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A Bridge to Treatment for Out-of-Treatment Injection Heroin Users

为停止治疗的注射海洛因使用者提供治疗的桥梁

基本信息

批准号：
8081710
负责人：
Kenneth Silverman
金额：
$ 63.91万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-30 至 2013-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8081710
关键词：
AIDS prevention Abstinence Address Adherence Aftercare Baltimore Behavior Behavior Therapy Cities Cocaine Dose Drug abuse Drug usage Effectiveness Employment Enrollment Evaluation Exposure to HIV Heroin Heroin Users Injecting drug user Injection of therapeutic agent Intervention Measurable Methadone Needle-Exchange Programs Opiates Participant Patients Pharmaceutical Preparations Population Prevention approach Psychological reinforcement Randomized Recruitment Activity Refractory Research Personnel Risk Risk Behaviors Sampling Staging System Therapeutic Unemployment Urinalysis Urine Wages Work Workplace base behavior change cocaine use drug abstinence high risk methadone maintenance novel novel strategies outreach therapeutic effectiveness therapy development tool transmission process treatment adherence treatment as usual voucher

项目摘要

DESCRIPTION (provided by applicant): Injection drug use is a common mode of HIV transmission. Methadone can reduce injection heroin use and injection-related HIV risk behaviors, but most injection heroin users are difficult to engage in treatment. A randomized study is planned over 5 years to evaluate the effectiveness of the Therapeutic Workplace in promoting engagement in methadone treatment and increasing drug abstinence in unemployed, out-of- treatment, injection heroin users. The Therapeutic Workplace is a novel employment-based intervention that uses wages for work to reinforce clinically important behavior change. Workplace participants are paid to work in a supported workplace. To promote clinically important behaviors, wages are arranged contingent both on work and those behaviors. In this study, participants will be invited to attend the workplace and enroll in methadone treatment. During a workplace induction period, participants will be allowed to work and earn wages independent of whether they enroll in methadone treatment and independent of their drug use. After 4 weeks, workplace participants (N = 162) will be randomly assigned to one of three groups. All groups will be invited to attend the workplace for 26 weeks. "Methadone Contingency" participants will be required to take methadone to work, and will receive a brief pay decrease for missing a dose. Because many heroin users also use cocaine, even during methadone treatment, "Methadone and Abstinence Contingency" participants will be required to take methadone to work, and will receive a brief pay decrease for missing a methadone dose or for providing a cocaine-positive urine sample. "Usual Care" participants will be allowed to work independent of their methadone use or urinalysis results. We expect that the "Methadone Contingency" group will increase methadone adherence and decrease heroin use; and that the "Methadone and Abstinence Contingency" group will increase methadone adherence, and decrease heroin and cocaine use. Since methadone is effective at retaining patients in treatment once enrolled, we expect that once the "Methadone Contingency" engages participants in methadone treatment, the methadone will serve to maintain their participation in treatment after exposure to the Therapeutic Workplace ends. The Therapeutic Workplace could serve as a bridge to engage out-of-treatment injection heroin users into methadone treatment, and to reduce their drug use and injection-related HIV risk behaviors.

描述（由申请人提供）：注射吸毒是艾滋病毒传播的一种常见方式。美沙酮可以减少注射海洛因使用和注射相关的艾滋病危险行为，但大多数注射海洛因使用者难以进行治疗。计划进行一项为期5年的随机研究，以评估治疗工作场所在促进美沙酮治疗和增加失业、停止治疗、注射海洛因使用者戒毒方面的有效性。治疗性工作场所是一种新型的基于就业的干预措施，使用工作工资来加强临床上重要的行为改变。工作场所参与者在受支持的工作场所工作，并获得报酬。为了促进临床上重要的行为，工资是根据工作和这些行为来安排的。在这项研究中，参与者将被邀请到工作场所并参加美沙酮治疗。在工作场所的诱导期内，参与者将被允许工作和赚取工资，无论他们是否参加美沙酮治疗，也无论他们是否使用毒品。4周后，工作场所参与者（N = 162）将被随机分配到三组之一。所有团体将被邀请参加工作场所26周。“美沙酮应急”参与者将被要求服用美沙酮上班，并将因错过一剂而获得短暂的减薪。由于许多海洛因使用者也使用可卡因，即使在美沙酮治疗期间，“美沙酮和禁欲应急”参与者将被要求服用美沙酮上班，并将因错过美沙酮剂量或提供可卡因阳性尿样而获得短暂的工资减少。“精神护理”参与者将被允许工作独立于他们的美沙酮使用或尿液分析结果。我们预计，“美沙酮应急”组将增加美沙酮的坚持和减少海洛因的使用;和“美沙酮和禁欲应急”组将增加美沙酮的坚持，减少海洛因和可卡因的使用。由于美沙酮在登记后可有效地留住患者接受治疗，我们预计一旦“美沙酮应急”使参与者接受美沙酮治疗，美沙酮将有助于在治疗工作场所结束后维持他们参与治疗。治疗工作场所可以作为一个桥梁，使治疗结束后的注射海洛因使用者接受美沙酮治疗，并减少他们的药物使用和注射相关的艾滋病毒风险行为。