Sorbents for Toxic-Metal Removal in Pharmaceutical Development and Manufacture

用于药物开发和制造中有毒金属去除的吸附剂

基本信息

  • 批准号:
    8200619
  • 负责人:
  • 金额:
    $ 15万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-09-01 至 2012-09-29
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Sorbents for Toxic-Metal Removal in Pharmaceutical Development and Manufacture SBIR Phase I Application P.I.: Girish Srinivas, TDA Research, Inc. The overall project goal is to minimize toxic impurities in pharmaceuticals that arise during drug synthesis. Toxic contaminants include the metals used as catalysts during drug synthesis and undesired organic side-products produced by metal catalysts remaining in solution between synthetic steps. Sorbents are being developed to lower concentrations of catalytic metals, Pd, Pt, Rh, Ru and Ir to below 500 parts per billion by mass, the recommended maximum for intravenous injection. Homogeneous catalysts using Pt-group metals, and especially Pd, have revolutionized drug development and synthesis. However, many coordination compounds of the Pt-group metals have been found to be extremely toxic, producing effects similar to mercury and lead. This is well established from the known neurotoxicity and cytotoxicity of the anti- cancer agents, cis-platinum, cis-palladium and their analogues, which bind strongly to DNA and block transcription of critical neural enzymes and also bind, for example, to sulfhydryl groups at active sites of enzymes that are critical for energy metabolism in the nervous system. Moreover, homogeneous catalysts used in drug synthesis are often designed with lipophilic ligands, which allow rapid transport through lipid membranes analogous to transport of methyl mercury and tetraethyl lead. Modern drug synthesis may involve three or more catalytic steps. If metal catalysts used in early steps are not removed, they may catalyze formation of toxic organic side- products, not easily separated from drug molecules. Homogeneous catalysts may degrade, forming cluster compounds and nano-suspensions, which, if not removed between synthesis steps, catalyze additional side-reactions. To remove the entire range of toxic-metal particles under 10 nm, which are not easily removed by filtration or by centrifugation, carbon sorbents are being developed. The porous carbons, specifically designed for the pharmaceutical industry, will remove the entire range of toxic metal species, without significantly adsorbing drug product. PUBLIC HEALTH RELEVANCE: Sorbents for Toxic-Metal Removal in Pharmaceutical Development and Manufacture SBIR Phase I Application P.I.: Girish Srinivas, TDA Research, Inc. Public Health Relevance Statement: Many pharmaceuticals prescribed to millions of patients are contaminated with toxic impurities originating from metal catalysts used during drug synthesis. The toxic metals accumulate in the nervous system causing damage similar to that of mercury and lead. Improved purification of medications will reduce many toxic side-effects.
描述(由申请人提供):用于制药开发和制造中有毒金属去除的吸着剂SBIR第一阶段应用P.I.:TDA Research,Inc.的Girish Srinivas。该项目的总体目标是将药物合成过程中出现的有毒杂质降至最低。有毒污染物包括在药物合成过程中用作催化剂的金属,以及在合成步骤之间留在溶液中的金属催化剂产生的不受欢迎的有机副产品。正在开发吸着剂,以将催化金属Pd、铂、Rh、Ru和Ir的浓度降低到万分之500以下,这是推荐的静脉注射最高浓度。使用铂族金属的均相催化剂,特别是钯,已经彻底改变了药物的开发和合成。然而,许多铂族金属的配位化合物被发现具有极高的毒性,产生类似于汞和铅的效果。这是从已知的抗癌药物顺铂、顺铂及其类似物的神经毒性和细胞毒性出发的,它们与DNA强烈结合,阻止关键神经酶的转录,还与例如对神经系统能量代谢至关重要的酶活性部位的巯基结合。此外,用于药物合成的均相催化剂通常设计有亲脂配体,允许快速通过脂膜传输,类似于甲基汞和四乙基铅的传输。现代药物合成可能涉及三个或三个以上的催化步骤。如果不去除早期步骤中使用的金属催化剂,它们可能会催化形成有毒的有机副产物,这些副产物不易从药物分子中分离出来。均相催化剂可能会降解,形成簇状化合物和纳米悬浮液,如果在合成步骤之间不去除它们,就会催化额外的副反应。为了去除10纳米以下的所有有毒金属颗粒,这些颗粒不容易通过过滤或离心法去除,碳吸附剂正在开发中。这种专门为制药行业设计的多孔炭将去除所有有毒金属物种,而不会显著吸附药物产品。 公共卫生相关性:药品开发和制造中用于去除有毒金属的吸着剂SBIR第一阶段应用P.I.:吉里什·斯里尼瓦斯,TDA研究公司。公共卫生相关性声明:开给数百万患者的许多药物都受到有毒杂质的污染,这些杂质来自药物合成过程中使用的金属催化剂。有毒金属聚集在神经系统中,造成类似于汞和铅的损害。改进药物的提纯将减少许多毒副作用。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

GIRISH SRINIVAS其他文献

GIRISH SRINIVAS的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('GIRISH SRINIVAS', 18)}}的其他基金

Advanced Pediatric Airway Trainer for Enhanced Clinical Education in Pediatric Critical Care
高级儿科气道训练器,用于加强儿科重症监护的临床教育
  • 批准号:
    10603760
  • 财政年份:
    2023
  • 资助金额:
    $ 15万
  • 项目类别:
Improved Respirator Carbons for Ammonia Hazards
改进呼吸器碳以应对氨危害
  • 批准号:
    9139745
  • 财政年份:
    2016
  • 资助金额:
    $ 15万
  • 项目类别:
Antimicrobial Coatings to Reduce Hospital Infections
抗菌涂层可减少医院感染
  • 批准号:
    8906076
  • 财政年份:
    2015
  • 资助金额:
    $ 15万
  • 项目类别:
End-of-Service Life Indicator (ESLI)
使用寿命终止指示器 (ESLI)
  • 批准号:
    8715240
  • 财政年份:
    2014
  • 资助金额:
    $ 15万
  • 项目类别:
Sorbents for Toxic-Metal Removal in Pharmaceutical Development and Manufacture
用于药物开发和制造中有毒金属去除的吸附剂
  • 批准号:
    8455581
  • 财政年份:
    2011
  • 资助金额:
    $ 15万
  • 项目类别:
Sorbents for Toxic-Metal Removal in Pharmaceutical Development and Manufacture
用于药物开发和制造中有毒金属去除的吸附剂
  • 批准号:
    8544399
  • 财政年份:
    2011
  • 资助金额:
    $ 15万
  • 项目类别:
System for Decontaminating Well Water for Drinking
饮用井水净化系统
  • 批准号:
    7910098
  • 财政年份:
    2010
  • 资助金额:
    $ 15万
  • 项目类别:
End of Life Service Indicator
寿命终止服务指示器
  • 批准号:
    7747597
  • 财政年份:
    2009
  • 资助金额:
    $ 15万
  • 项目类别:
Firefighter Mask
消防员面具
  • 批准号:
    7482011
  • 财政年份:
    2008
  • 资助金额:
    $ 15万
  • 项目类别:
Cooling Suit for First Responders
急救人员的冷却服
  • 批准号:
    7909797
  • 财政年份:
    2007
  • 资助金额:
    $ 15万
  • 项目类别:

相似国自然基金

Glymphatic系统功能损害影响toxic milk小鼠脑铜清除的机制研究
  • 批准号:
    81701122
  • 批准年份:
    2017
  • 资助金额:
    20.0 万元
  • 项目类别:
    青年科学基金项目

相似海外基金

Technology to reduce transfer, accumulation, and toxic effects on organisms and humans without reducing heavy metal concentrations in contaminated soil
减少转移、积累以及对生物体和人类的毒性影响而不降低受污染土壤中重金属浓度的技术
  • 批准号:
    23H03545
  • 财政年份:
    2023
  • 资助金额:
    $ 15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Contraceptive DMPA-induced bone loss: A novel source of toxic metal lead exposure in young women
避孕药 DMPA 引起的骨质流失:年轻女性有毒金属铅暴露的新来源
  • 批准号:
    10714991
  • 财政年份:
    2023
  • 资助金额:
    $ 15万
  • 项目类别:
Impact of Toxic Metal Exposures in Novel Genetic Mouse Models of Late-Onset Alzheimer's Disease
有毒金属暴露对迟发性阿尔茨海默病的新型基因小鼠模型的影响
  • 批准号:
    10901030
  • 财政年份:
    2023
  • 资助金额:
    $ 15万
  • 项目类别:
Long range toxic metal pollution in Australia and the Southern Ocean
澳大利亚和南大洋的远距离有毒金属污染
  • 批准号:
    DP220100828
  • 财政年份:
    2022
  • 资助金额:
    $ 15万
  • 项目类别:
    Discovery Projects
Understanding of Stabilization Mechanism of Toxic Metal by Geopolymer Solidification and Its Practical Application
地质聚合物固化稳定有毒金属机理的认识及其实际应用
  • 批准号:
    22H03772
  • 财政年份:
    2022
  • 资助金额:
    $ 15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Neurological effects of toxic metal exposure in model rodents collected in zones of industrial agriculture on the U.S.-Mexico border
美国-墨西哥边境工业化农业区收集的模型啮齿动物暴露有毒金属对神经系统的影响
  • 批准号:
    10312899
  • 财政年份:
    2022
  • 资助金额:
    $ 15万
  • 项目类别:
Neurological effects of toxic metal exposure in model rodents collected in zones of industrial agriculture on the U.S.-Mexico border
美国-墨西哥边境工业化农业区收集的模型啮齿动物暴露有毒金属对神经系统的影响
  • 批准号:
    10558449
  • 财政年份:
    2022
  • 资助金额:
    $ 15万
  • 项目类别:
The role of toxic and essential metal mixtures, and co-exposures to social stressors, in cognitive aging, mild cognitive impairment, and novel epigenetic age biomarkers: The Baltimore Memory Study
有毒和必需金属混合物以及共同暴露于社会压力源在认知衰老、轻度认知障碍和新型表观遗传年龄生物标志物中的作用:巴尔的摩记忆研究
  • 批准号:
    10428366
  • 财政年份:
    2021
  • 资助金额:
    $ 15万
  • 项目类别:
An investigation into Metal-Organic Frameworks for toxic gas adsorption and separation
金属有机框架用于有毒气体吸附和分离的研究
  • 批准号:
    NE/V021389/1
  • 财政年份:
    2021
  • 资助金额:
    $ 15万
  • 项目类别:
    Research Grant
Socioenvironmental Causes of Elevated Toxic Metal Levels and Epigenetic Aging
有毒金属水平升高和表观遗传衰老的社会环境原因
  • 批准号:
    10615032
  • 财政年份:
    2021
  • 资助金额:
    $ 15万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了