Combined cognitive remediation and behavioral intervention for treatment of ADHD

认知矫正与行为干预相结合治疗多动症

• 批准号: 8097516
• 负责人: Anil Chacko
• 金额: $ 23.02万
• 依托单位: QUEENS COLLEGE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8097516
• 关键词: Academic achievement; Acute; Address; Adherence; Affect; Aftercare; Animals; Applications Grants; Area; Attention; Attention deficit hyperactivity disorder; Behavior; Behavior Therapy; Behavioral; Behavioral Symptoms; Child; Childhood; Chronic; Clinical; Clinical Trials; Cognitive; Cognitive Therapy; Cognitive remediation; Combined Modality Therapy; Comorbidity; Complex; Comprehensive Health Care; Consumer Satisfaction; Data; Development; Diagnosis; Disease; Dose; Evidence based intervention; Goals; Grant; Impairment; Intervention; Investigation; Lead; Literature; Longevity; Maintenance; Measures; Mediating; Memory; Memory impairment; Modality; Modeling; Nature; Neurocognitive; Neurocognitive Deficit; Neurodevelopmental Disorder; Neurologic; Neuropsychological Tests; Oppositional Defiant Disorder; Outcome; Outcome Study; Parent-Child Relations; Parenting behavior; Parents; Participant; Pattern; Pharmaceutical Preparations; Physiological; Process; Psychosocial Influences; Publishing; Randomized Clinical Trials; Recovery; Regimen; Relative (related person); Reporting; Sampling; School-Age Population; Short-Term Memory; Stress; Sum; Symptoms; Techniques; Testing; Time; Training; Training Programs; Treatment Protocols; United States National Institutes of Health; Youth; active method; base; cognitive training; computerized; cost effective; design; effective intervention; experience; follow-up; improved; improved functioning; neural growth; novel; peer; prevent; programs; psychoeducational; psychopharmacologic; psychosocial; public health relevance; relating to nervous system; remediation; teacher; treatment effect; treatment response

DESCRIPTION (provided by applicant): The overall aim of this grant is to develop a novel combined treatment regimen that will improve functioning in children with ADHD. Specifically, we propose developing a novel combination of a promising, computerized cognitive training program, Cogmed, targeting working memory deficits in children with ADHD in combination with behavioral parent training, a well-established, evidence-based intervention for ADHD. In particular, we propose that this combined intervention, CogBPT, could be complementary in nature in that these two intervention modalities target distinct pathological domains in children with ADHD (Cogmed may potentially alter longer-term underlying neurological deficits associated with ADHD while BPT addresses common co-occurring comorbidities [ODD] and impairments [parent-child relationships]). Alternatively, combining Cogmed with BPT could be complementary and augmentive in nature in that not only may these two intervention modalities target distinct pathological domains in children with ADHD, but that Cogmed's impact on underlying neurological deficits associated with ADHD may enhance the impact of BPT. Thus, CogBPT could potentially lead to substantial effects in both acute and longer-term functioning for children with ADHD with complex clinical presentations. As such, CogBPT may be a new treatment approach that has the potential for widespread, cost-effective application for the treatment of and potential recovery from ADHD, a common, chronic and impairing childhood neurodevelopmental disorder. PUBLIC HEALTH RELEVANCE: This project is designed to develop a novel Combination of interventions for school age children with Attention Deficit/Hyperactivity Disorder (ADHD) that will result in enduring reductions of ADHD symptoms and associated impairments in children, and thus prevent the chronic and highly impairing course that ADHD oftentimes takes throughout the lifespan.

描述（由申请人提供）：这笔赠款的总体目标是开发一种新颖的联合治疗方案，以改善多动症儿童的功能。具体来说，我们建议开发一种新颖的组合，将一种有前景的计算机化认知训练计划 Cogmed 结合起来，针对 ADHD 儿童的工作记忆缺陷，并结合行为父母培训，这是一种行之有效的、基于证据的 ADHD 干预措施。特别是，我们建议这种联合干预措施 CogBPT 在本质上可以是互补的，因为这两种干预方式针对的是 ADHD 儿童的不同病理领域（Cogmed 可能会改变与 ADHD 相关的长期潜在神经功能缺陷，而 BPT 则可以解决常见的共存并发症 [ODD] 和损伤 [亲子关系]）。或者，将 Cogmed 与 BPT 相结合本质上可以是互补和增强的，因为这两种干预方式不仅可以针对 ADHD 儿童的不同病理领域，而且 Cogmed 对与 ADHD 相关的潜在神经缺陷的影响可能会增强 BPT 的影响。因此，CogBPT 可能会对临床表现复杂的 ADHD 儿童的急性和长期功能产生重大影响。因此，CogBPT 可能是一种新的治疗方法，具有广泛、经济高效的应用潜力，可用于治疗 ADHD（一种常见的、慢性的、受损的儿童神经发育障碍）并有可能从中恢复。 公共健康相关性：该项目旨在为患有注意力缺陷/多动症 (ADHD) 的学龄儿童开发一种新颖的干预措施组合，这将导致儿童 ADHD 症状和相关损伤的持久减少，从而防止 ADHD 在整个生命周期中经常出现的慢性和高度损伤的过程。

项目成果

Improving outcomes for youth with ADHD: a conceptual framework for combined neurocognitive and skill-based treatment approaches.

• DOI: 10.1007/s10567-014-0171-5
• 发表时间: 2014-12
• 期刊: Clinical child and family psychology review
• 影响因子: 6.9
• 作者: Chacko A;Kofler M;Jarrett M
• 通讯作者: Jarrett M

Cogmed Working Memory Training for youth with ADHD: a closer examination of efficacy utilizing evidence-based criteria.

• DOI: 10.1080/15374416.2013.787622
• 发表时间: 2013
• 期刊: Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
• 作者: Chacko A;Feirsen N;Bedard AC;Marks D;Uderman JZ;Chimiklis A
• 通讯作者: Chimiklis A

Sequenced neurocognitive and behavioral parent training for the treatment of ADHD in school-age children.

• DOI: 10.1080/09297049.2017.1282450
• 发表时间: 2018-05
• 期刊: Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
• 作者: Chacko A;Bedard AV;Marks D;Gopalan G;Feirsen N;Uderman J;Chimiklis A;Heber E;Cornwell M;Anderson L;Zwilling A;Ramon M
• 通讯作者: Ramon M

A randomized clinical trial of Cogmed Working Memory Training in school-age children with ADHD: a replication in a diverse sample using a control condition.

• DOI: 10.1111/jcpp.12146
• 发表时间: 2014-03
• 期刊: Journal of child psychology and psychiatry, and allied disciplines
• 作者: Chacko A;Bedard AC;Marks DJ;Feirsen N;Uderman JZ;Chimiklis A;Rajwan E;Cornwell M;Anderson L;Zwilling A;Ramon M
• 通讯作者: Ramon M