Specific Pathogen Free 18 Baboon Research Resource (SPF18BRR)

无特定病原体 18 狒狒研究资源 (SPF18BRR)

• 批准号: 10627136
• 负责人: WILLIAM D HOPKINS
• 金额: $ 127.46万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627136
• 关键词: 15 year old; 3 year old; Address; Adult; Age; Aging; Alzheimer' s disease related dementia; Animal Experimentation; Animal Model; Animals; Applied Research; Bacteremia; Bacterial Model; Biocompatible Materials; Biological; Biological Markers; Biology; Biomedical Research; Breeding; COVID-19 pneumonia; COVID-19 vaccine; Caregivers; Cognition; Communities; DNA Methylation; Data; Data Management Resources; Databases; Development; Diabetes Mellitus; Discipline; Doctor of Philosophy; Epigenetic Process; Family suidae; Female; Foundations; Future; General Population; Genetic; Genetic Engineering; Genetic Variation; Genomics; Goals; Grant; Health Sciences; Immunobiology; Intramural Research Program; Laboratory Animals; Methods; Modeling; Monitor; Neurosciences; Oklahoma; Papio; Papio anubis; Pertussis; Pharmacologic Substance; Plasma; Primates; Privatization; Production; Research; Research Contracts; Research Personnel; Research Project Grants; Resources; Respiratory syncytial virus; Scientist; Services; Students; System; Tissues; Training; Training and Education; United States National Institutes of Health; Universities; Veterinarians; Virus; Work; Xenograft procedure; age group; animal breeding; animal care; animal resource; cognitive testing; design; genetic analysis; genetic pedigree; genome sequencing; germ free condition; human disease; human model; improved; male; next generation; nonhuman primate; novel; offspring; pathogen; programs; social; tool; training opportunity; virus resource; web site; whole genome

PROJECT SUMMARY: OVERALL COMPONENT This application is a competing renewal of the “Specific Pathogen Free 18 Baboon Research Resource” (SPF18BRR) P40 OD024628. The SPF18BRR was founded with NIH support at the University of Oklahoma Health Sciences Center (OUHSC) in 2002 and was relocated to the Keeling Center in 2017. The SPF18BRR has received continuous NIH support since it was founded. The SPF18BRR is the only national research resource of adventitious virus free olive baboons (Papio anubis) that are available to NIH grantees; intramural research programs of federal agencies, including the FDA, NSF and NIH; and other sponsors of biomedical research (private foundations, pharmaceutical companies, and contract research organizations). Absolutely unique in the entire world, the baboons in the SPF18BRR have an extensive bioexclusion list of 18 pathogens normally found in other wild and captive nonhuman primate colonies. The SPF18BRR has integrated multiple disciplines into a program designed to meet the needs of investigators who utilize its resources. During the proposed period of support, the SPF18BRR will continue to improve the resources it provides to users and will continue to add new information about the biology and research value of virus free baboons to its website. Baboons continue to be important animal model for genetically engineered pig xenotransplantation, are the only NHP model of respiratory syncytial virus and whooping cough, and they remain a very important model of bacterial sepsis. Additionally, baboons are excellent models of human COVID associated pneumonia, and they were instrumental in the development of approved vaccines for SARS CoV-2. Over the next five years, the SPF18BRR will focus on expanding the SPF18 baboon breeding colony to meet current and future biomedical research needs. The aims of the Resource Core Component address our continued commitment to expanding the SPF18 baboon breeding colony, we will increase the genetic diversity of the SPF18 breeding colony, and we will provide SPF18 baboons, facilities, training, and expertise to the scientific community. The Applied Research Component will include projects to develop methods to train and collect data from automated cognitive testing systems in socially living baboons; we will also determine a DNA methylation clock for our baboon colony, and will perform baseline biomarker analysis for a panel of 30 biomarkers for all animals over 3 years old in our colony; and, we will perform whole genome sequencing on 9 future conventional baboon breeders from the Southwest National Primate Center’s olive baboon colony, as well as targeted genomic sequencing on other interesting animals from the SPF18BRR. The overall goals of theSPF18BRR are to provide a national research resource of virus free olive baboons; provide baboon derived biological materials; provide education and training opportunities to scientist, colony managers, and animal caregivers who want to work with baboons; and to provide investigators with facilities and expertise to conduct studies using virus free baboons.

项目概要：总体组成部分 此应用程序是“无特定病原体18狒狒研究资源”的竞争性更新 （SPF18BRR）P40 OD 024628。SPF 18 BRR是在美国国立卫生研究院的支持下在俄克拉荷马州大学建立的 健康科学中心（OUHSC）在2002年，并于2017年搬迁到基林中心。SPF18BRR 自成立以来一直得到NIH的支持。SPF 18 BRR是唯一一款 无外来病毒橄榄狒狒（Papio anubis）的资源，可供NIH赠款;校内 包括FDA、NSF和NIH在内的联邦机构的研究计划;以及生物医学的其他赞助商 研究（私人基金会、制药公司和合同研究组织）。绝对 SPF 18 BRR中的狒狒在全世界都是独一无二的，它有一个包含18种病原体的广泛的生物排斥列表 通常在其他野生和圈养的非人类灵长类动物群体中发现。SPF 18 BRR集成了多种 学科纳入一个计划，旨在满足谁利用其资源的调查人员的需求。期间 在建议的支持期内，SPF 18 BRR将继续改善其向用户提供的资源， 将继续在其网站上增加有关无病毒狒狒的生物学和研究价值的新信息。 狒狒仍然是基因工程猪异种移植的重要动物模型， 只有呼吸道合胞病毒和百日咳的NHP模型，它们仍然是非常重要的模型 细菌性败血症此外，狒狒是人类COVID相关肺炎的极好模型， 他们在开发SARS CoV-2的批准疫苗方面发挥了重要作用。在接下来的五年里， SPF 18 BRR将重点扩大SPF 18狒狒繁殖群，以满足当前和未来的需求 生物医学研究需要。资源核心部分的目标是解决我们持续的 承诺扩大SPF 18狒狒繁殖群体，我们将增加遗传多样性的 SPF 18繁殖群，我们将提供SPF 18狒狒，设施，培训和专业知识的科学 社区应用研究部分将包括开发培训和收集方法的项目 来自社会生活狒狒的自动认知测试系统的数据;我们还将确定一个DNA 我们的狒狒群体的甲基化时钟，并将进行基线生物标志物分析的小组30 生物标志物的所有动物超过3岁，在我们的殖民地;和，我们将进行全基因组测序 来自西南国家灵长类动物中心橄榄狒狒群的9只未来的传统狒狒繁殖者， 以及来自SPF 18 BRR的其他感兴趣动物的靶向基因组测序。总目标 的SPF 18 BRR是提供无病毒橄榄狒狒的国家研究资源;提供 狒狒衍生的生物材料;为科学家提供教育和培训机会， 管理人员和想要与狒狒一起工作的动物护理人员;并为研究人员提供 使用无病毒狒狒进行研究的设施和专业知识。