NINDS Research Education Programs for Residents and Fellows in Neurology and Neur

描述(由申请者提供)：项目描述：神经学学术项目的住院医师是年轻内科医生发展成为神经科学临床科学家的理想环境。每个子专业的资深教师都可以帮助住院医生开始基础科学、临床或转化性研究计划，帮助他们开始成功的临床实践，提供平衡研究和临床工作的模式，并指导他们出版和获得研究资金。然而，研究和临床培训的资金都很紧张，以前没有资金支持住院医师期间用于研究培训的时间。这种R25机制将满足对优秀住院医生的需求，他们将成为神经学研究的未来领导者。然而，也需要培养未来的导师，他们将在未来几年成为日益多样化的常驻申请者的杰出榜样和导师。我们的目标是为临床医生-科学家提供最高水平的研究技能、研究道德、数据分析和报告以及职业发展方面的教育，他们将成功地为他们的指导(以及后来的独立)生产性研究获得资金。我们的另一个目标是让我们的高级导师--他们是临床科学家，在培训年轻的内科研究人员方面拥有丰富的经验--指导更多拥有成功研究项目的初级导师，他们将能够在未来几年实现我们的主要目标。我们的初级导师是一群种族和民族多元化的男性和女性，他们将成为本计划中不同的当前和未来居民和研究员的杰出榜样。为了实现这些目标，每个参与该计划的住院医师都将与一名高级导师和初级研究导师配对，后者将帮助住院医师为其项目获取必要的技能，并帮助指导住院医师在其中一名导师和/或他们的亲密同事的实验室中完成成功的研究项目的所有步骤，进行富有成效的、受资助的研究。我们将跟踪每个住院医生在住院后至少10年内在指导研究(K08或K23奖项)、独立研究资助和出版物方面的成功情况。 公共卫生相关性：近年来，神经疾病的治疗取得了巨大进展，但许多最常见和最令人衰弱的神经疾病(如中风、痴呆症、多发性硬化症、癫痫、原发脑瘤)的治疗选择仍然非常有限。改进这些疾病的预防或治疗的研究将需要具有创造性和敬业精神的内科科学家，他们了解未得到满足的需求，并将开发和评估新干预措施的有效性。这项计划将帮助神经科住院医生发展成为这样的临床医生-科学家，并将使他们开始一项成功的研究计划，这将导致神经疾病的新干预措施。

DESCRIPTION (provided by applicant): Project Description: Residency in an academic neurology program is the ideal setting for a young physician to develop into a clinician-scientist in the neurosciences. Senior faculty in every subspecialty are available to assist residents in starting a basic science, clinical, or translational research program, to help them start a successful clinical practice, to provide a model in balancing the research and clinical work, and to mentor them in publishing and obtaining research funding. However, funds for both research and clinical training are tight, and there previously had been no financial support for time devoted to research training during residency. This R25 mechanism will fill this need for outstanding residents who will be the future leaders in neurology research. However, there is also a need for developing future mentors, who will be exceptional role models and mentors for the increasingly diverse resident applicants in the coming years. Our goal is provide the highest level of education in research skills, research ethics, data analysis and reporting, and career development for clinician-scientists, who will be successful in obtaining funding for their mentored (and later, independent) productive research. Another goal is for our senior mentors, who are clinician scientists with extensive experience in training young physician investigators, to mentor more junior mentors with successful research programs who will be able to carry out our primary goal in future years. Our junior mentors are a racially and ethnically diverse group of men and women who will be exceptional role models for the diverse set of current and future residents and fellows in this program. To meet these goals, each resident who participates in this program will be paired with both a senior mentor and junior research mentor, who will assist the resident in obtaining necessary skills for his or her project and help guide the resident through all steps of a successful research project in the laboratory of one of the mentors and/or their close colleagues with productive, funded research. We will track success of each resident with respect to awards of funding for mentored research (K08 or K23 awards), independent research grants, and publications, for a minimum of 10 years after residency. Public Health Relevance: There has been tremendous progress over recent years in treatment of neurological disease, but the treatment options for many of the most common and debilitating neurological diseases (such as stroke, dementia, multiple sclerosis, epilepsy, primary brain tumors) remain very limited. Research to improve prevention or treatment of these diseases will require creative and dedicated physician-scientists who understand the unmet needs and will develop and assess the effectiveness of new interventions. This program will help neurology residents develop into such clinician-scientists, and will get them started on a successful research program that will lead to novel interventions for neurological diseases.