Dynamic Composite Multi-Gradient Systems for Advanced MRI

用于高级 MRI 的动态复合多梯度系统

• 批准号: 8475445
• 负责人: DENNIS L PARKER
• 金额: $ 43.38万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8475445
• 关键词: Address; Anatomy; Auditory; Brain; Brain imaging; Cavia; Cholesteatoma; Clinical; Clinical Research; Cochlea; Dependence; Detection; Diagnosis; Diagnostic; Diffusion weighted imaging; Discrimination; Disease; Disease Management; Ear; Echo-Planar Imaging; Endolymphatic Hydrops; Equilibrium; Frequencies; Growth; Head; Hemorrhage; Human Volunteers; Image; Imagery; Inflammation; Inflammatory; Labyrinth; Lesion; Liquid substance; Magnetic Resonance Imaging; Measures; Meniere' s Disease; Middle Ear Neoplasm; Monitor; Nerve; Nerve Tissue; Neurilemmoma; Neuritis; Noise; Pathology; Performance; Physiologic pulse; Positioning Attribute; Process; Protocols documentation; Radio; Research Infrastructure; Residual state; Resolution; Sensorineural Hearing Loss; Serous; Shapes; Signal Transduction; Source; Specific qualifier value; Speed; Structure; System; Techniques; Technology; Testing; Time; Tissues; Unnecessary Surgery; Work; abstracting; adenoma; advanced system; body system; effusion; flexibility; human subject; improved; middle ear; mucoid; novel; operation; public health relevance; research study

DESCRIPTION (provided by applicant): Dynamic composite multi-gradient systems for advanced MRI Abstract: This project will use a novel composite gradient system to test that images of the fine structure of inner and middle ear anatomy obtained with magnetic resonance imaging (MRI) and, ultimately, the diagnosis of inner and middle ear pathology can be greatly improved by gradient performance that is increased over the conventional typical amplitudes of 40 to 45 mT/m and slew rates of 200T/m/s. The gradient system will combine the system body gradients simultaneously with an insert head gradient to achieve gradient performance that is nearly a factor of 3 greater in speed and amplitude than the body gradients alone. Because pathologies of the inner ear require very high spatial resolution that is often beyond the capabilities of conventional MRI scanners, the experiments proposed in this study to detect these pathologies are ideal tests for the improved performance of composite gradients. By determining the cause of sudden sensorineural hearing loss the appropriate treatment could be specified early in the disease management. An objective test for endolymphatic hydrops would allow improved diagnosis and monitoring of therapy in Meniere's and related disorders. By accurately discriminating between residual cholesteatoma and other non-tumor tissues of the middle ear, this project could eliminate many unnecessary surgeries. To the best of our knowledge, this is the first work to systematically evaluate the value of very high gradient performance in diagnostic studies of the middle and inner ear. In this study, the body and local gradients will be used simultaneously with equivalent waveform shapes and timing. This work will advance the technology available for clinical MRI by demonstrating: 1) the flexibility and potential performance improvement of composite gradient systems over conventional single gradient systems and 2) that no image quality is lost when using only the body gradients with the insert gradients in position. Thus, the insert gradients can be kept in position for clinical whole brain studies and be available for use on sequences that require increased gradient performance. These observations have never before been demonstrated.

描述（申请人提供）：用于高级MRI的动态复合多梯度系统摘要：该项目将使用一种新型复合梯度系统来测试通过磁共振成像（MRI）获得内耳和中耳解剖结构的精细结构的图像，并最终，通过在常规的典型振幅上增加梯度性能40至45 mT/m，转换速率为200 T/m/s。梯度系统将联合收割机同时将系统主体梯度与插入头梯度相结合，以实现梯度性能，其速度和幅度几乎是单独主体梯度的3倍。由于内耳的病理需要非常高的空间分辨率，这通常超出了传统MRI扫描仪的能力，因此本研究中提出的检测这些病理的实验是用于改善复合梯度性能的理想测试。通过确定突发性感音神经性听力损失的原因，可以在疾病管理的早期指定适当的治疗。对内淋巴积水的客观检测将有助于改善梅尼埃病和相关疾病的诊断和治疗监测。通过准确区分残留的中耳乳突瘤和其他非肿瘤组织，该项目可以消除许多不必要的手术。 据我们所知，这是第一项系统评估极高梯度性能在中耳和内耳诊断研究中的价值的工作。在本研究中，将同时使用具有等效波形形状和时序的身体和局部梯度。这项工作将通过证明：1）复合梯度系统相对于传统单一梯度系统的灵活性和潜在性能改进以及2）当仅使用身体梯度和插入梯度时，不会损失图像质量，从而推进临床MRI可用的技术。因此，插入梯度可以保持在临床全脑研究的适当位置，并可用于需要增加梯度性能的序列。这些观察结果以前从未被证明过。

项目成果

New head gradient coil design and construction techniques.

• DOI: 10.1002/jmri.24254
• 发表时间: 2014-05
• 期刊: JOURNAL OF MAGNETIC RESONANCE IMAGING
• 影响因子: 4.4
• 作者: Handler, William B.;Harris, Chad T.;Scholl, Timothy J.;Parker, Dennis L.;Goodrich, K. Craig;Dalrymple, Brian;Van Sass, Frank;Chronik, Blaine A.
• 通讯作者: Chronik, Blaine A.