ALZHEIMER'S DISEASE: MODELING PATHOLOGIC STRAIN-LIKE VARIANTS OF MULTIMERIC A?

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目的目标是确定聚集蛋白A的不同结构形式对大脑的影响。在阿尔茨海默病中，（一种通常由脑细胞产生的蛋白质）错误折叠并与其他A分子结合，形成老年斑和脑淀粉样血管病。我们的实验室已经表明，A？的聚集可以通过暴露于阿尔茨海默病患者的脑提取物来刺激。在过去的一年里，我们已经开始研究分离种子本身，以评估其诱导聚集的能力，并确定是否有不同的结构/功能亚型的A？

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this project is to define the effects of different structural forms of the aggregated protein A¿ on the brain. In Alzheimer's disease, A¿ (a protein normally generated by brain cells) becomes misfolded and binds to other A¿ molecules, forming senile plaques and cerebral amyloid angiopathy. Our lab has shown that the aggregation of A¿ can be stimulated by exposure to brain extracts from patients with Alzheimer's disease. This past year we have begun studies to isolate the seed itself, to assess its ability to induce aggregation, and to determine whether there are different structural/functional subtypes of A¿.