划进行持续监测和监督，将确保成功招募来自多个学科和背景的合格候选人，以及为癌症研究人员在快速变化，高技术，跨学科研究环境中的职业生涯做好准备的培训经验。

DESCRIPTION (provided by applicant): We propose to develop, implement and evaluate a new education and career development program at the H. Lee Moffitt Cancer Center and Research Institute in Tampa, Florida. The program will provide a specialized curriculum to prepare future academic researchers to integrate the latest technologies and full spectrum of outcomes (from risk to survival) in observational molecular and genetic epidemiology. Two postdoctoral fellows per year with advanced degrees in epidemiology, biostatistics, medicine or a related discipline will be recruited for a 2-3 year training program within this specialty area in cancer prevention and control that continues to see a shortage of qualified investigators. Fellows will participate in a multidisciplinary training experience that includes a core curriculum in molecular epidemiology, clinical oncology, cancer biology, plus special workshops in applied methodologies. Seminars developed for this training will include a survey of applications involving high-throughput advanced technologies and methods such as proteomics, genome-wide association studies, nanotechnology, gene expression profiling, and mathematical oncology that are leading the way to advances in screening, risk assessment, biomonitoring, and individual-based diagnosis and treatment, i.e. personalized medicine. In addition to the specialized curriculum in molecular epidemiology, a tailored program will be developed for each trainee that combines formal course work and hands-on experience in molecular, basic and clinical research under the guidance of at least two established investigators from different disciplines. In addition to a wide array of large, well-designed molecular and genetic epidemiologic studies, a unique asset for training at Moffitt is the availability of lifestyle, clinical and outcome data and biospecimens collected on many thousands of screening and cancer patients as part of Moffitt's Total Cancer Care research program. These resources afford an opportunity for trainees to apply study design and technology advances in personalized cancer care research. Each fellow will be required to define a research topic in the area of molecular or genetic epidemiology and write and defend a real or mock research grant or career development award application. Ongoing monitoring and over sight of the program by a dedicated faculty, and internal and external advisory boards, will ensure success in recruiting qualified candidates from multiple disciplines and backgrounds, and a training experience that prepares cancer researchers for careers in a rapidly changing, highly technical, interdisciplinary research environment.