BIOMARKERS BRAIN PATHOLOGY: RISKS FOR ALZHEIMER?S DISEASE AND DRUG ADDICTION

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This venture subproject is developing a novel model of menopause to determine why women are more vulnerable to Alzheimer's disease, and to examine protein biomarkers for this disorder. Presently, there are few physiologically relevant animal models of menopause that faithfully mimic the hormonal changes that occur in humans. However, exposure of mice to the chemical 4-vinylcyclohexene diepoxide results in the loss of primary and primordial follicles in the ovary, resulting in a state that closely resembles menopause, including reproducible hormonal and cyclical senescence in young mice. The transgenic mice (which have a mutant human gene that causes senile plaques like those in Alzheimer's disease) are presently being bred and treated with 4-vinylcyclohexene diepoxide, and the effects of experimental menopause on the genesis of A¿ lesions in ¿APP-transgenic mice will be examined using mass spectrometry.