Faculty Recruitment in Aging and Metabolism Research

描述（由申请人提供）：罗彻斯特大学拥有一支充满活力的跨学科科学家团队，他们致力于代谢调节和衰老交叉的项目。我们已经确定了几个能够在战略上加强这个团队的能力领域。利用先进的基因组资源对影响衰老、应激信号和代谢的基因进行无偏遗传筛选的能力就是这些领域之一。此外，拥有衰老专业知识的秀丽隐杆线虫实验室的增加将极大地增强罗切斯特衰老研究的生物医学影响。本申请的目的是为招募一名助理教授提供资金，以补充该大学已有的具有国际竞争力的老龄化研究小组。Andrew Samuelson博士目前是哈佛大学/MGH Gary Ruvkun博士实验室的博士后，我们认为他是该职位的优秀候选人。萨缪尔森博士访问了该大学，并与教师讨论了共同的研究兴趣。认识到富有成效的合作前景，以及罗切斯特大学的科学和学术发展，他承诺接受生物医学遗传学系的助理教授职位，如果通过该申请获得资金。在这里，我们描述了萨缪尔森博士的研究计划，以及它如何适应大学现有的老龄化研究工作的背景。此外，我们还讨论了萨缪尔森博士将如何从罗切斯特大学和生物医学遗传学系的科学环境和指导文化中受益。2009年《美国复苏与再投资法案》的目的是创造就业机会，并资助旨在延长美国公民寿命和提高其生活质量的科学研究。这项申请提议在罗切斯特大学医学中心（URMC）建立一个在遗传学、细胞生物学和衰老生理学方面具有世界一流专业知识的研究团队。萨缪尔森博士领导的研究小组最初将至少由四个人组成，所有人都在新创造的工作岗位上工作。

DESCRIPTION (provided by applicant): The University of Rochester hosts a vibrant, interdisciplinary team of scientists working on projects at the intersection of metabolic regulation and aging. We have identified several areas of competence that would strategically strengthen this group. The ability to use advanced genomic resources to conduct unbiased genetic screens for genes affecting aging, stress signaling and metabolism is one of these areas. Furthermore, the addition of a C. elegans lab with expertise in aging would greatly potentiate the biomedical impact of aging research in Rochester. The purpose of this application is to secure funds for the recruitment of an assistant professor who would complement the internationally competitive aging research group already at the University. We have identified Dr. Andrew Samuelson, currently a postdoctoral fellow in the laboratory of Dr. Gary Ruvkun at Harvard/MGH, as an excellent candidate for this position. Dr. Samuelson has visited the University and discussed common research interests with the faculty. Recognizing the perspectives for fruitful collaborations, and for scientific and academic growth at the University of Rochester, he is committed to accept an Assistant Professor position in the Department of Biomedical Genetics, should funds through this application become available. Herein, we describe Dr. Samuelson's research plan and how it fits into the context of the existing aging research efforts at the University. Furthermore, we discuss how Dr. Samuelson would benefit from the scientific environment and mentoring culture at the University of Rochester and in the Department of Biomedical Genetics. The purpose of the American Recovery and Reinvestment Act of 2009 is to create jobs, and to fund science in pursuit of improving the length and the quality of the lives of U.S. citizens. This application proposes a research team with world-class expertise in the genetics, cell biology and physiology of aging to be established at the University of Rochester Medical Center (URMC). The research team lead by Dr. Samuelson would initially consist of at least four individuals, all employed in newly created jobs. PUBLIC HEALTH RELEVANCE: The multidisciplinary research program supported by this proposal would promote a thorough understanding of insulin function at the molecular, cell and organism level. The expected gain of knowledge would benefit multiple scientific disciplines ranging from basic aging research to biomedical studies of insulin resistance and metabolic syndrome.