BIOMARKERS BRAIN PATHOLOGY: RISKS FOR ALZHEIMER?S DISEASE AND DRUG ADDICTION

生物标志物脑病理学：阿尔茨海默病和药物成瘾的风险

• 批准号: 7562656
• 负责人: LARY C WALKER
• 金额: $ 3.16万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562656
• 关键词: 4-vinyl-1-cyclohexene dioxide; Alzheimer' s Disease; Alzheimer' s disease risk; Animal Model; Biological Markers; Brain Pathology; Breeding; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Disease; Drug Addiction; Funding; Genes; Grant; Hormonal; Hormonal Change; Human; Institution; Lesion; Mass Spectrum Analysis; Menopause; Modeling; Mus; Ovary; Primordial Follicle; Proteins; Research; Research Personnel; Resources; Senile Plaques; Source; Transgenic Mice; United States National Institutes of Health; Woman; mutant; novel; senescence

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This venture subproject is developing a novel model of menopause to determine why women are more vulnerable to Alzheimer's disease, and to examine protein biomarkers for this disorder. Presently, there are few physiologically relevant animal models of menopause that faithfully mimic the hormonal changes that occur in humans. However, exposure of mice to the chemical 4-vinylcyclohexene diepoxide results in the loss of primary and primordial follicles in the ovary, resulting in a state that closely resembles menopause, including reproducible hormonal and cyclical senescence in young mice. The transgenic mice (which have a mutant human gene that causes senile plaques like those in Alzheimer's disease) are presently being bred and treated with 4-vinylcyclohexene diepoxide, and the effects of experimental menopause on the genesis of A¿ lesions in ¿APP-transgenic mice will be examined using mass spectrometry.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个创业子项目正在开发一种新的更年期模型，以确定为什么女性更容易患阿尔茨海默病，并检查这种疾病的蛋白质生物标记物。目前，很少有生理上相关的更年期动物模型能忠实地模拟人类体内发生的荷尔蒙变化。然而，小鼠暴露在化学物质4-乙烯基环己烯二环氧化物中会导致卵巢中初级和原始卵泡的丧失，导致一种非常类似更年期的状态，包括幼鼠可复制的荷尔蒙和周期性衰老。这些转基因小鼠(带有突变的人类基因，会导致阿尔茨海默病中的老年斑)目前正在培育中，并使用4-乙烯基环己烯二环氧化物进行治疗，将使用质谱仪检测实验性绝经对APP转基因小鼠A？病变发生的影响。