Augmenting Endoscopic Instruments with Real-time 3D Imaging

通过实时 3D 成像增强内窥镜仪器

• 批准号: 9339459
• 负责人: Steven Yi
• 金额: $ 34.57万
• 依托单位: XYKEN, LLC
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9339459
• 关键词: Address; Affect; Aging; Anatomy; Appearance; Appendicitis; Area; Biopsy; Bronchoscopy; Chronically Ill; Clinic; Clinical; Colon; Colonoscopes; Colonoscopy; Color; Computer software; Cystoscopy; Data; Depth Perception; Devices; Diagnosis; Diagnostic; Digestive System Disorders; Digit structure; Dimensions; Disease; Distal; Documentation; Dose; Elderly; Electronics; Endoscopes; Endoscopy; Equipment; Esophagus; Funding Opportunities; Gases; Gastrointestinal Diseases; Gastrointestinal tract structure; Growth; Hemorrhage; Image; Image-Guided Surgery; Imagery; Impairment; Industry; Inflammatory Bowel Diseases; Laparoscopy; Location; Maintenance; Measurement; Medical; Methods; Modeling; Office Visits; Operative Surgical Procedures; Optics; Patients; Phase; Polyps; Population; Positioning Attribute; Procedures; Process; Publishing; Radiation; Radiation therapy; Recovery; Rectum; Reporting; Research; Research Personnel; Risk; Small Business Innovation Research Grant; Small Intestines; Stomach; Stream; Surface; Surgeon; System; Tablets; Techniques; Technology; Testing; Texture; Therapeutic; Therapeutic Intervention; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Training; United States; United States National Institutes of Health; Virtual Endoscopy; Visual; Water; aging population; base; capsule; clinical Diagnosis; commercialization; cost; data exchange; design; digital; disease diagnosis; disorder prevention; economic impact; gastrointestinal; imaging system; in vivo; innovation; instrument; lens; miniaturize; minimally invasive; novel; operation; optical imaging; population based; prototype; response; retinal rods; sensor; simulation; software systems; therapeutic effectiveness; tool; two-dimensional

Project Summary: Aging increases the risk of GI disorders such as CRC, inflammatory bowel disease, and appendicitis. NIH statistic shows that 60 to 70 million people are affected by digestive diseases. Increasing global geriatric population base is expected to further worsen this situation over the coming years. Annually, diseases of the gastrointestinal (GI) tract account for more than 30 million office visits and more than 10 million GI endoscopic procedures in the United States alone for the examinations of digestive tract including the esophagus, stomach, small intestine, colon, and rectum. Minimally Invasive Surgery (MIS) endoscopes are still utilized as the main stream with close to $10 billon market needs and near double digit growth rate for performing both diagnosis and therapeutic clinic operations. Unfortunately, existing video based endoscopes can only provide 2D images for visual inspection purpose only, it cannot provide 3D quantitative information on volume and area and location of the disease, as well as the relative position of diagnostic and therapeutic equipment. To address this problem, Xyken together with its collaborator proposes to develop a novel imaging system to provide 2D/3D videoing of the GI anatomical structure. The proposed software system will have the following clinic impact and significance:  Greatly facilitating the diagnosis, planning, and treatment process through quantitative assessment, accurate depth perception and safer navigation  Providing more effective clinical training method for residents/doctors through in-vivo 3D digital GI tract model  Potentially replacing CT based image guided surgery – eliminating radiation and registration caused errors Published research reports find that, driven by the increasing number of the chronically ill population and aging, the global endoscopy equipment market is expected to reach USD 33.6 Billion by 2020 from USD 23.8 Billion in 2015, at a CAGR of 6.1%. With the aging population and advancement of the emerging economies, the global demand is expected to grow with an increased rate. The commercialization potential and economic impact of the proposed system is thus significant.

项目摘要： 衰老增加了胃肠道疾病的风险，例如CRC，炎症性肠病和 阑尾炎。 NIH统计数据表明，有60至7000万人受到消化系统疾病的影响。 预计全球老年人口基础将进一步恶化这种情况 年。每年，胃肠道（GI）的疾病占3000万以上的办公访问 仅在美国，就有超过1000万GI的内窥镜检查 消化道，包括食道，小肠，结肠和直肠。微创 手术（MIS）内窥镜仍被用作主要流，近10美元的Billon市场需求和 进行诊断和治疗性诊所操作的接近两位数增长率。 不幸的是，现有的基于视频的内窥镜只能提供2D图像进行视觉检查 仅目的，它不能提供有关数量，面积和位置的3D定量信息 疾病以及诊断和治疗设备的相对位置。解决这个问题 问题，Xyken及其合作者提案，以开发一种新型成像系统以提供 GI解剖结构的2D/3D视频。提议的软件系统将具有以下 诊所的影响和意义： 通过定量极大地支持诊断，计划和治疗过程 评估，准确的深度感知和安全导航 通过Vivo 3D数字为居民/医生提供更有效的临床培训方法 胃肠道模型 有可能替换基于CT的图像指导手术 - 消除辐射和注册 引起错误 已发表的研究报告发现，由于持续性不断增加的驱动 人口和衰老，全球内窥镜设备市场预计将达到336亿美元 2020年，2015年的238亿美元，复合年增长率为6.1％。随着人口老龄化和进步 在新兴经济中，预计全球需求将随着利率的提高而增长。这 因此，拟议系统的商业化潜力和经济影响很大。