Comprehensive NeuroAIDS Core Center

这份修订后的申请寻求支持在坦普尔大学医学院建立一个综合神经艾滋病核心中心(CNACC)，以便为参与艾滋病毒-1/艾滋病研究的基础科学家和临床医生提供急需的基础设施，以及神经学、神经退行性和神经行为障碍。CNACC的中心主题是基于我们的假设构建的，即在分子、细胞和实验动物模型水平上了解HIV-1/CNS相互作用的机制，以及双向交流实验室结果和临床观察以验证基础科学发现，是开发有效、安全和可靠的方法来早期诊断和治疗艾滋病相关神经功能障碍的先决条件。CNACC将为一大批神经艾滋病研究人员提供前所未有的基础设施，他们计划在细胞培养、小动物模型以及临床环境中使用多学科方法来追求他们的目标，以便在细胞和分子水平上评估基因表达和生物标记物识别。此外，通过发展核心，CNACC将为初级和临床研究人员的培训和指导提供独特的机会，并吸引和发展神经艾滋病领域的内科科学家。通过CNACC，我们将为新招聘的独立调查人员的新的和创新的试点项目提供启动资金，并将支持更多老牌神经艾滋病调查人员的可行性研究。通过该中心提供的资金将创建一个独特的基础设施，用于增强和扩大正在进行的艾滋病毒-1调查的有效性，并促进坦普尔和大费城地区参与基础科学和临床艾滋病研究的其他医疗机构的神经艾滋病转化研究。凭借其全面的结构组织，包括从分子生物学到实验动物，再到由来自不同学科的熟练和高能力研究人员指导的临床领域的广泛核心，CNACC将支持各种领域的研究，如病毒学、基础和行为神经科学以及临床科学，所有这些领域都旨在发现更好的艾滋病/中枢神经系统疾病的诊断和有效的治疗药物。

This revised application seeks support to establish a Comprehensive NeuroAIDS Core Center (CNACC) at the Temple University School of Medicine in order to bring highly needed infrastructure for basic scientists and clinicians involved in HIV-1/AIDS research and neurological, neurodegenerative, and neurobehavioral disorders. The central theme of CNACC is structured based on our hypothesis that understanding the mechanisms of HIV-1/CNS interactions at the molecular, cellular, and experimental animal model levels and bidirectional communication of laboratory findings and clinical observations to validate basic science discoveries are prerequisites for the development of effective, safe, and reliable approaches for early diagnostics and therapeutics for AIDS-associated neurological dysfunctions. The CNACC will provide unprecedented infrastructure to a large group of neuroAIDS investigators who plan to pursue their objectives using multidisciplinary approaches in cell culture, small animal models, and in the clinical setting for assessing gene expression and biomarker identification at the cellular and molecular levels. Further, through the Developmental Core, the CNACC will provide a unique opportunity for training and mentoring of junior and clinical investigators and attract and develop physician scientists in the field of neuroAIDS. Through CNACC, we will provide start-up funds for new and innovative pilot projects of newly recruited, independent investigators and will support feasibility studies for more established neuroAIDS investigators. The funding through this center will create a unique infrastructure that will serve to enhance and extend the effectiveness of ongoing HIV-1 investigations and promote translational research in neuroAIDS at Temple and other medical institutions in the greater Philadelphia area that are involved in basic science and clinical AIDS research. With its comprehensive structural organization encompassing broadly based cores ranging from molecular biology to experimental animals to the clinical arena directed by skilled and highly competent investigators from various disciplines, CNACC will support research in a variety of areas such as virology, basic and behavioral neuroscience, and clinical science, all of which are aimed toward the discovery of better diagnostics and effective therapeutic agents toward AIDS/CNS disorders.