Real-time 3D Imaging Guided ART

 描述(申请人提供)：美国是世界上乳腺癌年发病率最高的国家。它是仅次于皮肤癌的第二大常见癌症，也是仅次于肺癌的第二大癌症死亡原因。。据估计，2014年，美国将新增1,665,540例癌症确诊病例和585,720例癌症死亡病例。在世界范围内，每年发现的乳腺癌新病例超过100万例。显然，一种有效或准确、微创、低成本的乳腺癌治疗方案将对挽救女性生命产生巨大的临床影响和意义。为了解决乳腺放射治疗(RT)面临的问题和技术挑战，我们与其合作者提出了一种完全不同的方法，称为4D SGRT技术，用于动态计算正在治疗的乳腺解剖结构，并自适应地重新计划放射治疗。该技术采用了一种基于非侵入性和自适应图像制导的方法。它消除了设置、移动性和变形带来的不确定性，实现了最佳交付。它还有望缩短乳房RT疗程，提高准确性，并减少最短的治疗设置时间。该项目的成功完成将为下一代乳房RT奠定基础，并使数百万乳腺癌患者能够及时受益于最新的技术进步。放射治疗市场正在迅速增长，预计到2020年，全球癌症年发病率将增加50%，主要原因是人口老龄化、吸烟者数量增加和不健康的生活方式。Fredonia Group估计，美国在癌症治疗方面拥有168亿美元的美国市场，而且还在以每年10%的速度增长。美国有2000多台放射治疗机，世界上还有更多的放射治疗机，临床上可以接受的3D相机自适应治疗系统的市场很大。

 DESCRIPTION (provided by applicant): The United States have the highest annual incidence rates of breast cancer in the word. It is the second-most common cancer (after skin cancer) and the second-most common cause of cancer death (after lung cancer). . It is estimated that, in 2014, there will be an estimated 1,665,540 new cancer cases diagnosed and 585,720 cancer deaths in the US. Worldwide more than one million new cases of breast cancer are found every year. Apparently, an effective or accurate, minimally invasive, and low-cost solution for breast cancer treatment will have enormous clinic impact and significance on saving women's lives. To address the problems and technical challenges facing breast radiation therapy (RT), together with its collaborator, we proposes a radically different methodology called 4D SGRT technology to dynamically compute on-treatment breast anatomy structure and adaptively re-plan the radiation therapy. The proposed technology uses a non-invasive and adaptive image guidance based methodology. It eliminates uncertainties due to setup, mobility, and deformation for optimized delivery. It is also expected to shortened breast RT session with improved accuracy, and reduces minimum treatment setup time. Successful completion of the project will provide foundation for the next generation breast RT, and make it possible for millions of breast cancer patients to benefit from the most recent technological advances in a timely fashion. The radiation therapy market is growing rapidly with annual cancer rates worldwide projected to increase by fifty percent by 2020, mainly due to aging population, increasing number of smokers and unhealthy life styles. The Fredonia Group estimated that U.S. has $16.8 billion US market for cancer therapies, and it is growing ten percent annually. With over 2,000 radiation treatment machines in the US and many more in the world, the market for a clinically acceptable 3D camera enabled adaptive therapy system is significant.