Faculty Recruitment in Aging and Metabolism Research

描述(由申请者提供)：罗切斯特大学拥有一支充满活力的、跨学科的科学家团队，致力于代谢调节和衰老的交叉项目。我们已经确定了几个能力领域，这些领域将从战略上加强这一群体。能够利用先进的基因组资源对影响衰老、应激信号和新陈代谢的基因进行无偏见的遗传筛选就是其中之一。此外，增加一个拥有衰老专业知识的线虫实验室将极大地增强罗切斯特老龄化研究的生物医学影响。这项申请的目的是为了获得资金，以招聘一名助理教授，该助理教授将补充该大学已有的具有国际竞争力的老龄化研究小组。我们已经确定安德鲁·萨缪尔森博士是这一职位的优秀候选人，他目前是哈佛大学加里·鲁夫昆博士实验室的博士后研究员。萨缪尔森博士访问了该大学，并与教职员工讨论了共同的研究兴趣。认识到罗切斯特大学卓有成效的合作以及科学和学术发展的前景，他承诺接受生物医学遗传学系的助理教授职位，如果通过这项申请获得资金的话。在这里，我们描述萨缪尔森博士的研究计划，以及它如何与大学现有的老龄化研究工作相适应。此外，我们还讨论了萨缪尔森博士将如何从罗切斯特大学和生物医学遗传学系的科学环境和指导文化中受益。2009年《美国复苏和再投资法案》的目的是创造就业机会，并为追求改善美国公民生活时间和质量的科学提供资金。这项申请建议在罗切斯特大学医学中心(URMC)建立一个在遗传学、细胞生物学和衰老生理学方面拥有世界级专业知识的研究团队。萨缪尔森博士领导的研究团队最初将由至少四人组成，他们都受雇于新创造的工作岗位。 公共卫生相关性：该提案支持的多学科研究计划将促进在分子、细胞和生物体水平上对胰岛素功能的透彻了解。知识的预期增长将使多个科学学科受益，从基础衰老研究到胰岛素抵抗和代谢综合征的生物医学研究。

DESCRIPTION (provided by applicant): The University of Rochester hosts a vibrant, interdisciplinary team of scientists working on projects at the intersection of metabolic regulation and aging. We have identified several areas of competence that would strategically strengthen this group. The ability to use advanced genomic resources to conduct unbiased genetic screens for genes affecting aging, stress signaling and metabolism is one of these areas. Furthermore, the addition of a C. elegans lab with expertise in aging would greatly potentiate the biomedical impact of aging research in Rochester. The purpose of this application is to secure funds for the recruitment of an assistant professor who would complement the internationally competitive aging research group already at the University. We have identified Dr. Andrew Samuelson, currently a postdoctoral fellow in the laboratory of Dr. Gary Ruvkun at Harvard/MGH, as an excellent candidate for this position. Dr. Samuelson has visited the University and discussed common research interests with the faculty. Recognizing the perspectives for fruitful collaborations, and for scientific and academic growth at the University of Rochester, he is committed to accept an Assistant Professor position in the Department of Biomedical Genetics, should funds through this application become available. Herein, we describe Dr. Samuelson's research plan and how it fits into the context of the existing aging research efforts at the University. Furthermore, we discuss how Dr. Samuelson would benefit from the scientific environment and mentoring culture at the University of Rochester and in the Department of Biomedical Genetics. The purpose of the American Recovery and Reinvestment Act of 2009 is to create jobs, and to fund science in pursuit of improving the length and the quality of the lives of U.S. citizens. This application proposes a research team with world-class expertise in the genetics, cell biology and physiology of aging to be established at the University of Rochester Medical Center (URMC). The research team lead by Dr. Samuelson would initially consist of at least four individuals, all employed in newly created jobs. PUBLIC HEALTH RELEVANCE: The multidisciplinary research program supported by this proposal would promote a thorough understanding of insulin function at the molecular, cell and organism level. The expected gain of knowledge would benefit multiple scientific disciplines ranging from basic aging research to biomedical studies of insulin resistance and metabolic syndrome.