Specific Pathogen Free 18 Baboon Research Resource (SPF18BRR)

无特定病原体 18 狒狒研究资源 (SPF18BRR)

• 批准号: 10912917
• 负责人: WILLIAM D HOPKINS
• 金额: $ 27.01万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10912917
• 关键词: 15 year old; 3 year old; Address; Adult; Age; Aging; Alzheimer' s disease related dementia; Animal Experimentation; Animal Model; Animals; Applied Research; Bacteremia; Bacterial Model; Biocompatible Materials; Biological; Biological Markers; Biology; Biomedical Research; Breeding; COVID-19 pneumonia; COVID-19 vaccine; Caregivers; Cognition; Communities; DNA Methylation; Data; Data Management Resources; Databases; Development; Diabetes Mellitus; Discipline; Doctor of Philosophy; Epigenetic Process; Family suidae; Female; Foundations; Future; General Population; Genetic; Genetic Engineering; Genetic Variation; Genomics; Goals; Grant; Health Sciences; Immunobiology; Intramural Research Program; Laboratory Animals; Methods; Modeling; Monitor; Neurosciences; Oklahoma; Papio; Papio anubis; Pertussis; Pharmacologic Substance; Plasma; Primates; Privatization; Production; Research; Research Contracts; Research Personnel; Research Project Grants; Resources; Respiratory syncytial virus; Scientist; Services; Students; System; Tissues; Training; Training and Education; United States National Institutes of Health; Universities; Veterinarians; Virus; Work; Xenograft procedure; age group; animal breeding; animal care; animal resource; cognitive testing; design; genetic analysis; genetic pedigree; genome sequencing; germ free condition; human disease; human model; improved; male; next generation; nonhuman primate; novel; offspring; pathogen; programs; social; tool; training opportunity; virus resource; web site; whole genome

PROJECT SUMMARY: OVERALL COMPONENT This application is a competing renewal of the “Specific Pathogen Free 18 Baboon Research Resource” (SPF18BRR) P40 OD024628. The SPF18BRR was founded with NIH support at the University of Oklahoma Health Sciences Center (OUHSC) in 2002 and was relocated to the Keeling Center in 2017. The SPF18BRR has received continuous NIH support since it was founded. The SPF18BRR is the only national research resource of adventitious virus free olive baboons (Papio anubis) that are available to NIH grantees; intramural research programs of federal agencies, including the FDA, NSF and NIH; and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Absolutely unique in the entire world, the baboons in the SPF18BRR have an extensive bioexclusion list of 18 pathogens normally found in other wild and captive nonhuman primate colonies. The SPF18BRR has integrated multiple disciplines into a program designed to meet the needs of investigators who utilize its resources. During the proposed period of support, the SPF18BRR will continue to improve the resources it provides to users and will continue to add new information about the biology and research value of virus free baboons to its website. Baboons continue to be important animal model for genetically engineered pig xenotransplantation, are the only NHP model of respiratory syncytial virus and whooping cough, and they remain a very important model of bacterial sepsis. Additionally, baboons are excellent models of human COVID associated pneumonia, and they were instrumental in the development of approved vaccines for SARS CoV-2. Over the next five years, the SPF18BRR will focus on expanding the SPF18 baboon breeding colony to meet current and future biomedical research needs. The aims of the Resource Core Component address our continued commitment to expanding the SPF18 baboon breeding colony, we will increase the genetic diversity of the SPF18 breeding colony, and we will provide SPF18 baboons, facilities, training, and expertise to the scientific community. The Applied Research Component will include projects to develop methods to train and collect data from automated cognitive testing systems in socially living baboons; we will also determine a DNA methylation clock for our baboon colony, and will perform baseline biomarker analysis for a panel of 30 biomarkers for all animals over 3 years old in our colony; and, we will perform whole genome sequencing on 9 future conventional baboon breeders from the Southwest National Primate Center’s olive baboon colony, as well as targeted genomic sequencing on other interesting animals from the SPF18BRR. The overall goals of theSPF18BRR are to provide a national research resource of virus free olive baboons; provide baboon derived biological materials; provide education and training opportunities to scientist, colony managers, and animal caregivers who want to work with baboons; and to provide investigators with facilities and expertise to conduct studies using virus free baboons.

项目概要：总体组成部分 此应用程序是“无特定病原体 18 狒狒研究资源”的竞争性更新 (SPF18BRR) P40 OD024628。 SPF18BRR 在 NIH 的支持下在俄克拉荷马大学成立 健康科学中心 (OUHSC) 于 2002 年成立，并于 2017 年搬迁至基林中心。 SPF18BRR 自成立以来一直得到 NIH 的支持。 SPF18BRR是唯一的国家研究 NIH 受资助者可获得的外来病毒无病毒橄榄狒狒 (Papio anubis) 资源；壁内 联邦机构的研究项目，包括 FDA、NSF 和 NIH；以及其他生物医学赞助商 研究（私人基金会、制药公司和合同研究组织）。绝对地 SPF18BRR 中的狒狒拥有包含 18 种病原体的广泛生物排除清单，这在全世界都是独一无二的 通常发现于其他野生和圈养的非人类灵长类动物群体中。 SPF18BRR 集成了多个 学科纳入旨在满足利用其资源的调查人员的需求的计划。期间 在提议的支持期内，SPF18BRR 将继续改进为用户提供的资源， 将继续在其网站上添加有关无病毒狒狒的生物学和研究价值的新信息。 狒狒仍然是基因工程猪异种移植的重要动物模型， 呼吸道合胞病毒和百日咳的唯一NHP模型，它们仍然是一个非常重要的模型 细菌性败血症。此外，狒狒是人类新冠肺炎相关肺炎的优秀模型，并且 他们在开发经批准的 SARS CoV-2 疫苗方面发挥了重要作用。未来五年， SPF18BRR 将专注于扩大 SPF18 狒狒繁殖群体，以满足当前和未来的需求 生物医学研究的需要。资源核心组件的目标是解决我们持续的问题 致力于扩大 SPF18 狒狒繁殖群体，我们将增加狒狒的遗传多样性 SPF18 繁殖群，我们将为科研人员提供 SPF18 狒狒、设施、培训和专业知识 社区。应用研究部分将包括开发培训和收集方法的项目 来自群居狒狒的自动认知测试系统的数据；我们还将确定 DNA 我们的狒狒群体的甲基化时钟，并将针对 30 人的小组进行基线生物标志物分析 我们群体中所有 3 岁以上动物的生物标志物；并且，我们将进行全基因组测序 来自西南国家灵长类动物中心橄榄狒狒栖息地的 9 名未来传统狒狒饲养员，如 以及对来自 SPF18BRR 的其他有趣动物进行靶向基因组测序。总体目标 SPF18BRR 的目的是提供国家无病毒橄榄狒狒研究资源；提供 狒狒衍生的生物材料；为科学家、殖民地提供教育和培训机会 想要与狒狒一起工作的管理者和动物护理人员；并为调查人员提供 使用无病毒狒狒进行研究的设施和专业知识。

项目成果

Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons.

• DOI: 10.1111/xen.12715
• 发表时间: 2021-11
• 期刊: XENOTRANSPLANTATION
• 影响因子: 3.9
• 作者: Foote, Jeremy B.;Jagdale, Abhijit;Yamamoto, Takayuki;Hara, Hidetaka;Bikhet, Mohamed H.;Schuurman, Henk-Jan;Nguyen, Huy Q.;Ezzelarab, Mohamed;Ayares, David;Anderson, Douglas J.;Fatima, Huma;Eckhoff, Devin E.;Cooper, David K. C.;Iwase, Hayato
• 通讯作者: Iwase, Hayato

Observations on hydronephrosis after pig kidney transplantation in baboons.

• DOI: 10.1111/xen.12779
• 发表时间: 2022-11
• 期刊: XENOTRANSPLANTATION
• 影响因子: 3.9
• 作者: Foote, Jeremy B.;Bikhet, Mohamed H.;Hansen-Estruch, Christophe;Javed, Mariyam;Ayares, David;Hara, Hidetaka;Humar, Abhinav;Eckhoff, Devin E.;Cooper, David K. C.
• 通讯作者: Cooper, David K. C.

Physiological aspects of pig kidney xenotransplantation and implications for management following transplant.

• DOI: 10.1111/xen.12743
• 发表时间: 2022-05
• 期刊: XENOTRANSPLANTATION
• 影响因子: 3.9
• 作者: Hansen-Estruch, Christophe;Cooper, David K. C.;Judd, Eric
• 通讯作者: Judd, Eric

T and B lymphocyte dynamics after genetically-modified pig-to-baboon kidney xenotransplantation with an anti-CD40mAb-based immunosuppressive regimen.

• DOI: 10.1016/j.trim.2022.101545
• 发表时间: 2022-04
• 期刊: TRANSPLANT IMMUNOLOGY
• 影响因子: 1.5
• 作者: Jagdale, Abhijit;Huy Nguyen;Iwase, Hayato;Foote, Jeremy B.;Yamamoto, Takayuki;Javed, Mariyam;Ayares, David;Anderson, Douglas J.;Eckhoff, Devin E.;Cooper, David K. C.;Hara, Hidetaka
• 通讯作者: Hara, Hidetaka

A global catalog of whole-genome diversity from 233 primate species

• DOI: 10.1126/science.abn7829
• 发表时间: 2023-06-02
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Kuderna，Lukas F. K.;Gao，Hong;Bonet，Tomas Marques
• 通讯作者: Bonet，Tomas Marques