ALZHEIMER'S IMMUNOTHERAPY IN A PRIMATE MODEL OF CEREBRAL AMYLOID ANGIOPATHY

脑淀粉样血管病灵长类动物模型中的阿尔茨海默病免疫治疗

• 批准号: 7715794
• 负责人: LARY C WALKER
• 金额: $ 2.85万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715794
• 关键词: Age; Alzheimer' s Disease; Amyloidosis; Antibody Formation; Antigens; B-Lymphocytes; Blood Vessels; Cerebral Amyloid Angiopathy; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Grant; Immunization; Immunology; Immunotherapy; Institution; Modeling; Monkeys; Plasma; Primates; Proteins; Reporting; Research; Research Personnel; Resources; Safety; Saimiri; Source; United States National Institutes of Health; aged

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A¿-immunization is a promising new therapy for Alzheimer's disease, but safety issues need to be resolved. This project is investigating the effects of A¿-immunization in the squirrel monkey, a species that develops significant vascular ¿-amyloidosis with age. During the reporting period, we showed that short-term immunization of older squirrel monkeys against the A¿ protein, which is critical to the development of Alzheimer's disease, is safe and is able to induce significant antibody formation. Long term immunization of additional monkeys is in progress. We have shown antibody production in one of 2 immunized aged monkeys, as well as evidence of immunogen-activated plasma B-cells (in collaboration with the Immunology Core).

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 免疫接种是治疗阿尔茨海默病的一种很有前途的新疗法，但安全性问题需要解决。该项目正在调查A免疫在松鼠猴身上的效果，松鼠猴是一种随着年龄增长而患上显著血管淀粉样变性的物种。在本报告所述期间，我们表明，对老年松鼠猴子进行针对A？蛋白的短期免疫是安全的，并能够诱导大量抗体形成。A？蛋白对阿尔茨海默病的发展至关重要。对更多猴子的长期免疫正在进行中。我们已经展示了两只免疫的老年猴子中的一只产生抗体，以及免疫原激活的血浆B细胞的证据(与免疫学核心合作)。