Non-Invasive Image-Guided HIFU for Breast Cancer Therapy

描述(申请人提供)：MRI的改进现在使开发和实施范式转换、在线模型预测控制系统成为可能，从而使热疗治疗更加准确和临床实用。我们的目标是开发并在一种新型的、完全非侵入性的、MRI引导的相控阵HIFU加热系统中使用这种控制器，该系统专为乳腺肿瘤的热疗而设计。这是一个重要的临床地点，有大量的患者，目前的治疗可以显著改善。建议的系统有几项独特的创新，包括：具有集成MRI接收器线圈的新型特定于乳房的HIFU相控阵加热系统；最佳、自适应、模型预测控制系统；先进的MR温度测量技术；基于创新的MR组织特性和灌注测量的患者特定治疗计划；以及用于临床医生治疗监测和监督控制的交互式3D显示。这些创新将通过犹他大学(UU)、西门子医疗解决方案(SMS)和图像引导治疗(IGT)的跨学科科学家、工程师和临床医生之间的密切学术/行业合作实现。这一新的集成系统及其创新的改进不仅将显著提高乳腺肿瘤热疗的技术水平，而且将适用于所有临床地点。 公共卫生相关性：这项研究将开发和测试一种改进的、完全非侵入性的乳腺癌高温热疗系统。该系统将包括一个特别设计的超声波、相控阵设计的加热喷头，它与磁共振成像系统相耦合。他们将共同加热肿瘤并非侵入性地测量其温度，加热系统和成像系统都在一种新颖的模型预测控制系统的指导下，该系统将在提供有效、实用的治疗的同时确保患者的安全。

DESCRIPTION (provided by applicant): Improvements in MRI have now made it possible to develop and implement paradigm-shifting, on-line model- predictive control systems to make thermal therapy treatments more accurate and clinically practical. Our goal is to develop and use such a controller in a novel, completely non-invasive, MRI-guided, phased array HIFU heating system, designed specifically for thermal therapy of breast tumors. This is an important clinical site with a large population of patients for whom current treatments can be significantly improved. The proposed system has several unique innovations including: a new, breast-specific, HIFU phased array heating system with integrated MRI receiver coils; an optimal, adaptive, model-predictive control system; advanced MR temperature measurement techniques; patient-specific treatment planning based on innovative MR tissue- property and perfusion measurements; and interactive 3D displays for clinician treatment monitoring and supervisory control. These innovations will be achieved through the close academic/industrial partnership between interdisciplinary scientists, engineers and clinicians at the University of Utah (UU), Siemens Medical Solutions (SMS) and Image Guided Therapy (IGT). This novel integrated system and its innovative improvements will not only significantly advance the state of the art of thermal therapies for breast tumors, but for all clinical sites. PUBLIC HEALTH RELEVANCE: This study will develop and test an improved, completely non-invasive system for breast cancer thermal therapy at high temperatures. The system will consist of a specially designed ultrasonic, phased array designed heating applicator that is coupled with an MRI imaging system. Together, they will heat the tumor and measure its temperature non-invasively, with both the heating system and the imaging system under guided by a novel, model predictive control system that will keep the patient safe while delivering an effective, practical treatment.