ALZHEIMER'S DISEASE: MODELING PATHOLOGIC STRAIN-LIKE VARIANTS OF MULTIMERIC A?
ALZHEIMER'S DISEASE: MODELING PATHOLOGIC STRAIN-LIKE VARIANTS OF MULTIMERIC A?
批准号:
8172438
负责人:
LARY C WALKER
金额:
$2.74万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2010
资助国家:
美国
项目状态:
已结题
起止时间:
2010-05-01 至 2011-04-30
关键词:
AffinityAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAmino Acid SequenceBindingBinding SitesComputer Retrieval of Information on Scientific Projects DatabaseDiseaseFundingGrantHumanInstitutionInvestigationNaturePathologicPittsburgh Compound-BResearchResearch PersonnelResourcesShapesSiteSourceUnited States National Institutes of HealthVariantnonhuman primateprotein aggregate
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
In the past year, we have continued and expanded our analysis of strain-like structural variants of multimeric aggregates of the protein A¿. We have shown that, unlike in Alzheimer's disease, naturally occurring A¿ in nonhuman primates does not bind the A¿-binding ligand PIB with high affinity, despite an identical amino acid sequence. This finding suggests that PIB may recognize a polymorphic site on multimeric A¿.
Unexpectedly, in the course of this investigation, we also discovered a single case of Alzheimer's disease with very high A¿ levels, yet negligible high-affinity PIB binding, indicating that the binding site may vary among humans with the disease. The findings support growing evidence that protein aggregates may assume several multidimensional shapes that could govern their pathogenic nature.
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Cerebral small vessel disease: Enhancing the diagnostic precision of MRI
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批准号:8325607
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项目类别:
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资助金额:$22.0万
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财政年份:2011
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负责人:LARY C WALKER
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依托单位:
ALZHEIMER'S DISEASE: MODELING PATHOLOGIC STRAIN-LIKE VARIANTS OF MULTIMERIC A?
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批准号:8357481
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项目类别:
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资助金额:$2.06万
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财政年份:2011
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负责人:LARY C WALKER
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依托单位:
Cerebral small vessel disease: Enhancing the diagnostic precision of MRI
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批准号:8226423
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项目类别:
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资助金额:$25.64万
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财政年份:2011
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负责人:LARY C WALKER
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依托单位:
ALZHEIMER'S DISEASE: MODELING PATHOLOGIC STRAIN-LIKE VARIANTS OF MULTIMERIC A?
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批准号:7958265
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项目类别:
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资助金额:$2.75万
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财政年份:2009
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负责人:LARY C WALKER
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依托单位:
BIOMARKERS BRAIN PATHOLOGY: RISKS FOR ALZHEIMER?S DISEASE AND DRUG ADDICTION
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批准号:7715793
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项目类别:
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资助金额:$2.85万
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财政年份:2008
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负责人:LARY C WALKER
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依托单位:
ALZHEIMER'S IMMUNOTHERAPY IN A PRIMATE MODEL OF CEREBRAL AMYLOID ANGIOPATHY
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批准号:7715794
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项目类别:
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资助金额:$2.85万
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财政年份:2008
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负责人:LARY C WALKER
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依托单位:
TRANSGENIC EXPRESSION OF TAU AND APP IN MODELS OF ALZHEIMER'S DISEASE
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批准号:7715792
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项目类别:
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资助金额:$3.56万
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财政年份:2008
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负责人:LARY C WALKER
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依托单位:
EXOGENOUS INDUCTION OF ALZHEIMER A?-PATHOLOGY IN TRANSGENIC MICE
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批准号:7715846
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项目类别:
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资助金额:$2.85万
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财政年份:2008
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负责人:LARY C WALKER
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依托单位:
TRANSGENIC EXPRESSION OF TAU AND APP IN MODELS OF ALZHEIMER'S DISEASE
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批准号:7562655
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项目类别:
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资助金额:$3.95万
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财政年份:2007
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负责人:LARY C WALKER
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依托单位:
BIOMARKERS BRAIN PATHOLOGY: RISKS FOR ALZHEIMER?S DISEASE AND DRUG ADDICTION
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批准号:7562656
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项目类别:
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资助金额:$3.16万
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财政年份:2007
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负责人:LARY C WALKER
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依托单位:
ALZHEIMER'S IMMUNOTHERAPY IN A PRIMATE MODEL OF CEREBRAL AMYLOID ANGIOPATHY
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批准号:7562657
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项目类别:
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资助金额:$3.95万
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财政年份:2007
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负责人:LARY C WALKER
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依托单位:
LENTIVIRAL-MEDIATED EXPRESSION OF TRANSGENIC BETA-APP AND PRESENILIN IN MONKEYS
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批准号:7562590
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项目类别:
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资助金额:$3.16万
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财政年份:2007
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负责人:LARY C WALKER
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依托单位:
LENTIVIRAL-MEDIATED EXPRESSION OF TRANSGENIC BETA-APP AND PRESENILIN IN MONKEYS
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批准号:7349251
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项目类别:
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资助金额:$4.01万
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财政年份:2006
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负责人:LARY C WALKER
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依托单位:
Defining the Properties of Pathogenic A-beta strains in AD
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批准号:9280785
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项目类别:
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资助金额:$19.5万
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财政年份:2005
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负责人:LARY C WALKER
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依托单位:
LENTIVIRAL-MEDIATED EXPRESSION OF TRANSGENIC BETA-APP AND PRESENILIN IN MONKEYS
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批准号:7166007
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项目类别:
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资助金额:$3.08万
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财政年份:2005
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负责人:LARY C WALKER
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依托单位:
Defining the Properties of Pathogenic A-beta strains in AD
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批准号:8849145
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项目类别:
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资助金额:$20.15万
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财政年份:2005
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负责人:LARY C WALKER
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依托单位:
Defining the Properties of Pathogenic A-beta strains in AD
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批准号:9088278
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项目类别:
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资助金额:$18.48万
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财政年份:2005
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负责人:LARY C WALKER
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依托单位:
A NEW MODEL OF ALZHEIMER'S DISEASE PATHOGENESIS
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批准号:6971062
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项目类别:
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资助金额:$3.44万
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财政年份:2004
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负责人:LARY C WALKER
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依托单位:
CORE--TRAINING AND INFORMATION TRANSFER
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批准号:6267355
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项目类别:
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资助金额:$13.27万
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财政年份:1998
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负责人:LARY C WALKER
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依托单位:
CORE--TRAINING AND INFORMATION TRANSFER
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批准号:6098079
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项目类别:
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资助金额:$0.0万
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财政年份:1998
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负责人:LARY C WALKER
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依托单位: