Purchase of a 600 MHz NMR Spectrometer with Cryoprobe

购买带冷冻探针的 600 MHz NMR 波谱仪

基本信息

批准号：
7211806
负责人：
DENNIS P CURRAN
金额：
$ 49.28万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-01-15 至 2009-01-14
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Funds for the purchase of a 600 MHz BrukerBioSpin Avance-II nuclear magnetic resonance (NMR) spectrometer with a triple resonance (1H, 13C, 15N) high resolution CryoProbe are requested. The spectrometer will be integrated into the Chemistry Department Core NMR Facility and will serve a group of eight NIH-funded investigators as major users (Brummond, Curran, Floreancig, Koide, Nelson, Schafmeister, Wilcox, and Wipf) along with a number of minor users. The major users are supported by grant types including R01, P01, P50, U19 and U54, and funding institutes including the General Medical Institute, the National Cancer Institute, and the Institute of Allergy and Infectious Diseases. This user group requires more capacity for high-end NMR experiments and more sensitivity for small samples, and these needs dictate the requested instrument. There is a significant University commitment both for matching funds (1/1) for instrument purchase, and to renovate and configure suitable space on the ground floor of the Chevron Science Center (Chemistry Building). The Core NMR Facility is staffed by two PhD level NMR spectroscopists including a Director (who will be primarily responsible for the instrument) and an Assistant Director (who will run many of the spectra). Relevance: The spectrometer will support several dozen projects that have a strong biomedical relevance. These range from basic research on structure, reactions and interaction energies of biomolecules and related models, through new synthetic methods, to target identification and natural products total synthesis. There is a strong emphasis on innovative synthetic chemistry, and much of the work is directed towards drug discovery. This research often requires sophisticated NMR experiments on small samples, and the requested 600 MHz spectrometer will greatly expedite ongoing and planned work.

描述（由申请人提供）：购买具有三重共振（1H，13C，15N）高分辨率冷冻螺旋桨的600 MHz Brukerbiospin Avance-II核磁共振（NMR）光谱仪的资金。光谱仪将集成到化学部核心NMR设施中，并将作为主要用户（Brummond，Curran，Floreancig，Koide，Koide，Nelson，Nelson，Schafmeister，Wilcox和Wipf）提供一组由NIH资助的调查人员组成的小组，以及许多次要用户。主要用户得到了R01，P01，P50，U19和U54的赠款类型的支持，以及包括通用医学研究所，国家癌症研究所和过敏和传染病研究所在内的资助研究所。该用户组需要更多的高端NMR实验能力，并且对小样本的敏感性更高，这些需求决定了请求的仪器。既要购买仪器的资金（1/1），都有一项重要的大学承诺，并在雪佛龙科学中心（Chemistry Building）的一楼进行翻新和配置合适的空间。 NMR核心设施由两名PHD级别的NMR光谱学家组成，其中包括董事（主要负责该乐器）和一名助理主任（他们将运行许多Spectra）。相关性：光谱仪将支持几个具有强大生物医学相关性的项目。这些范围从生物分子和相关模型的结构，反应和相互作用能量的基础研究（通过新的合成方法）到靶标识别和天然产物的总合成。非常重视创新的合成化学，大部分工作都是针对药物发现的。这项研究通常需要在小样本上进行复杂的NMR实验，并且所需的600 MHz光谱仪将大大加快正在进行的和计划的工作。