HEMISPHERIC SPECIALIZATION AND COMMUNICATION

半球专业化和沟通

• 批准号: 8357394
• 负责人: WILLIAM D HOPKINS
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357394
• 关键词: Area; Broca' s area; Cerebral Dominance; Communication; Computer software; Development; Dimensions; Face; Funding; Grant; Laboratories; Magnetic Resonance Imaging; National Center for Research Resources; Pan Genus; Population; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Sampling; Source; Surface; Sylvius fissure; Thick; United States National Institutes of Health; Variant; Wernicke Area; behavior measurement; cost; frontal lobe; gray matter; motor control; novel; orbital sulcus; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This year, studies in our laboratory focused on the development and implementation of a novel software program that allows for the automated extraction of cortical sulci from magnetic resonance images. The sucli can then be quantified on a number of dimensions including surface area, mean and maximum depth, grey matter thickness and fold opening. Our initial studies were conducted in a sample of 84 chimpanzees and we found significant population-level asymmetries for a number of sulci, notably the sylvian fissure and fronto-orbital sulcus, sulci that are landmarks used to delineate Broca's and Wernicke's areas. We further found that variation in the volumes and asymmetries of the frontal lobe sulci were associated with behavioral measures of oro-facial motor control in the chimpanzees.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 今年，我们实验室的研究集中在一个新的软件程序的开发和实施，允许从磁共振图像中自动提取皮质沟。 然后，可以在许多维度上量化支持物，包括表面积、平均和最大深度、灰质厚度和褶皱开口。 我们最初的研究是在84只黑猩猩的样本中进行的，我们发现一些脑沟存在显著的人口水平不对称性，特别是外侧裂和额眶沟，这些脑沟是用于描绘Broca和Wernicke区域的地标。我们进一步发现，黑猩猩额叶沟的体积和不对称性的变化与口面部运动控制的行为测量有关。