Core--NeuroAIDS

CORE的主要目标是：1)确保计划的整体、连贯和有效实施；2)为计划参与者提供基本的神经医学、病毒学和神经精神病学特征。为了以高效和负责的方式履行其职责，核心被组织成五个相互作用的单位，并得到艾滋病毒神经行为研究中心提供的资源的补充。执行股负责协调方案的日常活动，并具体负责监测方案的执行情况，以及在内部和外部监督方案与大学、社区和机构之间的有效沟通。参与人应计和留用股(PAR)负责确定、招募、同意和跟踪参与人。PAR股还协调和监测人类受试者事务，并就参与者问题向方案主任报告。评估股负责神经医学评估以及收集和分析所有参与者的血液和脑脊液样本。该股还将评估每位参与者S的精神和药物使用史。此外，评估股工作人员将向参与者提供评价结果，并在征得同意后向服务提供者提供评价结果。数据管理股提供管理一组复杂和交互数据所需的概念框架、程序、软件、硬件和质量控制机制。统计股就设计和数据分析计划、统计建模、将数据简化为复合变量、包括纵向分析、逻辑分析和生存分析(特别强调跨项目分析)等高级分析与项目进行协商，并探讨新的统计分析方法，同时处理与方案有关的研究问题。除上述五个单位外，核心还协调方案内重要的内部和外部工作组的活动。内部小组包括调查委员会(制定政策并定期审查科学进展)；S主任工作人员(协助项目的实际管理)；数据、统计和出版委员会(审查分析和手稿)；以及保密委员会(监督人类受试者保护)。外部小组包括参与者S咨询委员会(向主任提供参与者的反馈)、社区咨询委员会(就计划在各个社区的运作提供建议和反馈)以及科学咨询委员会(对我们的进展进行定期的独立审查)。

The primary objectives of the Core are 1) to assure the integrated, coherent, and effective implementation of the Program and 2) to provide basic neuromedical, virological, and neuropsychiatric characterization of Program participants. To perform its duties in an efficient and accountable manner, the Core has been organized into five interacting units which are complemented by resources available through the HIV Neurobehavioral Research Center (HNRC). The Executive Unit is responsible for coordinating the activities of the Program on a day-to-day basis and has specific responsibility for the monitoring of protocol implementation and maintenance of effective communications internally between investigators and staff and externally between the Program and the University, the community, and the Agency. The Participant Accrual and Retention (PAR) Unit is responsible for identification, recruitment, consenting, and follow-up of participants. The PAR Unit also coordinates and monitors human subjects affairs, and reports to the Program Director on participant issues. The Assessment Unit is responsible for neuromedical evaluations and the collection and analysis of blood and CSF specimens from all participants. This Unit will also assess each participant s psychiatric and substance use history. In addition, Assessment Unit personnel will provide evaluation results to participants and, with consent, to service providers. The Data Management Unit provides the conceptual framework, procedures, software, hardware, and quality control mechanisms required to manage a complex and interactive set of data. The Statistics Unit consults with Projects on design and data analysis plans, statistical modeling, the reduction of data to composite variables, advanced analyses, including longitudinal, logistic, and survival analyses (with particular emphasis on cross-project analyses), and explores new statistical methods of analysis while addressing Program-related research questions. Beyond the above described five units, the Core also coordinates the activities of critical internal and external working groups within the Program. The internal groups include the Council of Investigators (sets policy and reviews scientific progress on a regular basis); the Director s Staff (assists in the practical management of the Program); the Data, Statistics, and Publications Committee (reviews analyses and manuscripts); and the Confidentiality Committee, (monitors human subjects protection). The external groups include the Participant s Advisory Board (provides feedback from participants to the Director); the Community Advisory Board (provides advice and feedback on the functioning of the Program in various communities); and the Scientific Advisory Board (provides periodic independent review of our progress).