Core--NeuroAIDS

核心--NeuroAIDS

• 批准号: 6228544
• 负责人: IGOR GRANT
• 金额: $ 20.82万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6228544
• 关键词: AIDS /HIV neuropathy; biomedical facility; data management; medical outreach /case finding; methamphetamine; patient /disease registry; statistics /biometry

The primary objectives of the Core are 1) to assure the integrated, coherent, and effective implementation of the Program and 2) to provide basic neuromedical, virological, and neuropsychiatric characterization of Program participants. To perform its duties in an efficient and accountable manner, the Core has been organized into five interacting units which are complemented by resources available through the HIV Neurobehavioral Research Center (HNRC). The Executive Unit is responsible for coordinating the activities of the Program on a day-to-day basis and has specific responsibility for the monitoring of protocol implementation and maintenance of effective communications internally between investigators and staff and externally between the Program and the University, the community, and the Agency. The Participant Accrual and Retention (PAR) Unit is responsible for identification, recruitment, consenting, and follow-up of participants. The PAR Unit also coordinates and monitors human subjects affairs, and reports to the Program Director on participant issues. The Assessment Unit is responsible for neuromedical evaluations and the collection and analysis of blood and CSF specimens from all participants. This Unit will also assess each participant s psychiatric and substance use history. In addition, Assessment Unit personnel will provide evaluation results to participants and, with consent, to service providers. The Data Management Unit provides the conceptual framework, procedures, software, hardware, and quality control mechanisms required to manage a complex and interactive set of data. The Statistics Unit consults with Projects on design and data analysis plans, statistical modeling, the reduction of data to composite variables, advanced analyses, including longitudinal, logistic, and survival analyses (with particular emphasis on cross-project analyses), and explores new statistical methods of analysis while addressing Program-related research questions. Beyond the above described five units, the Core also coordinates the activities of critical internal and external working groups within the Program. The internal groups include the Council of Investigators (sets policy and reviews scientific progress on a regular basis); the Director s Staff (assists in the practical management of the Program); the Data, Statistics, and Publications Committee (reviews analyses and manuscripts); and the Confidentiality Committee, (monitors human subjects protection). The external groups include the Participant s Advisory Board (provides feedback from participants to the Director); the Community Advisory Board (provides advice and feedback on the functioning of the Program in various communities); and the Scientific Advisory Board (provides periodic independent review of our progress).

核心的主要目标是：1）确保计划的综合、一致和有效实施; 2）提供计划参与者的基本神经医学、病毒学和神经精神病学特征。 为了以有效和负责的方式履行其职责，核心小组被组织成五个相互作用的单位，由艾滋病毒神经行为研究中心提供的资源予以补充。执行部门负责协调该计划的日常活动，并具体负责监测方案的执行情况，并维护研究人员和工作人员之间的内部有效沟通以及该计划与大学、社区和机构之间的外部有效沟通。 参与者应计和保留股负责参与者的确定、征聘、同意和跟踪。 PAR单位还协调和监测人类受试者事务，并向项目主任报告参与者问题。 评估单位负责神经医学评价以及所有参与者的血液和CSF样本的收集和分析。该股还将评估每个参与者的精神病和物质使用史。此外，评估股工作人员将向参与者提供评估结果，并在征得同意后向服务提供者提供。数据管理股提供管理一套复杂和互动的数据所需的概念框架、程序、软件、硬件和质量控制机制。 统计单位与设计和数据分析计划，统计建模，减少数据的复合变量，先进的分析，包括纵向，逻辑和生存分析（特别强调跨项目分析）的项目咨询，并探讨新的统计分析方法，同时解决程序相关的研究问题。除上述五个单位外，核心还协调方案内重要的内部和外部工作组的活动。 内部小组包括研究者理事会（制定政策并定期审查科学进展）;主任的工作人员（协助项目的实际管理）;数据、统计和出版物委员会（审查分析和手稿）;保密委员会（监测人类受试者保护）。 外部团体包括参与者咨询委员会（向主任提供参与者的反馈）;社区咨询委员会（提供有关该计划在各个社区的运作的建议和反馈）;和科学咨询委员会（定期独立审查我们的进展）。