Combined cognitive remediation and behavioral intervention for treatment of ADHD

描述(由申请人提供)：这笔赠款的总体目标是开发一种新的联合治疗方案，将改善ADHD儿童的功能。具体地说，我们建议开发一种有前景的计算机化认知训练计划Cogmed的新组合，该计划针对ADHD儿童的工作记忆缺陷，并结合行为父母培训，这是一种成熟的、基于证据的ADHD干预措施。特别是，我们建议这种联合干预，CogBPT，在本质上是互补的，因为这两种干预方式针对ADHD儿童不同的病理性领域(Cogmed可能潜在地改变与ADHD相关的较长期的潜在神经缺陷，而BPT解决常见的共生并存[奇怪]和损害[亲子关系])。或者，Cogmed和BPT的结合在本质上可能是互补和增强的，因为这两种干预方式不仅可能针对ADHD儿童的不同病理性领域，而且Cogmed对与ADHD相关的潜在神经缺陷的影响可能会增强BPT的影响。因此，CogBPT可能会对具有复杂临床表现的ADHD儿童的急性和长期功能产生实质性影响。因此，CogBPT可能是一种新的治疗方法，有可能广泛、具有成本效益地应用于ADHD的治疗，并有可能从ADHD中恢复。ADHD是一种常见的、慢性的和损害儿童神经发育的障碍。 公共卫生相关性：该项目旨在为患有注意力缺陷/多动障碍(ADHD)的学龄儿童开发一种新的干预组合，从而持久地减少儿童的ADHD症状和相关损害，从而防止ADHD往往贯穿一生的慢性和高度损害的过程。

DESCRIPTION (provided by applicant): The overall aim of this grant is to develop a novel combined treatment regimen that will improve functioning in children with ADHD. Specifically, we propose developing a novel combination of a promising, computerized cognitive training program, Cogmed, targeting working memory deficits in children with ADHD in combination with behavioral parent training, a well-established, evidence-based intervention for ADHD. In particular, we propose that this combined intervention, CogBPT, could be complementary in nature in that these two intervention modalities target distinct pathological domains in children with ADHD (Cogmed may potentially alter longer-term underlying neurological deficits associated with ADHD while BPT addresses common co-occurring comorbidities [ODD] and impairments [parent-child relationships]). Alternatively, combining Cogmed with BPT could be complementary and augmentive in nature in that not only may these two intervention modalities target distinct pathological domains in children with ADHD, but that Cogmed's impact on underlying neurological deficits associated with ADHD may enhance the impact of BPT. Thus, CogBPT could potentially lead to substantial effects in both acute and longer-term functioning for children with ADHD with complex clinical presentations. As such, CogBPT may be a new treatment approach that has the potential for widespread, cost-effective application for the treatment of and potential recovery from ADHD, a common, chronic and impairing childhood neurodevelopmental disorder. PUBLIC HEALTH RELEVANCE: This project is designed to develop a novel Combination of interventions for school age children with Attention Deficit/Hyperactivity Disorder (ADHD) that will result in enduring reductions of ADHD symptoms and associated impairments in children, and thus prevent the chronic and highly impairing course that ADHD oftentimes takes throughout the lifespan.