BIOMARKERS BRAIN PATHOLOGY: RISKS FOR ALZHEIMER?S DISEASE AND DRUG ADDICTION

生物标志物脑病理学：阿尔茨海默病和药物成瘾的风险

• 批准号: 7562656
• 负责人: LARY C WALKER
• 金额: $ 3.16万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562656
• 关键词: 4-vinyl-1-cyclohexene dioxide; Alzheimer' s Disease; Alzheimer' s disease risk; Animal Model; Biological Markers; Brain Pathology; Breeding; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug Addiction; Funding; Genes; Grant; Hormonal; Hormonal Change; Human; Institution; Lesion; Mass Spectrum Analysis; Menopause; Modeling; Mus; Ovary; Primordial Follicle; Proteins; Research; Research Personnel; Resources; Senile Plaques; Source; Transgenic Mice; United States National Institutes of Health; Woman; mutant; novel; senescence

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This venture subproject is developing a novel model of menopause to determine why women are more vulnerable to Alzheimer's disease, and to examine protein biomarkers for this disorder. Presently, there are few physiologically relevant animal models of menopause that faithfully mimic the hormonal changes that occur in humans. However, exposure of mice to the chemical 4-vinylcyclohexene diepoxide results in the loss of primary and primordial follicles in the ovary, resulting in a state that closely resembles menopause, including reproducible hormonal and cyclical senescence in young mice. The transgenic mice (which have a mutant human gene that causes senile plaques like those in Alzheimer's disease) are presently being bred and treated with 4-vinylcyclohexene diepoxide, and the effects of experimental menopause on the genesis of A¿ lesions in ¿APP-transgenic mice will be examined using mass spectrometry.

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 该风险投影正在开发一种新型更年期模型，以确定女性为什么更容易患阿尔茨海默氏病，并检查这种疾病的蛋白质生物标志物。目前，很少有与物理相关的更年期动物模型忠实地模仿人类发生的马匹变化。然而，小鼠暴露于化学4-乙烯基己烯二氧化二氧化二氧化二氧化二氧化二氧化物导致卵巢中原发性和原始易位的丧失，从而导致与更年期相似的状态，包括幼体中可再现的激素和周期性敏感性。目前正在繁殖并用4-乙烯基环己烯二氧化二氧化氧化二氧化二氧化氧化氧化物和群体群中，经过实验性的杂种对A的生成对App-Transgenic Massepronemention进行了检查。