Core--NeuroAIDS

核心的主要目标是：1)确保项目的整合、连贯和有效实施；2)为项目参与者提供基本的神经医学、病毒学和神经精神特征。为了以有效和负责任的方式履行其职责，核心已被组织成五个相互作用的单位，并由艾滋病毒神经行为研究中心（HNRC）提供的资源加以补充。执行单位负责协调方案的日常活动，并具体负责监督方案的执行情况，并在内部调查员和工作人员之间以及在外部方案与大学、社区和机构之间保持有效的沟通。参与者累积和保留（PAR）单位负责确定、招募、同意和跟踪参与者。PAR股还协调和监测人类受试者事务，并向项目主任报告参与者问题。评估股负责神经医学评估以及收集和分析所有参与者的血液和脑脊液标本。该小组还将评估每位参与者的精神病史和药物使用史。此外，评价股人员将向参与者提供评价结果，并在征得服务提供者同意的情况下向其提供评价结果。数据管理股提供管理一组复杂和相互作用的数据所需的概念框架、程序、软件、硬件和质量控制机制。统计组在设计和数据分析计划、统计建模、将数据简化为复合变量、高级分析（包括纵向分析、逻辑分析和生存分析）（特别强调跨项目分析）等方面为项目提供咨询，并在解决项目相关研究问题的同时探索新的统计分析方法。除了上述五个单位之外，核心还协调方案内关键的内部和外部工作组的活动。内部小组包括调查委员会（制定政策并定期审查科学进展）；主任工作人员（协助项目的实际管理）；数据、统计和出版物委员会（审查、分析和手稿）；保密委员会（监测人类受试者的保护情况）。外部团体包括参加者谘询委员会（向署长提供参加者的意见）；社区咨询委员会（就项目在各个社区的运作提供建议和反馈）；科学顾问委员会（定期对我们的进展进行独立审查）。

The primary objectives of the Core are 1) to assure the integrated, coherent, and effective implementation of the Program and 2) to provide basic neuromedical, virological, and neuropsychiatric characterization of Program participants. To perform its duties in an efficient and accountable manner, the Core has been organized into five interacting units which are complemented by resources available through the HIV Neurobehavioral Research Center (HNRC). The Executive Unit is responsible for coordinating the activities of the Program on a day-to-day basis and has specific responsibility for the monitoring of protocol implementation and maintenance of effective communications internally between investigators and staff and externally between the Program and the University, the community, and the Agency. The Participant Accrual and Retention (PAR) Unit is responsible for identification, recruitment, consenting, and follow-up of participants. The PAR Unit also coordinates and monitors human subjects affairs, and reports to the Program Director on participant issues. The Assessment Unit is responsible for neuromedical evaluations and the collection and analysis of blood and CSF specimens from all participants. This Unit will also assess each participant s psychiatric and substance use history. In addition, Assessment Unit personnel will provide evaluation results to participants and, with consent, to service providers. The Data Management Unit provides the conceptual framework, procedures, software, hardware, and quality control mechanisms required to manage a complex and interactive set of data. The Statistics Unit consults with Projects on design and data analysis plans, statistical modeling, the reduction of data to composite variables, advanced analyses, including longitudinal, logistic, and survival analyses (with particular emphasis on cross-project analyses), and explores new statistical methods of analysis while addressing Program-related research questions. Beyond the above described five units, the Core also coordinates the activities of critical internal and external working groups within the Program. The internal groups include the Council of Investigators (sets policy and reviews scientific progress on a regular basis); the Director s Staff (assists in the practical management of the Program); the Data, Statistics, and Publications Committee (reviews analyses and manuscripts); and the Confidentiality Committee, (monitors human subjects protection). The external groups include the Participant s Advisory Board (provides feedback from participants to the Director); the Community Advisory Board (provides advice and feedback on the functioning of the Program in various communities); and the Scientific Advisory Board (provides periodic independent review of our progress).