An Intelligent Capsule Endoscopy Video Analysis Software Platform

描述(申请人提供)：胃肠道(GI)恶性肿瘤是世界上最常见的癌症原因。世界上每年有1080万人罹患癌症，其中约330万人患有胃肠道恶性肿瘤。直到最近，通过传统的内窥镜检查，胃肠道唯一可以成像的部分是食道、胃和结肠。使用推进式小肠镜或放射成像技术等技术对小肠的初始段进行成像，但这些方法给患者带来严重的不适，成本高昂，或缺乏敏感性。胶囊内窥镜(CE)是一种正在改变胃肠道内窥镜诊断面貌的新技术。CE是胃肠道成像领域广受赞誉的突破，尤其是在小肠成像方面。然而，当前的CE视频显示/分析软件(SW)远远落后。它的局限性包括观看和翻译视频的时间很长(例如~2小时)，并且难以分析(例如可视化)结果。这些短波问题已经给患者带来了相当大的成本，迫切需要解决。为了解决这个问题，我们与我们的合作者一起，建议开发一种新的软件系统，以完全自动化视频审查过程，并实现全面和准确的疾病分析。拟议的软件系统将具有以下临床影响和意义：3/4来自CE视频的全自动和高效的疾病检测和分类；3/4全面的可视化或分析工具，以实现更准确的疾病诊断；3/4审查过程中不再遗漏GI障碍区域；3/4用于更好地被大众接受和有效的疾病预防的低成本软件系统；以及3/4模块化、可扩展和可扩展的技术。开发的专有软件模块(功能)技术可以很容易地应用于现有的诊断仪器。千禧研究集团预测，仅在美国，胶囊内窥镜市场在2009年就将产生超过1.8亿美元的收入--而2004年只有4000万美元。预测2008-2015年间的复合年增长率为35.1%。根据给出成像有限公司的数据，全球已有100多万名患者使用他们的PillCam胶囊进行了胶囊内窥镜检查。胶囊内窥镜是一个快速增长的数十亿美元的市场(预计2015年全球将达到10亿美元大关)。所提出的软件系统和技术具有巨大的商业化潜力。 公共卫生相关性：在该SBIR项目下开发的软件系统和技术将通过提供节省成本和高精度的GI肠道疾病发现和分析软件平台，为GI患者提供巨大的好处。拟议的软件将把目前的人工审查方法转变为全自动过程。随着现有内窥镜的扩展能力，拟议的短波系统预计将在这个价值100亿美元的行业中占有相当大的市场份额。其他受益于这项研究的医学领域包括支气管镜、结肠镜、肠镜、膀胱镜、腹腔镜和胶囊内窥镜。受益于这项技术的非医疗领域包括商业周边监控，以及供水和天然气管道检测-另一个数十亿美元的市场。

DESCRIPTION (provided by applicant): Gastrointestinal (GI) malignancies are the most common cause of cancer in the world. Of the 10.8 million people in the world each year who develop cancer, approximately 3.3 million have GI malignancies. Until recently, the only sections of the GI tract that could be imaged were the esophagus, stomach and colon through traditional endoscopy. Initial segments of the small bowel were imaged using techniques such as push enteroscopy or radioactive imaging techniques, but these methods present significant discomfort to the patients, costly, or lack sensitivity. Capsule endoscopy (CE) is a new technique that is changing the landscape of GI endoscopic diagnosis. CE is a widely acclaimed breakthrough in GI, especially small bowel imaging. However, current CE video display/analysis software (SW) is falling far behind. It has limitations including lengthy video viewing and interpreting time (e.g. ~2 hours) and is difficult in analyzing (e.g. visualizing) findings. These SW issues have incurred considerable amount of costs to patients, and need to be addressed urgently. To address this problem, together with our collaborators, we propose to develop a novel software system to fully automate the video review process and achieve comprehensive and accurate disease analysis. The proposed software system will have the following clinic impact and significance: 3/4 Fully automated and efficient disease detection and classification from CE videos; 3/4 Comprehensive visualization or analysis tool for more accurate disease diagnosis; 3/4 No more missing GI disorder areas from the review process; 3/4 A low cost SW system for better mass acceptance and effective disease prevention; and 3/4 Modular, expandable, and scalable technology. The proprietary software modular (functionally) technology developed can be easily applied to existing diagnosis instruments. The Millennium Research Group predicted the capsule endoscopy market to generate more than $180 million in 2009 in the United States alone - up from just $40 million in 2004. The predicted CAGR is 35.1% during 2008 - 2015. According to Given Imaging Ltd., more than one million patients worldwide have gone through capsule endoscopy procedure using their PillCam capsules. Capsule endoscopy is a rapidly-growing multi-billion dollar market (predicted to reach billion dollar mark in 2015 worldwide). The commercialization potential of the proposed software system and technology is significant. PUBLIC HEALTH RELEVANCE: The software system and technology developed under this SBIR project will provide great benefit to GI patients by providing cost saving and highly accurate GI tract disease finding and analysis software platform. The proposed software will transform the current manual review method into a fully automatic process. With the extended capability over current endoscopes, the proposed SW system is expected to have a reasonably large market share of this 10 billion dollar industry. Other medical areas benefitting from this research include bronchoscopy, colonoscopy, enteroscopy, cystoscopy, laparoscopy, and capsule endoscope. Non-medical fields to benefit this technology include commercial perimeter surveillance, and water and gas pipe inspection - another multi-billion market.