Specific Pathogen Free 18 Baboon Research Resource (SPF18BRR)

无特定病原体 18 狒狒研究资源 (SPF18BRR)

• 批准号: 10912917
• 负责人: WILLIAM D HOPKINS
• 金额: $ 27.01万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10912917
• 关键词: 15 year old; 3 year old; Address; Adult; Age; Aging; Alzheimer' s disease related dementia; Animal Experimentation; Animal Model; Animals; Applied Research; Bacteremia; Bacterial Model; Biocompatible Materials; Biological; Biological Markers; Biology; Biomedical Research; Breeding; COVID-19 pneumonia; COVID-19 vaccine; Caregivers; Cognition; Communities; DNA Methylation; Data; Data Management Resources; Databases; Development; Diabetes Mellitus; Discipline; Doctor of Philosophy; Epigenetic Process; Family suidae; Female; Foundations; Future; General Population; Genetic; Genetic Engineering; Genetic Variation; Genomics; Goals; Grant; Health Sciences; Immunobiology; Intramural Research Program; Laboratory Animals; Methods; Modeling; Monitor; Neurosciences; Oklahoma; Papio; Papio anubis; Pertussis; Pharmacologic Substance; Plasma; Primates; Privatization; Production; Research; Research Contracts; Research Personnel; Research Project Grants; Resources; Respiratory syncytial virus; Scientist; Services; Students; System; Tissues; Training; Training and Education; United States National Institutes of Health; Universities; Veterinarians; Virus; Work; Xenograft procedure; age group; animal breeding; animal care; animal resource; cognitive testing; design; genetic analysis; genetic pedigree; genome sequencing; germ free condition; human disease; human model; improved; male; next generation; nonhuman primate; novel; offspring; pathogen; programs; social; tool; training opportunity; virus resource; web site; whole genome

PROJECT SUMMARY: OVERALL COMPONENT This application is a competing renewal of the “Specific Pathogen Free 18 Baboon Research Resource” (SPF18BRR) P40 OD024628. The SPF18BRR was founded with NIH support at the University of Oklahoma Health Sciences Center (OUHSC) in 2002 and was relocated to the Keeling Center in 2017. The SPF18BRR has received continuous NIH support since it was founded. The SPF18BRR is the only national research resource of adventitious virus free olive baboons (Papio anubis) that are available to NIH grantees; intramural research programs of federal agencies, including the FDA, NSF and NIH; and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Absolutely unique in the entire world, the baboons in the SPF18BRR have an extensive bioexclusion list of 18 pathogens normally found in other wild and captive nonhuman primate colonies. The SPF18BRR has integrated multiple disciplines into a program designed to meet the needs of investigators who utilize its resources. During the proposed period of support, the SPF18BRR will continue to improve the resources it provides to users and will continue to add new information about the biology and research value of virus free baboons to its website. Baboons continue to be important animal model for genetically engineered pig xenotransplantation, are the only NHP model of respiratory syncytial virus and whooping cough, and they remain a very important model of bacterial sepsis. Additionally, baboons are excellent models of human COVID associated pneumonia, and they were instrumental in the development of approved vaccines for SARS CoV-2. Over the next five years, the SPF18BRR will focus on expanding the SPF18 baboon breeding colony to meet current and future biomedical research needs. The aims of the Resource Core Component address our continued commitment to expanding the SPF18 baboon breeding colony, we will increase the genetic diversity of the SPF18 breeding colony, and we will provide SPF18 baboons, facilities, training, and expertise to the scientific community. The Applied Research Component will include projects to develop methods to train and collect data from automated cognitive testing systems in socially living baboons; we will also determine a DNA methylation clock for our baboon colony, and will perform baseline biomarker analysis for a panel of 30 biomarkers for all animals over 3 years old in our colony; and, we will perform whole genome sequencing on 9 future conventional baboon breeders from the Southwest National Primate Center’s olive baboon colony, as well as targeted genomic sequencing on other interesting animals from the SPF18BRR. The overall goals of theSPF18BRR are to provide a national research resource of virus free olive baboons; provide baboon derived biological materials; provide education and training opportunities to scientist, colony managers, and animal caregivers who want to work with baboons; and to provide investigators with facilities and expertise to conduct studies using virus free baboons.

项目总结：总体构成部分 本申请是对《无特定病原体18只浣熊研究资源》的竞争性更新 (SPF18BRR)P40 OD024628。SPF18BRR是在俄克拉何马大学NIH的支持下成立的 卫生科学中心(OUHSC)于2002年成立，并于2017年迁至基林中心。SPF18BRR 自NIH成立以来，它一直得到NIH的支持。SPF18BRR是唯一一项全国性研究 美国国立卫生研究院资助的不定病毒无病毒橄榄狒狒(Papio Anubis)资源；壁内 联邦机构的研究计划，包括FDA、NSF和NIH；以及生物医学的其他赞助商 研究(私人基金会、制药公司和合同研究组织)。绝对一点儿没错 在整个世界上都是独一无二的，SPF18BRR中的狒狒有18种病原体的广泛生物排斥名单 通常在其他野生和圈养的非人类灵长类动物群体中发现。SPF18BRR集成了多个 该方案旨在满足利用其资源的调查人员的需求。在.期间 在拟议的支持期内，SPF18BRR将继续改进其向用户提供的资源，并 将继续在其网站上添加有关无病毒狒狒的生物学和研究价值的新信息。 狒狒仍然是基因工程猪异种移植的重要动物模型，是 只有呼吸道合胞病毒和百日咳的NHP模型，它们仍然是一个非常重要的模型 细菌性败血症。此外，狒狒是人类COVID相关性肺炎的优秀模型，以及 他们在开发批准的SARS CoV-2疫苗方面发挥了重要作用。在接下来的五年， SPF18BRR将专注于扩大SPF18狒狒繁殖群体，以满足当前和未来的需求 生物医学研究需要。资源核心组件的目标满足我们的后续需求 致力于扩大SPF18狒狒繁育群体，我们将增加其遗传多样性 SPF18繁殖地，我们将为SPF18狒狒提供设施、培训和专业知识 社区。应用研究部分将包括开发培训和收集方法的项目 来自自动认知测试系统的数据；我们还将确定一种DNA 甲基化时钟，并将对30个小组进行基线生物标记物分析 所有3岁以上动物的生物标志物；我们将对 来自西南国家灵长类中心橄榄狒狒聚居地的9名未来的传统狒狒繁殖者， 以及对来自SPF18BRR的其他有趣动物的定向基因组测序。总体目标 SPF18BRR的主要任务是提供全国性的无病毒橄榄狒狒研究资源；提供 狒狒衍生生物材料；为科学家、蜂群提供教育和培训机会 管理人员和动物护理员，他们想要与狒狒一起工作；并为调查人员提供 使用无病毒的狒狒进行研究的设施和专业知识。

项目成果

Histopathology of pig kidney grafts with/without expression of the carbohydrate Neu5Gc in immunosuppressed baboons.

• DOI: 10.1111/xen.12715
• 发表时间: 2021-11
• 期刊: XENOTRANSPLANTATION
• 影响因子: 3.9
• 作者: Foote, Jeremy B.;Jagdale, Abhijit;Yamamoto, Takayuki;Hara, Hidetaka;Bikhet, Mohamed H.;Schuurman, Henk-Jan;Nguyen, Huy Q.;Ezzelarab, Mohamed;Ayares, David;Anderson, Douglas J.;Fatima, Huma;Eckhoff, Devin E.;Cooper, David K. C.;Iwase, Hayato
• 通讯作者: Iwase, Hayato

Observations on hydronephrosis after pig kidney transplantation in baboons.

• DOI: 10.1111/xen.12779
• 发表时间: 2022-11
• 期刊: XENOTRANSPLANTATION
• 影响因子: 3.9
• 作者: Foote, Jeremy B.;Bikhet, Mohamed H.;Hansen-Estruch, Christophe;Javed, Mariyam;Ayares, David;Hara, Hidetaka;Humar, Abhinav;Eckhoff, Devin E.;Cooper, David K. C.
• 通讯作者: Cooper, David K. C.

Physiological aspects of pig kidney xenotransplantation and implications for management following transplant.

• DOI: 10.1111/xen.12743
• 发表时间: 2022-05
• 期刊: XENOTRANSPLANTATION
• 影响因子: 3.9
• 作者: Hansen-Estruch, Christophe;Cooper, David K. C.;Judd, Eric
• 通讯作者: Judd, Eric

T and B lymphocyte dynamics after genetically-modified pig-to-baboon kidney xenotransplantation with an anti-CD40mAb-based immunosuppressive regimen.

• DOI: 10.1016/j.trim.2022.101545
• 发表时间: 2022-04
• 期刊: TRANSPLANT IMMUNOLOGY
• 影响因子: 1.5
• 作者: Jagdale, Abhijit;Huy Nguyen;Iwase, Hayato;Foote, Jeremy B.;Yamamoto, Takayuki;Javed, Mariyam;Ayares, David;Anderson, Douglas J.;Eckhoff, Devin E.;Cooper, David K. C.;Hara, Hidetaka
• 通讯作者: Hara, Hidetaka

A global catalog of whole-genome diversity from 233 primate species

• DOI: 10.1126/science.abn7829
• 发表时间: 2023-06-02
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Kuderna，Lukas F. K.;Gao，Hong;Bonet，Tomas Marques
• 通讯作者: Bonet，Tomas Marques